Results 91 to 100 of about 21,323,950 (308)

Association of Ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2) [PDF]

, 1998
Ezrin is a cytoplasmic linker molecule between plasma membrane components and the actin-containing cytoskeleton. We studied whether ezrin is associated with intercellular adhesion molecule (ICAM)-1, -2, and -3.
Pekka Vilja, Vaheri, Antti, Kaija Alfthan, Olli Carpén, Grönholm, Mikaela, Antti Vaheri, Carpén, Olli, Mikaela Grönholm, Alfthan, Kaija, Vilja, Pekka, Heiska, Leena, Leena Heiska   +11 more
core   +1 more source

Neoplastic ICAM-1 protects lung carcinoma from apoptosis through ligation of fibrinogen

Cell Death and Disease
Intercellular cell adhesion molecule-1 (ICAM-1) is frequently overexpressed in non-small cell lung cancer (NSCLC) and associated with poor prognosis. However, the mechanism underlying the negative effects of neoplastic ICAM-1 remains obscure.
ShiHui Wang, JunLei Wang, Cui Liu, Lei Yang, XuanQian Tan, ShiYang Chen, Yun Xue, HongBin Ji, GaoXiang Ge, JianFeng Chen   +9 more
doaj   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Lactation is Associated with Accelerated Postpartum Pelvic Floor Muscle Recovery in a Pregnant Simulated Birth Injury Model

Advanced Science, EarlyView.
ABSTRACT Healthy pelvic floor muscles (PFMs) are essential for proper pelvic floor function. The biggest risk factor for PFM dysfunction is injury sustained during vaginal childbirth, yet the factors that facilitate or impair PFM recovery from birth injury remain unknown.
Bianca L. Peña, Khushi M. Diwakar, Hillary K. Tran, Selena Cao, Celeste E. Lintz, Laila N. Hayes, Marianna Alperin, Karen L. Christman   +7 more
wiley   +1 more source

Role of ICAM-1 and E-selectin gene polymorphisms in pathogenesis of PAOD in Egyptian patients [PDF]

, 2009
Olfat Shaker1, Amr Zahra2, Ahmed Sayed3, Ayman Refaat4, Zakaria El-Khaiat5, Gehan Hegazy5, Khaled El-Hindawi3, Mohamed Ay-El Deen31Department of Medical Biochemistry, 3Vascular Surgery, Faculty of Medicine, Cairo University, Cairo, Egypt; 2Department of ...
Ahmed Sayed, Amr Zahra, Olfat Shaker, et al   +3 more
core  

ICAM-1, ICAM-2 and ICAM-3 in the sera of patients with idiopathic pulmonary fibrosis [PDF]

, 2004
In order to test the serum levels of ICAM-1, ICAM-2 and ICAM-3 in patients with idiopathic pulmonary fibrosis (IPF), twenty patients with IPF and eleven with secondary interstitial fibrosis (SIF), as well as forty healthy volunteers (HV) were studied ...
Antonios Maniatis, Gourgoulianis, K. I., Molyvdas, P. A., Pashalis Adam Molyvdas, Efremidou, S., Maria Mpaka, Tsoutsou, P. G., Konstantinos I. Gourgoulianis, Efthymia Petinaki, Smaragda Efremidou, Pelagia G. Tsoutsou, Maniatis, A., Mpaka, M., Petinaki, E.   +13 more
core   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, EarlyView.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source

Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

Frontiers in Molecular Neuroscience, 2017
The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro.
Sonja Paetau, Taisia Rolova, Lin Ning, Carl G. Gahmberg   +3 more
doaj   +1 more source

ICAM-1 and Nanomedicine [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2012
Ligand-targeted nanomedicines, particularly those directed to vascular-accessible biomarkers,1,2 have evolved from fanciful concepts 25 years ago to product concepts now near or in clinical trials. While numerous chemical and biological barriers have been discovered and broached over this time frame, perhaps the single greatest challenge to success of ...
openaire   +2 more sources

Inhibition of KDEL Receptors Remodels the Tumor Microenvironment for T Cell Independent Tumor Regression

Advanced Science, EarlyView.
Inhibition of KDELR2 in a small fraction of tumor cells generates sustainable immunogenic cell death conditions within the tumor microenvironment. These conditions promote the regression of tumors in a T cell independent manner. During regression, macrophages prime T cells that subsequently provide systemic protection against recurrence. The potency of
Shakti P Pattanayak, Hong Wang, Belinda Willard, Timothy A. Chan, William C Merrick, Zheng‐Rong Lu, Boaz Tirosh   +6 more
wiley   +1 more source