Results 201 to 210 of about 288,159 (307)

State-specific inhibition of NMDA receptors by memantine provides insight into NMDAR channel blocker tolerability. [PDF]

Sci Adv
Phillips MB, Povysheva NV, Neureiter EG, Nigam A, Harnett-Scott KA, Hell JW, Aizenman E, Johnson JW.   +7 more
europepmc   +1 more source

Spatiotemporal Targeting Randle Cycle and Immune Checkpoint for Potent Antitumor Therapy

Advanced Science, EarlyView.
A glucose oxidase‐based nanogel (GOX‐NG) system using catechol‐functionalized alginate, exhibits enhanced tumor penetration, prolonged retention, and sustained glucose depletion in the tumor microenvironment. When combined with a fatty acid oxidation inhibitor, it implements dual metabolic suppression, thereby enhancing ROS‐induced immunogenic cell ...
Yuan Gao, Zijian Gong, Yixuan Fu, Jianan Zheng, Xiao Sang, Binglin Chen, Qinzhi Su, Weiping Gao, Fei Duan, Jinqi Wei, Xuliang Deng, Xinyu Liu   +11 more
wiley   +1 more source

Red Macroalgae as Sources of Antioxidant and Multifunctional Ingredients for Functional Foods: A Biorefinery Approach. [PDF]

Mar Drugs
Nunes N, Nunes E, Odenthal K, Carvalho MÂAP.   +3 more
europepmc   +1 more source

UJI EFEKTIVITAS ANTIOKSIDANT (IC50) DAN TOKSISITAS AKUT (LD50) FRAKSI ETANOL DAUN NANGKA (Artocarpus Heterophyllus Lam.)

, 2020
Recta Olivia Umboro, Dedent Eka Bimmaharyanto S, Ni Komang Wijiani Yanti   +2 more
openalex   +2 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Temporal Dynamics of Phytochemicals in Selected Medicinal Plants Across Gandaki Province, Nepal. [PDF]

Food Sci Nutr
Paudel D, Koirala S, Bhandari DR, Adhikari A, Poudel BR, Pokhrel MR.   +5 more
europepmc   +1 more source

Optimizing drug sensitivity assays in patient-derived tumor organoids: a comparison of IC50 estimation methods and experimental parameters [PDF]

Yidan Chen, Jian Zhang, Bin Zhang, Hong Kai Lee, Suyao Xie, Weiliang Shen, Xueqin Chen, Ming You, Chongyang Shen, Bing Xia, Huayang Xing   +10 more
openalex   +1 more source

CauFinder: Steering Cell‐State and Phenotype Transitions by Causal Disentanglement Learning

Advanced Science, EarlyView.
CauFinder combines causal disentanglement modeling and network control to prioritize causal drivers of cell‐state transitions from observational transcriptomic data. The framework separates transition‐relevant signals from spurious associations, nominates intervention targets across biological and disease contexts, and identifies DAAM1 as an actionable
Chengming Zhang, Zexi Chen, Yuanxiang Miao, Zuolin Shen, Deyu Cai, Shijie Tang, Yun Xue, Weifeng Guo, Hongbin Ji, Jian Liu, Kazuyuki Aihara, Luonan Chen   +11 more
wiley   +1 more source

Benzimidazole derivatives as dual EGFR and BRAF^V600E inhibitors with pro-apoptotic antiproliferative potential. [PDF]

RSC Adv
Al-Wahaibi LH, Samir M, Bräse S, Youssif BGM, Morcoss MM.   +4 more
europepmc   +1 more source

Preparation, Component Identification, and Antioxidant Activity of Anthocyanins From Punica granatum “Tunisia”

AgriFood: Journal of Agricultural Products for Food, EarlyView.
The preparation for Tunisian pomegranate anthocyanin extract. The molecular mechanisms underlying the antioxidant effects of these compounds were investigated using network pharmacology and molecular docking. Antioxidant activity was evaluated through DPPH, ABTS, and FRAP assays, whereas the effects on oxidative stress and inflammation were examined in
Jing Zhang, Xu‐han Yang, Meng‐qi Zhang, Xu Guo, Ning‐yang Li, Fang‐yu Long, Chao Liu   +6 more
wiley   +1 more source