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Determination of Solubility Parameters of Ibuprofen and Ibuprofen Lysinate [PDF]
Molecules, 2015 In recent years there has been a growing interest in formulating solid dispersions, which purposes mainly include solubility enhancement, sustained drug release and taste masking. The most notable problem by these dispersions is drug-carrier (in)solubility.
Aleksandra Dumičić +2 more
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Xenobiotica, 1973
1. After oral administration ibuprofen appeared mainly in unchanged form in the plasma of rats, dogs, baboons and men.
R F, Mills +4 more
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1. After oral administration ibuprofen appeared mainly in unchanged form in the plasma of rats, dogs, baboons and men.
R F, Mills +4 more
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The American Journal of Medicine, 1984
The pharmacokinetics of ibuprofen (Motrin) are best described by a two-compartment open model. Ibuprofen pharmacokinetics are only minimally influenced by advanced age, the presence of alcoholic liver disease, or rheumatoid arthritis. Levels of ibuprofen in breast milk are negligible.
K S, Albert, C M, Gernaat
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The pharmacokinetics of ibuprofen (Motrin) are best described by a two-compartment open model. Ibuprofen pharmacokinetics are only minimally influenced by advanced age, the presence of alcoholic liver disease, or rheumatoid arthritis. Levels of ibuprofen in breast milk are negligible.
K S, Albert, C M, Gernaat
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Southern Medical Journal, 1977
In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo. Each treatment was given for four weeks. Considering relief of pain, ability to function, and general well-being, the patients preferred drug to placebo, usually by a ...
J E, Giansiracusa +5 more
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In a double-blind, multiclinic study, 437 patients with osteoarthritis were treated sequentially with ibuprofen, 1,800 mg/day, and placebo, or with aspirin, 3,600 mg/day, and placebo. Each treatment was given for four weeks. Considering relief of pain, ability to function, and general well-being, the patients preferred drug to placebo, usually by a ...
J E, Giansiracusa +5 more
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Annals of Internal Medicine, 1979
Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anti-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of
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Ibuprofen was introduced in England in 1967 and in the United States in 1974 as an anti-inflammatory drug in humans. It has weak but definite anti-inflammatory properties similar to those of aspirin, milligram for milligram, but with considerably less adverse effect on the stomach. Ibuprofen is chemically related to fenoprofen and naproxen, but lack of
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Evidence for Self-Medication, 2021
Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastrointestinal tract. Since the degree of gastric filling can have a significant influence on absorption, two studies investigated the pharmacokinetics of ...
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Analgesics containing readily soluble ibuprofen (e.g. as the lysinate) were developed with the aim of ensuring a more rapid relief of pain than ibuprofen acid through faster absorption in the gastrointestinal tract. Since the degree of gastric filling can have a significant influence on absorption, two studies investigated the pharmacokinetics of ...
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Solubility of ( ± )-Ibuprofen and S ( + )-Ibuprofen in the Presence of Cosolvents and Cyclodextrins
Pharmaceutical Development and Technology, 2005Aqueous solubility is an important parameter for the development of liquid formulations and in the determination of bioavailability of oral dosage forms. Ibuprofen (IB), a nonsteroidal anti-inflammatory drug, is a chiral molecule and is currently used clinically as a racemate (racIB).
Jayanti, Nerurkar +3 more
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Pediatrics, 1991
To the Editor.— I am writing to voice concern about the use of ibuprofen for simple antipyresis in infants and young children. Although there have been enough data about the new liquid preparation to convince the Federal Drug Administration to release it, it must be recognized that the total number of infants and young children reported ...
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To the Editor.— I am writing to voice concern about the use of ibuprofen for simple antipyresis in infants and young children. Although there have been enough data about the new liquid preparation to convince the Federal Drug Administration to release it, it must be recognized that the total number of infants and young children reported ...
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The American Journal of Medicine, 1984
Primary dysmenorrhea and secondary dysmenorrhea induced by an intrauterine device are associated with increased production and release of endometrial prostaglandins. The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen.
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Primary dysmenorrhea and secondary dysmenorrhea induced by an intrauterine device are associated with increased production and release of endometrial prostaglandins. The condition may be treated by oral contraceptives, which reduce overall menstrual fluid volume, or by a prostaglandin synthetase inhibitor, such as ibuprofen.
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