Results 1 to 10 of about 1,997,109 (329)

Total Raltegravir Concentrations in Cerebrospinal Fluid Exceed the 50-Percent Inhibitory Concentration for Wild-Type HIV-1 [PDF]

Antimicrobial Agents and Chemotherapy, 2010
ABSTRACT HIV-associated neurocognitive disorders continue to be common. Antiretrovirals that achieve higher concentrations in cerebrospinal fluid (CSF) are associated with better control of HIV and improved cognition. The objective of this study was to measure total raltegravir (RAL) concentrations in CSF and to compare them with
D. Croteau, S. Letendre, B. Best, Ronald J Ellis, S. Breidinger, D. Clifford, A. Collier, B. Gelman, C. Marra, Gilbert Mbeo, A. Mccutchan, S. Morgello, D. Simpson, Lauren Way, F. Vaida, Susan Ueland, E. Capparelli, I. Grant   +17 more
semanticscholar   +4 more sources

Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV

AIDS, 2005
Lopinavir (LPV) is highly bound to plasma proteins and is a substrate for active drugs transporters, which may greatly limit the access of LPV to the central nervous system (CNS). However, even low lopinavir concentrations may be sufficient to inhibit HIV replication.
E. Capparelli, D. Holland, Charles Okamoto, B. Gragg, J. Durelle, J. Marquie‐Beck, G. van den Brande, Ronald J Ellis, S. Letendre   +8 more
semanticscholar   +3 more sources

The changing 50% inhibitory concentration (IC50) of cisplatin: a pilot study on the artifacts of the MTT assay and the precise measurement of density-dependent chemoresistance in ovarian cancer

Oncotarget, 2016
Inconsistencies in the half-maximal (50%) inhibitory concentration (IC50) data for anticancer chemotherapeutic agents have yielded irreproducible experimental results and thus reciprocally contradictory theories in modern cancer research.
Yifeng He, Qiu-jing Zhu, Mo Chen, Qihong Huang, Wenjing Wang, Qing Li, Yuting Huang, W. Di   +7 more
semanticscholar   +4 more sources

Estimation of Serum-Free 50-Percent Inhibitory Concentrations for Human Immunodeficiency Virus Protease Inhibitors Lopinavir and Ritonavir [PDF]

Antimicrobial Agents and Chemotherapy, 2004
ABSTRACTUsing measured free fraction and 50% inhibitory concentration (IC50) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC50values for each drug.
D. Hickman, S. Vasavanonda, George Nequist, Lynn Colletti, W. Kati, R. Bertz, A. Hsu, D. Kempf   +7 more
semanticscholar   +3 more sources

Assessment of the Drug Susceptibility of Plasmodium falciparum Clinical Isolates from Africa by Using a Plasmodium Lactate Dehydrogenase Immunodetection Assay and an Inhibitory Maximum Effect Model for Precise Measurement of the 50-Percent Inhibitory Concentration [PDF]

Antimicrobial agents and chemotherapy, 2006
The extension of drug resistance among malaria-causing Plasmodium falciparum parasites in Africa necessitates implementation of new combined therapeutic strategies. Drug susceptibility phenotyping requires precise measurements. Until recently, schizont maturation and isotopic in vitro assays were the only methods available, but their use was limited by
H. Kaddouri, Serge Nakache, S. Houzé, F. Mentré, J. Le bras   +4 more
semanticscholar   +4 more sources

Minimum Inhibitory Concentration (MIC) Assay for Antifungal Drugs

Bio-Protocol, 2012
The Minimum Inhibitory Concentration (MIC) Assay is widely used to measure the susceptibility of yeasts to antifungal agents. In serial two-fold dilutions, the lowest concentration of antifungal drug that is sufficient to inhibit fungal growth is the MIC.
Lucy Xie, Sheena Singh-Babak, Leah Cowen   +2 more
doaj   +2 more sources

Quantitating immunosuppression. Estimating the 50% inhibitory concentration for in vivo cyclosporine in mice.

Transplantation, 1996
Cyclosporine (CsA) blocks T cell responses in vitro by inhibiting the phosphatase activity of calcineurin (CN) and thus preventing the activation of cytokine transcription. In the study presented here, we measured the extent of inhibition of these functions in the tissues of CsA-fed mice. Mice fed increasing doses of CsA were assessed for CsA blood and
T. Batiuk, J. Urmson, D. Vincent, R. Yatscoff, P. Halloran   +4 more
semanticscholar   +3 more sources

In vitro efficacy of chemotherapeutics as determined by 50% inhibitory concentrations in cell cultures of mammary gland tumors obtained from dogs.

American Journal of Veterinary Research, 2001
Abstract Objective—To determine the 50% inhibitory concentration (IC-50) of carboplatin, cisplatin, and doxorubicin in cell cultures of mammary gland tumors obtained from dogs and to assess whether in vitro efficacy was within the range of clinically relevant concentrations.
D. Simon, J. Knebel, W. Baumgärtner, M. Aufderheide, Andrea Meyer-Lindenberg, I. Nolte   +5 more
semanticscholar   +3 more sources

Anti-malarial investigation of Acorus calamus, Dichapetalum gelonioides, and Leucas aspera on Plasmodium falciparum strains

Journal of Infection in Developing Countries, 2022
Introduction: Malaria is a significant global health concern and adversely affects people in developing countries including Bangladesh. The causative agent Plasmodium falciparum is resistant to several currently available anti-malarial drugs, such as ...
Md Fahad Zamil, Saiful Arefeen Sazed, Muhammad Riadul Haque Hossainey, Anik Biswas, Mohammad Shafiul Alam, Hamida Khanum, Priyanka Barua   +6 more
doaj   +1 more source

Assessing Anti-malaria Effect of Naja Naja Oxiana Snake Venom by Real-time Polymerase Chain Reaction Method

Complementary Medicine Journal of Faculty of Nursing and Midwifery, 2021
Objective: Malaria is one of the most important parasitic diseases and one of the important health issues especially in tropical and subtropical countries.
Fatemeh Hajialiani, Sedigheh Sadeghi, Delavar Shahbazzadeh, Fatemeh Tabatabaie , Zahra Zamani   +4 more
doaj   +1 more source