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Computing Method and Test on IC50 Value of Tyrosinase Inhibition
Advanced Materials Research, 2014Calculating methods of inhibitor concentration leading to yield 50% inhibition (IC50) of competitive inhibitor, noncompetitive inhibitor and mixed inhibitor were proposed on the basis of kinetics of enzyme inhibition, and were applied to calculate IC50 value of concerned compounds, such as cinnamic acid, cinnamaldehyde, benzoic acid and et al.
Sheng Zhao Gong +2 more
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Generation of Dose–Response Curves and Improved IC50s for PARP Inhibitor Nanoformulations
2017Poly(ADP-ribose) polymerase (PARP) inhibitors that target DNA damage repair pathways in cancer cells are increasingly attractive for treating several cancers. Determining the half maximal inhibitory concentration (IC50) of these molecular inhibitors in cell lines is crucial for further dosing for in vivo experiments. Typically these in vitro assays are
Paige, Baldwin +2 more
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AIC50: An Innovative Machine Learning Approach to Precise IC50 Prediction
Advances in Multidisciplinary & Scientific Research Journal PublicationThe half-maximal inhibitory concentration (IC50) is a critical metric in pharmacology, used to evaluate a compound's potency by indicating the concentration needed to inhibit a biological target by fifty percent. Accurate IC50 measurement is essential for drug discovery, yet traditional experimental assays are costly and time-consuming, limiting their ...
E.D Obi +3 more
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[Study on cytotoxicity tests of medical devices based on IC50].
Zhongguo yi liao qi xie za zhi = Chinese journal of medical instrumentation, 2015To discuss IC50 application in cytotoxicity tests of medical devices, we firstly investigated the vibrating condition and endpoint of MTT method specified in ISO 10993-5: 2009. Furthermore, we demonstrated the application of IC50 in the result evaluation of MTT method.
Chenghu, Liu +5 more
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Comparability of Mixed IC50 Data – A Statistical Analysis
PLoS ONE, 2013Tuomo Kalliokoski +2 more
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