Results 71 to 80 of about 24,268 (294)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

New organic-walled dinoflagellate cysts from recent sediments of central Asian seas [PDF]

, 2004
Recent to sub-recent sediments from the Caspian Sea, the Kara-Bogaz-Gol Bay, the Enseli lake and the Aral Sea contain the new organic-walled dinoflagellate cysts Caspidinium, Caspidinium rugosum and Impagidinium caspienense.
Chalié, F, Gasse, F, Leroy, SAG, Marret, F   +3 more
core   +1 more source

Thermal Sidewall Ice Corer (TSIC) to recover samples from boreholes drilled in glaciers and ice sheets

Journal of Glaciology
The proposed Thermal Sidewall Ice Corer (TSIC) is designed to accurately sample horizontal ice layers of scientific interest, such as tephra layers, basal ice and shear zones, and retrieve ice cores back to the surface. The system features a bending core
Xianzhe Wei, Pavel G. Talalay, Da Gong, Yazhou Li, Xiaopeng Fan, Gaoli Zhao   +5 more
doaj   +1 more source

Characteristics of ice rises and ice rumples in Dronning Maud Land and Enderby Land, Antarctica

Journal of Glaciology, 2020
Ice rises and rumples, locally grounded features adjacent to ice shelves, are relatively small yet play significant roles in Antarctic ice dynamics. Their roles generally depend upon their location within the ice shelf and the stage of the ice-sheet ...
Vikram Goel, Kenichi Matsuoka, Cesar Deschamps Berger, Ian Lee, Jørgen Dall, René Forsberg   +5 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Lingulodinium machaerophorum expansion over the last centuries in the Caspian Sea reflects global warming [PDF]

, 2012
This article is made available through the Brunel Open Access Publishing Fund. Copyright @ Author(s) 2012. This work is distributed under the Creative Commons Attribution 3.0 License.We analysed dinoflagellate cyst assemblages in four short sediment ...
Arpe, K, Chalié, F, Habibi, P, Haghani, S, Lahijani, HAK, Leroy, SAG, Makhlough, A, Nasrollahzadeh, HS, Reyss, J-L, Shah-Hosseini, M, Shahkarami, S, Tudryn, A   +11 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Northern Hemisphere Glaciation during the Globally Warm Early Late Pliocene [PDF]

, 2013
The early Late Pliocene (3.6 to ~3.0 million years ago) is the last extended interval in Earth's history when atmospheric CO2 concentrations were comparable to today's and global climate was warmer.
DeSchepper, Stijn, Groeneveld, J, Head, M, Hennissen, Jan, Karl, Fabian, Louwye, Stephen, Naafs, B D A, Renterghem, Cédéric   +7 more
core   +6 more sources

What Lies Beneath? Interdisciplinary Outcomes of the ANDRILL Coulman High Project Site Surveys on the Ross Ice Shelf [PDF]

Oceanography, 2012
Extensive field operations were conducted on the northwestern Ross Ice Shelf in Antarctica from November 2010 through January 2011. A significant amount of equipment, supplies, and people safely traversed from McMurdo Station to establish a series of ...
Robert Zook, Frank R. Rack, Richard H. Levy, Richard Limeburner, Craig Stewart, Michael J.M. Williams, Bruce Luyendyk   +6 more
doaj