ICAM‐1‐targeted nanocarriers attenuate endothelial release of soluble ICAM‐1, an inflammatory regulator [PDF]
Bioengineering & Translational Medicine, 2017 AbstractTargeting of drug nanocarriers (NCs) to intercellular adhesion molecule‐1 (ICAM‐1), an endothelial‐surface protein overexpressed in many pathologies, has shown promise for therapeutic delivery into and across this lining. However, due to the role of ICAM‐1 in inflammation, the effects of targeting this receptor need investigation.
Manthe, Rachel L., Muro, Silvia
openaire +2 more sources
Transfected HEK293 cells expressing functional recombinant intercellular adhesion molecule 1 (ICAM-1)--a receptor associated with severe Plasmodium falciparum malaria. [PDF]
PLoS ONE, 2013 Intercellular adhesion molecule 1 (ICAM-1) is a membrane-bound glycoprotein expressed on endothelial cells and cells of the immune system. Human ICAM-1 mediates adhesion and migration of leucocytes, and is implicated in inflammatory pathologies ...
Anja Bengtsson +5 more
doaj +1 more source
Circulating adhesion molecules and arterial stiffness [PDF]
, 2015 Aim: VCAM-1 and ICAM-1 are two important members of the immunoglobulin gene superfamily of adhesion molecules, and their potential role as biomarkers of diagnosis, severity and prognosis of cardiovascular disease has been investigated in a number of ...
Alihanoglu, Y.I. +6 more
core +2 more sources
Cytoadherence and virulence - the case of Plasmodium knowlesi malaria. [PDF]
, 2012 BACKGROUND: Cytoadherence of infected red blood cells to brain endothelium is causally implicated in malarial coma, one of the severe manifestations of falciparum malaria.
Ahmed, A +7 more
core +5 more sources
Journal of Ovarian Research, 2019 Background Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disorder characterized by obesity, hyperandrogenism, and insulin resistance.
Nearmeen M. Rashad +9 more
doaj +1 more source
ICAM-1 and S100β plasma value in children with sepsis
Jurnal Profesi Medika, 2020 ICAM-1 release during sepsis is perceived to be related to brain injury. Whereas S100β has been known as one of brain injury markers.To measure mean value of ICAM-1, S100β, to find correlation between ICAM-1 and Glasgow Coma Scale (GCS), between S100β ...
Lisa Safira +2 more
doaj +1 more source
ICAM G241A polymorphism and soluble ICAM-1 serum levels: Evidence for an active immune process in schizophrenia [PDF]
, 2005 Objectives: We have previously reported reduced serum levels of soluble intercellular adhesion molecule-1 (sICAM-1) in schizophrenic patients. A single-nucleotide polymorphism ( SNP) of the ICAM-1 gene was described at position 241.
Ackenheil, Manfred +6 more
core +1 more source
Wound Healing Characteristics of ICAM-1 Null Mice Devoid of All Isoforms of ICAM-1 [PDF]
Journal of Surgical Research, 2011 Intercellular adhesion molecule-1 (ICAM-1) permits leukocyte-endothelial adhesion and transmigration during inflammation. Membrane-bound ICAM-1 knockout mice have been used to understand this molecule's role in wound-healing, but expressed spliced isoforms of ICAM-1 that may have impacted results.
Andre N, Gay +7 more
openaire +2 more sources
Endothelial MAPKs Direct ICAM-1 Signaling to Divergent Inflammatory Functions. [PDF]
, 2017 Lymphocyte transendothelial migration (TEM) is critically dependent on intraendothelial signaling triggered by adhesion to ICAM-1. Here we show that endothelial MAPKs ERK, p38, and JNK mediate diapedesis-related and diapedesis-unrelated functions of ICAM-
Adamson, P +10 more
core +2 more sources
Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]
, 2000 Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T. +11 more
core +1 more source