Results 221 to 230 of about 504,672 (298)

Early effects of ionizing radiation on molecular modifications and hallmarks of Immunogenic cell death in mouse tumor cells. [PDF]

BMC Cancer
Kesar U, Markelc B, Cemazar M, Sersa G, Jesenko T, Strojan P.   +5 more
europepmc   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source

A Miniaturized Two-Electrode Detection System for Convenient and Rapid Ferricyanide-Mediated Chemical Toxicity Screening. [PDF]

Anal Chem
Buppasirakul K, Suginta W, Schulte A.
europepmc   +1 more source

Using metrics other than IC50 to assess cancer drug response [PDF]

Science-Business eXchange, 2013
openaire   +1 more source

When Biology Meets Medicine: A Perspective on Foundation Models

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence, and foundation models in particular, are transforming life sciences and medicine. This perspective reviews biological and medical foundation models across scales, highlighting key challenges in data availability, model evaluation, and architectural design.
Kunying Niu, Yuxing Wang, Limin Zou, Jing Huang   +3 more
wiley   +1 more source

Induction of ROS-mediated genomic instability, mitochondrial deploarization and p53-independent mitochondrial apoptotic cell death by bioactive glass nanoparticles in human A431 epidermoid skin cancer cells. [PDF]

BMC Cancer
Mohamed HRH, Mosaad S, Osman AA, Elsewedy AH, Zaki HM, Borai ME, Safwat G.   +6 more
europepmc   +1 more source

Large‐Scale Machine Learning to Screen for Small‐Molecule Senolytics

Advanced Intelligent Discovery, EarlyView.
A consistent workflow underpins all experiments in this study. A dedicated model‐selection dataset first identifies optimal hyperparameters for each algorithm. Models are then trained and rigorously evaluated on independent sets of molecules using the senolytic ratio SR. Comprehensive hyperparameter exploration across SMILES representations, task types,
Alexis Dougha, Jesus Gil, Pedro J. Ballester   +2 more
wiley   +1 more source

Targeting ULK1 and USP20 to modulate autophagy and chemosensitivity in cancer cell lines. [PDF]

Biomed Rep
Abu Thiab T, Zihlif M, Alqudah D, Imraish A.   +3 more
europepmc   +1 more source

Pharmacological evaluation of Adenostemma lavenia acetone extract in Swiss Albino mice: Analgesic, anti‐inflammatory, and thrombolytic insights from in vivo, in vitro, density functional theory, and molecular docking studies

Animal Models and Experimental Medicine, EarlyView.
Adenostemma lavenia, a traditionally used medicinal plant, has been employed to manage pain, inflammation, and circulatory issues. This study investigates the analgesic, anti‐inflammatory, and thrombolytic potentials of the acetone extract of A. lavenia leaves (AEAL) using in vivo, in vitro, and in silico methods.
Nusrat Jahan Moon, Mahathir Mohammad, Md. Jahirul Islam Mamun, Fahmina Binty Azim Nova, Nazmul Hasan Eshaque, Md. Hossain Rasel, Zobayed Islam, Md. Mahmudul Hasan, Md. Liakot Ali, Md. Tanvir Chowdhury, S. M. Moazzem Hossen   +10 more
wiley   +1 more source