Results 221 to 230 of about 288,159 (307)

MIC and IC50 for the tested microbial species using the formulation

MIC and IC50 for the tested microbial species using the ...
openaire   +1 more source

596 IC50 determination for receptor-targeted compounds and downstream signaling

European Journal of Cancer Supplements, 2004
H. Salimi-Moosavi, X. Jin, Y. Badal, S. Pidaparthi, P.-Y. Chan-Hui, S. Singh   +5 more
openaire   +1 more source

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

, 2016
Yifeng He, Qiujing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang, Wen Di   +7 more
openalex   +2 more sources

Mesoporous Silica Nanoparticles With Customized Drug Ratio/Loading for Effective Treatment of Gemcitabine‐Resistant Pancreatic Tumors

Advanced NanoBiomed Research, EarlyView.
Redox responsive mesoporous silica nanoparticles (MSNs) were engineered to deliver gemcitabine (Gem) and cisplatin (cisPt) at defined ratios to overcome chemoresistance in pancreatic ductal adenocarcinoma (PDAC). Optimized Gem MSNs and Gem cisPt MSNs enhanced cytotoxicity in murine and human Gem resistant models, with select formulations inducing ...
Tamanna Binte Huq, Sudip Kumar Dam, Doaha Awad, Punnya Anil Kumar Jeeja, Farzana Ferdous, Juan L. Vivero‐Escoto   +5 more
wiley   +1 more source

A Lipid‐Conjugation Strategy for Intracellular Reactive Oxygen Species Control in Hepatic Cells

Angewandte Chemie, EarlyView.
A lipid conjugation strategy anchors a manganese Salen complex within phospholipid membranes, yielding stable, catalytically active liposomes. These lipid–metal assemblies efficiently degrade reactive oxygen species (ROS) and enable intracellular redox control in steatotic HepaRG cells, offering a precise route to biomimetic antioxidant design ...
Olav Vestrheim, Huichao Zhao, Anders Bodholt Nielsen, Nino Wili, Niels Chr. Nielsen, Joseph A. Lyons, Rajeshwar Prosad Mookerjee, Brigitte Städler   +7 more
wiley   +2 more sources

Targeting <i>Leishmania</i> Fe-SOD and Glucose Metabolism with Tripodal and Pyridinacyclophane Polyamines as a Chemotherapeutic Strategy. [PDF]

Metabolites
Martín-Montes Á, Delgado-Pinar E, Bonastre I, Clares MP, Verdejo B, Martínez-Camarena Á, Ballesteros-Garrido R, Martín-Escolano R, Rosales-Lombardo MJ, García-España E, Marín C.   +10 more
europepmc   +1 more source

Mitochondria‐Targeting Moieties Based on N‐Tethered Pyridinium Cations

Angewandte Chemie, EarlyView.
Pyridinium cations were benchmarked as mitochondria‐targeting moieties in a panel of N‐tethered fluorescent‐, bioactive‐, and inert‐cargo conjugates. 3,5‐Diphenylpyridinium (DPPy+) is a competent triphenylphosphonium (TPP+) surrogate, combining high mitochondria‐targeting efficiency with lower intrinsic effects on mitochondrial function.
Ivan Džajić, Natalija Trunkelj, Jernej Repas, Maša Kandušer, Lara Smrdel, Stane Pajk, Lovro Žiberna, Irena Mlinarič‐Raščan, Bostjan Markelc, Tim Bozic, Masa Omerzel, Tanja Jesenko, Maja Cemazar, Katja Kološa, Bojana Žegura, Miha Virant, Matic Lozinšek, Hai M. Nguyen, Joshua A. Nasburg, Heike Wulff, Maxime Gueguinou, Valerije Vrček, Veronica Carpanese, Ildiko Szabo, Luis A. Pardo, Tihomir Tomašič, Lucija Peterlin Mašič, Andrej Emanuel Cotman   +27 more
wiley   +2 more sources

Targeting Selectivity: Improving Golgi α-Mannosidase II (GMII) Inhibitors Through In Silico Studies. [PDF]

Biomolecules
Ledesma NG, Nieto CT, Manchado A, Castro MÁ, Diez D.   +4 more
europepmc   +1 more source

ROBUST AND RIGOROUS IC50 DETERMINATION FOR PRECLINICAL DRUG DISCOVERY

Hematology, Transfusion and Cell Therapy
Letícia Fernanda Alves, Gilberto Carlos Franchi Júnior, Alessandra Rodrigues Cardoso Padovam, Leticia Pires de Oliveira, Pedro Paulo Corbi, Carmen Silvia Passos Lima, Diego Samuel Rodrigues   +6 more
openaire   +1 more source