Results 81 to 90 of about 758,566 (299)
Biotechnology and Bioengineering, EarlyView.Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga +2 more
wiley +1 more source
Simulated melt rates for the Totten and Dalton ice shelves [PDF]
Ocean Science, 2014 The Totten Glacier is rapidly losing mass. It has been suggested that this mass loss is driven by changes in oceanic forcing; however, the details of the ice–ocean interaction are unknown.
D. E. Gwyther +3 more
doaj +1 more source
Autonomous Control of Gene Expression Using Endogenous Transcription Signals
Biotechnology and Bioengineering, EarlyView.ABSTRACT Autonomous cell‐based control of heterologous gene expression can simplify batch‐culture bioprocessing by eliminating external monitoring and extrinsic control of culture conditions. Existing approaches use auto‐induction media, synthetic cell‐cell communication systems, or application‐specific biosensors.
Pakpoom Subsoontorn +2 more
wiley +1 more source
Is Vertical Shear in an Ice Shelf Negligible? [PDF]
Journal of Glaciology, 1979 Abstract Vertical shear stress in ice shelves cannot be precisely zero, since the upper and lower surfaces are generally not parallel. By performing stress balance on a vertical column in an ice shelf we calculate what its magnitude must be.
Sanderson, T.J.O., Doake, C.S.M.
openaire +2 more sources
, 2023 Sub-shelf melting is the main driver of current Antarctic mass loss. However, the ocean processesgoverning ice shelf melting are not well understood and sub-shelf melt is currently themain uncertainty source within Antarctic sea level projections ...
Zipf, Lars +2 more
core
BMEMat, EarlyView.A ROS‐responsive, zwitterionic nanocage enables stable, intranasal siRNA delivery to glioblastoma, promoting deep tumor penetration via non‐degradative pathways and trigeminal nerve transport. This platform achieves durable gene silencing and tumor suppression, offering a non‐invasive, storage‐stable strategy for treating glioma and other neurological ...
Jingwen Xie +12 more
wiley +1 more source
, 2023 The Antarctic ice sheet mass loss is one of the many consequences of Global Warming. This mass loss is primarily driven by ocean warming and the subsequent acceleration of glaciers.
Mathiot, Pierre +3 more
core
Millennial-scale depositional cycles related to British Ice Sheet variability and North Atlantic paleocirculation since 45 kyr B.P., Barra Fan, U.K. margin [PDF]
, 2001 Lithology, lithic petrology, planktonic foraminiferal abundances, and clastic grain sizes have been determined in a 30 m-long core recovered from the Barra Fan off northwest Scotland.
Jones, EJW +6 more
core +1 more source
Biological Reviews, EarlyView.ABSTRACT During their long evolutionary history, land plants have evolved a range of adaptations to different abiotic stressors. These help explain present‐day diversity and distribution patterns, as well as the potential resilience of natural and agricultural systems to a changing climate. Most previous research has focused on adaptation to individual
Marc Fradera‐Soler +6 more
wiley +1 more source
Salinity impact on water flow and lake ice in Lake Vostok, Antarctica [PDF]
, 2003 Lake Vostok, isolated from direct exchange with the atmosphere for million years, provides a unique and so far inaccessible habitat. By using a numerical model, and recent lake geometry information, the lake circulation was investigated for different ...
Mayer, Christoph +7 more
core +1 more source