Results 71 to 80 of about 183,990 (318)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Retrieval of Cloud Macro‐Physical Properties Using theFY‐4A Advanced Geostationary Radiation Imager (AGRI) and the Geostationary Interferometric Infrared Sounder (GIIRS)

Geophysical Research Letters
This study presents a novel approach for conducting all‐day retrieval of cloud macro‐physical properties (single‐layer cloud phase, cloud top height, and cloud base height for optical thickness less than 10) using the Advanced Geostationary Radiation ...
Bin Guo, Feng Zhang, Zhijun Zhao, Jinyu Guo, Wenwen Li   +4 more
doaj   +1 more source

ATP13A2 is involved in intracellular polyamine transport in lung epithelial cells

FEBS Open Bio, EarlyView.
Spermidine transport in lung epithelial cells involves the polyamine transporter ATP13A2. Cell proliferation is associated with the upregulation of ATP13A2. Polyamines are present in all living cells and are implicated in various crucial cellular processes such as proliferation, apoptosis and autophagy.
Yuta Hatori, Kohei Kawabata, Takanori Kubo, Takeo Kitazawa, Sae Kanai, Madoka Iwashita, Ami Hayashi, Hiroyuki Nishi, Mikihisa Takano   +8 more
wiley   +1 more source

Thermodynamic effect dictates influence of the Atlantic Multidecadal Oscillation on Eurasia winter temperature

npj Climate and Atmospheric Science
The Atlantic Multidecadal Oscillation (AMO) has garnered attention for its important role in shaping surface air temperature (SAT) patterns over Eurasia.
Huan Wang, Zhiyan Zuo, Renhe Zhang, Li Peng, Kaiwen Zhang, Deliang Chen, Dong Xiao, Qinglong You, Guokun Dai, Ruonan Zhang, Haijun Yang, Xiaodan Chen, Zouxing Lin, Peiqiang Xu, Liang Qiao   +14 more
doaj   +1 more source

Treatment of the ice-shelf backpressure and buttressing in two horizontal dimensions

Journal of Glaciology
The ice discharge from the grounded parts of marine ice sheets into the ocean is modulated by their floating extensions – ice shelves. The ice-shelf impact on the grounded ice is typically described as ‘backpressure’ or ‘buttressing’.
Olga Sergienko
doaj   +1 more source

Inferring geothermal heat flux from an ice-borehole temperature profile at Law Dome, East Antarctica

Journal of Glaciology, 2020
Geothermal heat flux (GHF) is an important control on the dynamics of Antarctica's ice sheet because it controls basal melt and internal deformation. However, it is hard to estimate because of a lack of in-situ measurements.
Laura Mony, Jason L. Roberts, Jacqueline A. Halpin   +2 more
doaj   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Environmental record of layers of bubbles in natural pond ice

Journal of Glaciology, 2018
Autonomous temperature data loggers were used to measure the temperature profile within a growing ice cover and in the water below. The ice formed under natural conditions over the pond.
JOLANA HRUBA, GUNTHER KLETETSCHKA
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

The significant influence of the Atlantic multidecadal variability to the abrupt warming in Northeast Asia in the 1990s

npj Climate and Atmospheric Science
Northeast Asia experienced unprecedented abrupt warming in the 1990s since the last century. Based on a robust time series and rank frequency evaluation, the Max Planck Institute for Meteorology Grand Ensembles of CMIP5 (MPI-GE5), CMIP6 (MPI-GE6), EC ...
Kaiwen Zhang, Zhiyan Zuo, Laura Suarez-Gutierrez, Lulei Bu   +3 more
doaj   +1 more source