Results 101 to 110 of about 21,323,950 (308)

Force Spectroscopy of LFA-1 and Its Ligands, ICAM-1 and ICAM-2 [PDF]

, 2006
Single-molecule measurements of the interaction of leukocyte function- associated antigen-1 (LFA-1), expressed on Jurkat T cells, with intercellular adhesion molecules-1 and -2 (ICAM-1 and ICAM-2) were conducted using atomic force microscopy (AFM).
Xiaohui Zhang, Zhang, Xiaohui, Abdulreda, Midhat H, Moy, Vincent T, Vincent T. Moy, Ewa P. Wojcikiewicz, Wojcikiewicz, Ewa P, Midhat H. Abdulreda   +7 more
core   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

HLA-DR and intercellular adhesion molecule (ICAM)-1 expression in leprosy skin lesions [PDF]

, 2011
Copyright information:Taken from "Increased Langerhans cell accumulation after mycobacterial stimuli"Histopathology 2007;51(5):649-656.Published online Jan 2007PMCID:PMC2121149.© 2007 The Authors. Journal compilation © 2007 Blackwell Publishing Limited.
T P Amadeu (37330), G Schueler (37331), H Ferreira (37334), J A C Nery (37335), A Miranda (37329), E N Sarno (37336), F B F Alvarenga (37332), N Duppré (37333)   +7 more
core   +1 more source

Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium

Respiratory Research, 2016
Background Microparticles (MPs) stimulate inflammatory adhesion molecule expression in systemic vascular diseases, however it is unknown whether circulating MPs stimulate localized ICAM-1 expression in the heterogeneically distinct pulmonary endothelium ...
Leslie A. Blair, April K. Haven, Natalie N. Bauer   +2 more
doaj   +1 more source

Slc44a2 Deficiency Unveils an IFN‐I–Dependent Feedback Control of pDC Egress

Advanced Science, EarlyView.
Working model of SLC44A2‐mediated maintenance of pDC homeostasis. This model illustrates two central mechanisms by which SLC44A2 regulates pDC homeostasis: (1) SLC44A2 limits IFN‐I production by exporting amino acids (T, N, Q), thereby preventing spontaneous pDC activation.
Ruiqun Chen, Tao Wu, Zhen Shi, Ravi Kumar Verma, Linlin Sheng, Lei Tao, Mingming Yang, Yuchen Wang, Conggang Zhang, Hao Fan, Li Wu, Ligong Chen   +11 more
wiley   +1 more source

Beyond Simple Mimicry: Next‐Generation Geometric Architectures and Future Paradigms in Small‐Molecule and Macrocyclic Peptidomimetics

Angewandte Chemie, EarlyView.
Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee, Sumin Son, Jeong Yeon Yoo, Ji Hyae Lee, Meehyun Chun, Seung Bum Park   +5 more
wiley   +2 more sources

ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke. [PDF]

, 2018
Accumulation of neutrophils in the brain is a hallmark of cerebral ischemia and considered central in exacerbating tissue injury. Intercellular adhesion molecule (ICAM)-1 is upregulated on brain endothelial cells after ischemic stroke and considered ...
Pavlidou, Sofia, Enzmann, Gaby U., Enzmann, Gaby, Markus Vaas, Gaby U. Enzmann, Jan Klohs, Engelhardt, Britta, Britta Engelhardt, Klohs, Jan, Sofia Pavlidou, Vaas, Markus   +10 more
core   +2 more sources

Blockade of ICAM-1 Improves the Outcome of Polymicrobial Sepsis via Modulating Neutrophil Migration and Reversing Immunosuppression

Mediators of Inflammation, 2014
Intercellular adhesion molecule-1 (ICAM-1) is a key adhesion molecule mediating neutrophil migration and infiltration during sepsis. But its role in the outcome of sepsis remains contradictory.
Yan-jun Zhao, Wen-jing Yi, Xiao-jian Wan, Jun Wang, Tian-zhu Tao, Jin-bao Li, Jia-feng Wang, Xiao-ming Deng   +7 more
doaj   +1 more source

HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy.

PLoS ONE, 2013
Cardiac involvement is a well-documented complication of human immunodeficiency virus-1 (HIV-1) infection. Previous studies have demonstrated increased adhesion of monocytes to human vascular endothelial cells in HIV-infected individuals. HIV Tat protein,
Ming Duan, Honghong Yao, Guoku Hu, XianMing Chen, Amie K Lund, Shilpa Buch   +5 more
doaj   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source