Results 201 to 210 of about 55,128 (251)
Some of the next articles are maybe not open access.
The American Journal of Medicine, 1984
The pharmacokinetics of ibuprofen (Motrin) are best described by a two-compartment open model. Ibuprofen pharmacokinetics are only minimally influenced by advanced age, the presence of alcoholic liver disease, or rheumatoid arthritis. Levels of ibuprofen in breast milk are negligible.
K S, Albert, C M, Gernaat
openaire +2 more sources
The pharmacokinetics of ibuprofen (Motrin) are best described by a two-compartment open model. Ibuprofen pharmacokinetics are only minimally influenced by advanced age, the presence of alcoholic liver disease, or rheumatoid arthritis. Levels of ibuprofen in breast milk are negligible.
K S, Albert, C M, Gernaat
openaire +2 more sources
Southern Medical Journal, 1977
In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo. Each treatment was given for four weeks. Considering relief of pain, ability to function, and general well-being, the patients preferred drug to placebo, usually by a ...
J E, Giansiracusa +5 more
openaire +2 more sources
In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo. Each treatment was given for four weeks. Considering relief of pain, ability to function, and general well-being, the patients preferred drug to placebo, usually by a ...
J E, Giansiracusa +5 more
openaire +2 more sources
Evidence for Self-Medication, 2021
Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastrointestinal tract. Since the degree of gastric filling can have a significant influence on absorption, two studies investigated the pharmacokinetics of ...
openaire +1 more source
Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastrointestinal tract. Since the degree of gastric filling can have a significant influence on absorption, two studies investigated the pharmacokinetics of ...
openaire +1 more source
Annals of Internal Medicine, 1979
Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anti-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of
openaire +2 more sources
Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anti-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of
openaire +2 more sources
Solubility of ( ± )-Ibuprofen and S ( + )-Ibuprofen in the Presence of Cosolvents and Cyclodextrins
Pharmaceutical Development and Technology, 2005Aqueous solubility is an important parameter for the development of liquid formulations and in the determination of bioavailability of oral dosage forms. Ibuprofen (IB), a nonsteroidal anti-inflammatory drug, is a chiral molecule and is currently used clinically as a racemate (racIB).
Jayanti, Nerurkar +3 more
openaire +2 more sources
Pediatrics, 1991
To the Editor.— I am writing to voice concern about the use of ibuprofen for simple antipyresis in infants and young children. Although there have been enough data about the new liquid preparation to convince the Federal Drug Administration to release it, it must be recognized that the total number of infants and young children reported ...
openaire +2 more sources
To the Editor.— I am writing to voice concern about the use of ibuprofen for simple antipyresis in infants and young children. Although there have been enough data about the new liquid preparation to convince the Federal Drug Administration to release it, it must be recognized that the total number of infants and young children reported ...
openaire +2 more sources
The American Journal of Medicine, 1984
Primary dysmenorrhea and secondary dysmenorrhea induced by an intrauterine device are associated with increased production and release of endometrial prostaglandins. The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen.
openaire +2 more sources
Primary dysmenorrhea and secondary dysmenorrhea induced by an intrauterine device are associated with increased production and release of endometrial prostaglandins. The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen.
openaire +2 more sources
Annals of Emergency Medicine, 1991
A prospective study of 63 ibuprofen overdose cases in adults (14 years or older) reported to the Rocky Mountain Poison and Drug Center between March 1987 and February 1988 was done to determine the incidence of renal injury and utility of timed plasma levels. No serious toxicity was noted. No CNS or other significant toxicity was seen with ingestion of
A H, Hall +4 more
openaire +2 more sources
A prospective study of 63 ibuprofen overdose cases in adults (14 years or older) reported to the Rocky Mountain Poison and Drug Center between March 1987 and February 1988 was done to determine the incidence of renal injury and utility of timed plasma levels. No serious toxicity was noted. No CNS or other significant toxicity was seen with ingestion of
A H, Hall +4 more
openaire +2 more sources
Comparative Pharmacology of S(+)-Ibuprofen and (RS)-Ibuprofen
Clinical Rheumatology, 2001Racemic ibuprofen, which contains equal quantities of R(-)-ibuprofen and S(+)-ibuprofen, has been used as an anti-inflammatory and analgesic agent for over 30 years. Although the S(+)-enantiomer is capable of inhibiting cyclooxygenase (COX) at clinically relevant concentrations, R(-)-ibuprofen is not a COX inhibitor.
openaire +2 more sources
2000
Abstract Ibuprofen is a well-tolerated, nonsteroidal anti-inflammatory agent; it is one of a group of propionic acid-derived, aspirin-like agents available over-the-counter in North America. The anti-inflammatory properties of the propionic acid derivatives stem from inhibition of prostaglandin biosynthesis.
openaire +1 more source
Abstract Ibuprofen is a well-tolerated, nonsteroidal anti-inflammatory agent; it is one of a group of propionic acid-derived, aspirin-like agents available over-the-counter in North America. The anti-inflammatory properties of the propionic acid derivatives stem from inhibition of prostaglandin biosynthesis.
openaire +1 more source