The optimization method of wing ice shape regulation based on flight dynamics characteristics
Scientific Reports, 2022 Ice on aircraft wing changes the aircraft aerodynamic shape, and has negative effects on flight dynamic characteristics, seriously threatening flight safety. Plasma ice shape regulation is a new de-icing method.
Pengfei Dou +3 more
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Effects of excess ground ice on projections of permafrost in a warming climate
Environmental Research Letters, 2014 In permafrost soils, ‘excess ice’, also referred to as ground ice, exists in amounts exceeding soil porosity in forms such as ice lenses and wedges.
Hanna Lee +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Observing growth and interfacial dynamics of nanocrystalline ice in thin amorphous ice films
Nature CommunicationsIn-situ cryo-electron microscopy in thin amorphous ice films and ice-dynamics simulations reveal polymorph-dependent growth kinetics of nanoscale ice crystals.
Minyoung Lee +7 more
semanticscholar +1 more source
The Influence of Hydrology on the Dynamics of Land-Terminating Sectors of the Greenland Ice Sheet
Frontiers in Earth Science, 2019 Coupling between runoff, hydrology, basal motion, and mass loss (“hydrology-dynamics”) is a critical component of the Greenland Ice Sheet system. Despite considerable research effort, the mechanisms by which runoff influences ice dynamics and the net ...
B. Davison +4 more
semanticscholar +1 more source
The Many Faces of Heterogeneous Ice Nucleation: Interplay Between Surface Morphology and Hydrophobicity [PDF]
, 2015 What makes a material a good ice nucleating agent? Despite the importance of heterogeneous ice nucleation to a variety of fields, from cloud science to microbiology, major gaps in our understanding of this ubiquitous process still prevent us from ...
Cox, Stephen J +3 more
core +3 more sources
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Review article: Melt-affected ice cores for polar research in a warming world [PDF]
The CryosphereMelting polar and alpine ice sheets in response to global warming pose ecological and societal risks but will also hamper our ability to reconstruct past climate and atmospheric composition across the globe. Since polar ice caps are crucial environmental
D. E. Moser +7 more
doaj +1 more source