Results 111 to 120 of about 27,302,336 (342)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

ICAM-1 suppresses tumor metastasis by inhibiting macrophage M2 polarization through blockade of efferocytosis

Cell Death and Disease, 2015
Efficient clearance of apoptotic cells (efferocytosis) can profoundly influence tumor-specific immunity. Tumor-associated macrophages are M2-polarized macrophages that promote key processes in tumor progression.
M. Yang, Jing Liu, C. Piao, J. Shao, Jie Du   +4 more
semanticscholar   +1 more source

Динаміка інтенсивності лейкореї, сироваткових концентрацій адгезинів ICAM-1 та VCAM-1 під впливом антимікробної терапії у чоловіків з первинним та рецидивним монобактеріальним гострим уретритом, спричиненим C. trachomatis, M. genitalium та U. urealyticum [PDF]

, 2015
За участю 180 пацієнтів дослідженно зв’язки між вмістом молекул межклітинної адгезії ICAM-1, VCAM-1, уретральною лейкореєю, сумарним балом уретральних симптомів, а також динаміка цих показників у процесі ерадикації антигенів під дією антимікробних ...
Анфілова, М.Р.
core  

A well-conserved Plasmodium falciparum var gene shows an unusual stage-specific transcript pattern [PDF]

, 2003
The var multicopy gene family encodes Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variant antigens, which, through their ability to adhere to a variety of host receptors, are thought to be important virulence factors.
Sue A. Kyes, Zoe Christodoulou, Ahmed Raza, Paul Horrocks, Robert Pinches, J. Alexandra Rowe, Chris I. Newbold, Aguiar, Baruch, Beeson, Berendt, Bonnefoy, Brabin, Buffet, Bull, Chen, Chen, Church, Duffy, Fidock, Fowler, Freitas-Junior, Fried, Fried, Fried, Gardner, Gardner, Goda, Kyes, Kyes, Lambros, Lekana Douki, Marsh, Newbold, Pouvelle, Reeder, Ricke, Roberts, Robson, Rowe, Rowe, Rubio, Salanti, Scherf, Smith, Smith, Smith, Su, Taylor, Trager, Vazquez-Macias, Voss   +51 more
core   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Neuronal ICAM-5 Inhibits Microglia Adhesion and Phagocytosis and Promotes an Anti-inflammatory Response in LPS Stimulated Microglia

Frontiers in Molecular Neuroscience, 2017
The intercellular adhesion molecule-5 (ICAM-5) regulates neurite outgrowth and synaptic maturation. ICAM-5 overexpression in the hippocampal neurons induces filopodia formation in vitro.
Sonja Paetau, Taisia Rolova, Lin Ning, Carl G. Gahmberg   +3 more
doaj   +1 more source

Characterization of the murine Icam-1 gene

Genomics, 1992
Intercellular adhesion molecule-1 (ICAM-1, CD54) is a cell adhesion molecule that interacts with the leukocyte beta 2 integrins, LFA-1 and Mac-1. Murine inflammatory models are being utilized increasingly to define the role that ICAM-1 induction plays in the initiation of inflammation. We have isolated murine genomic clones that contain the Icam-1 gene
C M, Ballantyne, J E, Sligh, X Y, Dai, A L, Beaudet   +3 more
openaire   +2 more sources

Regulation of ICAM-1 in Cells of the Monocyte/Macrophage System in Microgravity

BioMed Research International, 2015
Cells of the immune system are highly sensitive to altered gravity, and the monocyte as well as the macrophage function is proven to be impaired under microgravity conditions.
K. Paulsen, S. Tauber, C. Dumrese, G. Bradacs, Dana M Simmet, N. Gölz, Swantje Hauschild, C. Raig, Stephanie Engeli, Annett Gutewort, E. Hürlimann, Josefine Biskup, F. Unverdorben, G. Rieder, Daniel Hofmänner, Lisa Mutschler, Sonja Krammer, Isabell Buttron, C. Philpot, A. Huge, Hartwin Lier, Ines Barz, F. Engelmann, L. E. Layer, C. Thiel, O. Ullrich   +25 more
semanticscholar   +1 more source

Biomimetic Cell Membrane‐Coated MOFs System for Targeted Cancer Therapy

Advanced Science, EarlyView.
Biomimetic MOF‐based drug delivery nanoplatforms synthesized using liposomes or cell membranes as camouflage for multiple cancer therapeutics. ABSTRACT The integration of metal‐organic frameworks (MOFs) with cell membrane coatings has emerged as a revolutionary strategy to enhance the therapeutic efficacy of cancer nanomedicine.
Qilu Wu, Jia Song Deon Chon, Yuxiao Feng, Kang Liang, Shiming Li, Can Yang Zhang, Jun Ge   +6 more
wiley   +1 more source

Angiotensin-(1-7) Attenuates Angiotensin II-Induced ICAM-1, VCAM-1, and MCP-1 Expression via the MAS Receptor Through Suppression of P38 and NF-κB Pathways in HUVECs

Cellular Physiology and Biochemistry, 2015
Background/Aims: Atherosclerosis is a chronic inflammatory disease. Intracellular adhesion molecule-1 (ICAM-1), vascular cellular adhesion molecule-1 (VCAM-1), and monocyte chemoattractant protein-1 (MCP-1) play important roles in inflammatory processes.
B. Liang, Xin Wang, N. Zhang, Huiyu Yang, R. Bai, Ming Liu, Yun-fei Bian, C. Xiao, Zhi-ming Yang   +8 more
semanticscholar   +1 more source