Results 21 to 30 of about 27,302,336 (342)
Frontiers in Immunology, 2021 Neutrophil migration into the airways is an important process to fight infection and is mediated by cell adhesion molecules. The intercellular adhesion molecules, ICAM-1 (CD54) and ICAM-2 (CD102) are known ligands for the neutrophil integrins, lymphocyte
Deborah L. W. Chong +7 more
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Inside-out regulation of ICAM-1 dynamics in TNF-alpha-activated endothelium. [PDF]
PLoS ONE, 2010 BackgroundDuring transendothelial migration, leukocytes use adhesion molecules, such as ICAM-1, to adhere to the endothelium. ICAM-1 is a dynamic molecule that is localized in the apical membrane of the endothelium and clusters upon binding to leukocytes.
Jaap D van Buul +8 more
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Journal of Leukocyte Biology, 2020 ICAM‐1 is a cell surface glycoprotein and an adhesion receptor that is best known for regulating leukocyte recruitment from circulation to sites of inflammation.
Triet M. Bui +2 more
semanticscholar +1 more source
Vitamin E isoforms differentially regulate intercellular adhesion molecule-1 activation of PKCα in human microvascular endothelial cells. [PDF]
PLoS ONE, 2012 ICAM-1-dependent leukocyte recruitment in vivo is inhibited by the vitamin E isoform d-α-tocopherol and elevated by d-γ-tocopherol. ICAM-1 is reported to activate endothelial cell signals including protein kinase C (PKC), but the PKC isoform and the ...
Hiam Abdala-Valencia +2 more
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Skeletal muscle cells express ICAM-1 after muscle overload and ICAM-1 contributes to the ensuing hypertrophic response. [PDF]
PLoS ONE, 2013 We previously reported that leukocyte specific β2 integrins contribute to hypertrophy after muscle overload in mice. Because intercellular adhesion molecule-1 (ICAM-1) is an important ligand for β2 integrins, we examined ICAM-1 expression by murine ...
Christopher L Dearth +7 more
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Role of the intercellular adhesion molecule-1(ICAM-1) in endotoxin-induced pneumonia evaluated using ICAM-1 antisense oligonucleotides, anti-ICAM-1 monoclonal antibodies, and ICAM-1 mutant mice. [PDF]
Journal of Clinical Investigation, 1996 This study examined the effectiveness of antisense oligonucleotides targeted to intercellular adhesion molecule-1 (ICAM-1) to inhibit endotoxin-induced upregulation of ICAM-1 and neutrophil emigration and compared the apparent role of ICAM-1 when examined using antisense oligonucleotides, anti-ICAM-1 antibodies, and ICAM-1 mutant mice.
T, Kumasaka +8 more
openaire +2 more sources
ICAM-1 functions as an efferocytosis receptor in inflammatory macrophages.
American Journal of Pathology, 2020 Intercellular adhesion molecule-1 (ICAM-1) is upregulated during inflammation by several cell types. ICAM-1 is best known for its role in mediating leukocyte adhesion to endothelial cells and guiding leukocytes across the vascular wall.
Hannah L. Wiesolek +7 more
semanticscholar +1 more source
Extracellular CIRP and TREM‐1 axis promotes ICAM‐1‐Rho‐mediated NETosis in sepsis
The FASEB Journal, 2020 Extracellular cold‐inducible RNA‐binding protein (eCIRP) is a damage‐associated molecular pattern (DAMP). Intercellular adhesion molecule‐1 (ICAM‐1) expressing neutrophils produce excessive amounts of neutrophil extracellular traps (NETs). We reveal that
Atsushi Murao +8 more
semanticscholar +1 more source
BMC Research Notes, 2018 Objective Regulation of intercellular adhesion molecule (ICAM)-1 in retinal endothelial cells is a promising druggable target for retinal vascular diseases.
Amanda L. Lumsden +6 more
doaj +1 more source
Frontiers in Immunology, 2020 In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), myelin-specific T cells are activated in the periphery and differentiate in T helper (Th) 1 and Th17 effector cells, which cross the blood-brain barrier (BBB)
Neda Haghayegh Jahromi +12 more
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