Results 111 to 120 of about 21,323,950 (308)

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Angiogenesis⁃ related factors expression in oral lichen planus

口腔疾病防治, 2017
Objective To detect the expression of vascular endothelial growth factor (VEGF), intercellular adhesion molecule⁃1 (ICAM⁃1), vascular cell adhesion molecule⁃1 (VCAM⁃1) in oral lichen planus (OLP).
LI Juxiong
doaj   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

Advanced Science, EarlyView.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He, Qiannan Ma, Xue Wang, Jiaxu Mang, Chufeng Li, Bingjun Wu, Liu Yao, Yequn Chen, Qiankun Bao, Yi Zhu, Jinlong He   +10 more
wiley   +1 more source

MOESM1 of Anti-ICAM-1 antibody-modified nanostructured lipid carriers: a pulmonary vascular endothelium-targeted device for acute lung injury therapy [PDF]

, 2018
Additional file 1: Figure S1. Cellular uptake of dexamethasone-loaded NLCs in quiescent EAs detected by fluorescence microscope (bar = 100 μm). Figure S2. Cellular uptake of dexamethasone-loaded NLCs in quiescent EAs detected by flow cytometry. Figure S3.
Li Chen (5749), Guokang Wang (6164483), Lexing Xu (1658626), Ziwei Chen (626412), Fuhe Liu (4736781), Shanshan Hou (5999507), Xiaojuan Wang (105141), Xiaoling Xu (17877), Yong-Zhong Du (2049142), Shujuan Li (523002)   +9 more
core   +1 more source

THSD7A Exacerbates Atherosclerosis via Activation of Signaling Axis αvβ3/CEBPD/IL1A

Advanced Science, EarlyView.
THSD7A exerts pro‐inflammatory effects and exacerbates atherosclerosis. Mechanistically, THSD7A regulates endothelial cell inflammation and atherosclerosis by activating the αvβ3/CEBPD/IL1A signaling axis. THSD7A is not only a genetic marker but also a potential therapeutic target for coronary artery disease (CAD).
Jiankun Liu, Hongfei Liu, Yiqi Wan, Andong Wu, Jiayu Qiu, Xueting Gong, Ya Zhao, Yuanyuan Li, Bingbing Zhou, Yangyi Zheng, Fang Wu, Yuanzheng Zhu, Weixin Lv, Xueer Li, Qiang Yuan, Xiao‐Li Tian   +15 more
wiley   +1 more source

Biodistribution and endocytosis of ICAM-1-targeting antibodies versus nanocarriers in the gastrointestinal tract in mice [PDF]

, 2012
Viraj Mane,1 Silvia Muro1, 21Institute for Bioscience and Biotechnology Research, 2Fischell Department of Bioengineering, University of Maryland, College Park, MD, USAAbstract: Drug delivery to the gastrointestinal (GI) tract is key for improving ...
Muro S, Mane V
core  

Sub-acute treatment of rats with dexamethasone reduces ICAM-1 levels on circulating monocytes [PDF]

, 1997
We report for the first time thatin vivotreatment with dexamethasone (DEX) reduces levels of intercellular adhesion molecule-1 (ICAM-1) expression on rat circulating unstimulated monocytes (−55%) and peritoneal macrophages (−26%). This effect was present
Das, A.M., Tailor, A., Perretti, M., Flower, R.J., Getting, S.J.   +4 more
core   +1 more source

The Predictive Value of Endothelial Inflammatory Markers in the Onset of Schizophrenia

Neuropsychiatric Disease and Treatment, 2020
Gabriela Radu,1,2,* Constantin Luca,3,* Lucian Petrescu,3,* Diana Aurora Bordejevic,2,3,* Mirela Cleopatra Tomescu,1,2 Minodora Andor,1,2 Ioana Cîtu,1,2 Adelina Mavrea,1,2 Valentina Buda,4 Cătălin Tomescu,1,2 Florin Borcan,4 Liana Dehelean5 ...
Radu G, Luca C, Petrescu L, Bordejevic DA, Tomescu MC, Andor M, Cîtu I, Mavrea A, Buda V, Tomescu C, Borcan F, Dehelean L   +11 more
doaj  

Chinese Expert Consensus on the Clinical Application of Finerenone in Geriatric Comorbidities

AGING MEDICINE, EarlyView.
Mineralocorticoid receptor (MR) overactivation drives inflammation, oxidative stress, and fibrosis in the heart, kidneys, and vasculature, leading to cardiorenal dysfunction. MR signaling promotes hypertrophy, remodeling, and injury through pathways like oxidative stress and inflammation, resulting in vascular stiffness and progressive organ damage ...
Xiaoming Wang, Cuntai Zhang
wiley   +1 more source

ICAM-1 up-regulation in irradiated RECs. [PDF]

, 2014
A) Immunoblotting of ICAM-1 from IR-RECs after 24 hours show a significant up-regulation compared to unirradiated cells; treatment with KZ-41 (10 µM) reduces ICAM-1 levels by nearly 24% (Mean ± SD ...
Jena J. Steinle (436932), Christopher M. Waters (148727), Duane D. Miller (238777), Charles R. Yates (582296), Jordan J. Toutounchian (582292), Matthew W. Wilson (582294), Barrett G. Haik (582295), Patrudu S. Makena (582293)   +7 more
core   +1 more source