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Computing Method and Test on IC50 Value of Tyrosinase Inhibition

Advanced Materials Research, 2014
Calculating methods of inhibitor concentration leading to yield 50% inhibition (IC50) of competitive inhibitor, noncompetitive inhibitor and mixed inhibitor were proposed on the basis of kinetics of enzyme inhibition, and were applied to calculate IC50 value of concerned compounds, such as cinnamic acid, cinnamaldehyde, benzoic acid and et al.
Sheng Zhao Gong   +2 more
openaire   +1 more source

Generation of Dose–Response Curves and Improved IC50s for PARP Inhibitor Nanoformulations

2017
Poly(ADP-ribose) polymerase (PARP) inhibitors that target DNA damage repair pathways in cancer cells are increasingly attractive for treating several cancers. Determining the half maximal inhibitory concentration (IC50) of these molecular inhibitors in cell lines is crucial for further dosing for in vivo experiments. Typically these in vitro assays are
Paige, Baldwin   +2 more
openaire   +2 more sources

AIC50: An Innovative Machine Learning Approach to Precise IC50 Prediction

Advances in Multidisciplinary & Scientific Research Journal Publication
The half-maximal inhibitory concentration (IC50) is a critical metric in pharmacology, used to evaluate a compound's potency by indicating the concentration needed to inhibit a biological target by fifty percent. Accurate IC50 measurement is essential for drug discovery, yet traditional experimental assays are costly and time-consuming, limiting their ...
E.D Obi   +3 more
openaire   +1 more source

[Study on cytotoxicity tests of medical devices based on IC50].

Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation, 2015
To discuss IC50 application in cytotoxicity tests of medical devices, we firstly investigated the vibrating condition and endpoint of MTT method specified in ISO 10993-5: 2009. Furthermore, we demonstrated the application of IC50 in the result evaluation of MTT method.
Chenghu, Liu   +5 more
openaire   +1 more source

Use of standardized units for a correct interpretation of IC50 values obtained from the inhibition of the DPPH radical by natural antioxidants

Chemical Papers, 2020
Flavio Martinez-Morales   +2 more
exaly  

IC50

2011
openaire   +1 more source

Comparability of Mixed IC50 Data – A Statistical Analysis

PLoS ONE, 2013
Tuomo Kalliokoski   +2 more
exaly  

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