Results 1 to 10 of about 159,080 (332)

ICAM-1 Deficiency in the Bone Marrow Niche Impairs Quiescence and Repopulation of Hematopoietic Stem Cells [PDF]

Stem Cell Reports, 2018
Summary: The bone marrow niche plays a critical role in controlling the fate of hematopoietic stem cells (HSCs) by integrating intrinsic and extrinsic signals. However, the molecular events in the HSC niche remain to be investigated. Here, we report that
Yu-feng Liu, Shao-ying Zhang, Ying-ying Chen, Kun Shi, Bin Zou, Jun Liu, Qiong Yang, Hua Jiang, Lai Wei, Chang-zheng Li, Meng Zhao, Dmitry I. Gabrilovich, Hui Zhang, Jie Zhou   +13 more
doaj   +2 more sources

ICAM-1 promotes cancer progression by regulating SRC activity as an adapter protein in colorectal cancer [PDF]

Cell Death and Disease, 2022
Colorectal cancer (CRC) has a 5-year survival rate of
Eun-Ji Lim, Jae-Hyeok Kang, Yeon-Ju Kim, Seungmo Kim, Su-Jae Lee   +4 more
doaj   +2 more sources

Neoplastic ICAM-1 protects lung carcinoma from apoptosis through ligation of fibrinogen [PDF]

Cell Death and Disease
Intercellular cell adhesion molecule-1 (ICAM-1) is frequently overexpressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis. However, the mechanism underlying the negative effects of neoplastic ICAM-1 remains obscure.
ShiHui Wang, JunLei Wang, Cui Liu, Lei Yang, XuanQian Tan, ShiYang Chen, Yun Xue, HongBin Ji, GaoXiang Ge, JianFeng Chen   +9 more
doaj   +2 more sources

Role of ICAM-1 in triple-negative breast cancer [PDF]

Open Medicine
Intercellular adhesion molecule-1 (ICAM-1) is related to the occurrence and development of a variety of tumors. However, the role of ICAM-1 in the regulation of growth, metastasis, and clinical prognosis of the specific molecular subtypes of breast ...
Zhang Ying, Fan Jingjing, Wang Xiaoli, Wu Zhongyu, Ma Weiqiang, Ma Binlin   +5 more
doaj   +2 more sources

Association of intercellular adhesion molecule 1 (ICAM-1) (rs5498) genetic polymorphism and dengue in Sabah East Malaysia population. [PDF]

Mol Biol Rep
Guad RM, Aung YN, Taylor-Robinson AW, Silvester C, Sim MS, Gee LH, Seng WY, Sekaran SD, Azizan N.   +8 more
europepmc   +3 more sources

Cilomilast Modulates Rhinovirus-Induced Airway Epithelial ICAM-1 Expression and IL-6, CXCL8 and CCL5 Production. [PDF]

Pharmaceuticals (Basel)
Zhu J, Edwards MR, Message SD, Stanciu LA, Johnston SL, Jeffery PK.   +5 more
europepmc   +3 more sources

ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo

Frontiers in Immunology, 2021
Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte
Deborah L. W. Chong, Carine Rebeyrol, Ricardo J. José, Andrew E. Williams, Jeremy S. Brown, Chris J. Scotton, Chris J. Scotton, Joanna C. Porter   +7 more
doaj   +1 more source

Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. [PDF]

PLoS ONE, 2010
BackgroundDuring transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukocytes.
Jaap D van Buul, Jos van Rijssel, Floris P J van Alphen, Mark Hoogenboezem, Simon Tol, Kees A Hoeben, Jan van Marle, Erik P J Mul, Peter L Hordijk   +8 more
doaj   +1 more source

Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCα in human microvascular endothelial cells. [PDF]

PLoS ONE, 2012
ICAM-1-dependent leukocyte recruitment in vivo is inhibited by the vitamin E isoform d-α-tocopherol and elevated by d-γ-tocopherol. ICAM-1 is reported to activate endothelial cell signals including protein kinase C (PKC), but the PKC isoform and the ...
Hiam Abdala-Valencia, Sergejs Berdnikovs, Joan M Cook-Mills   +2 more
doaj   +1 more source

ICAM-1: Isoforms and Phenotypes [PDF]

The Journal of Immunology, 2014
Abstract ICAM-1 plays an important role in leukocyte trafficking, immunological synapse formation, and numerous cellular immune responses. Although considered a single glycoprotein, there are multiple membrane-bound and soluble ICAM-1 isoforms that arise from alternative splicing and proteolytic cleavage during inflammatory responses ...
Theresa N, Ramos, Daniel C, Bullard, Scott R, Barnum   +2 more
openaire   +2 more sources