Results 101 to 110 of about 102,620 (291)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Fracture criteria and tensile strength for natural glacier ice calibrated from remote sensing observations of Antarctic ice shelves

Journal of Glaciology
The conditions under which ice fractures and calves icebergs from Antarctic ice shelves are poorly understood due largely to a lack of relevant observations. Though previous studies have estimated the stresses at which ice fractures in the laboratory and
Sarah Wells-Moran, Meghana Ranganathan, Brent Minchew   +2 more
doaj   +1 more source

Mechanical analysis of pinning points in the Ross Ice Shelf, Antarctica

Annals of Glaciology, 2019
Ice shelves regulate the rate of ice-sheet discharge along much of the Antarctic coastline. Pinning points, sites of localised grounding within floating ice, can in turn, regulate the flow and thickness of an ice shelf.
Holly Still, Adam Campbell, Christina Hulbe   +2 more
doaj   +1 more source

Actively evolving subglacial conduits and eskers initiate ice shelf channels at an Antarctic grounding line [PDF]

, 2017
Ice-shelf channels are long curvilinear tracts of thin ice found on Antarctic ice shelves. Many of them originate near the grounding line, but their formation mechanisms remain poorly understood.
A Jenkins, AM Le Brocq, B Hubbard, CH Dix, CV Gladish, D Callens, DG Vaughan, E Rignot, E Rignot, F Pattyn, FSL Ng, FSL Ng, GH Gudmundsson, H Röthlisberger, HJ Horgan, J Lenaerts, J Walder, JA Dowdeswell, JF Nye, JJ Fürst, K Christianson, K Matsuoka, KE Alley, L Favier, MC Dallaston, MJ Burke, MJ Fried, O Gagliardini, OJ Marsh, OV Sergienko, P Defraigne, P Dutrieux, P Fretwell, PU Clark, R Bindschadler, R Drews, R Drews, RB Alley, RL Hooke, RL Shreve, RS Taylor, RT Walker, RW Jacobel, S Berger, S Fujita, SJ Livingstone, SJ Livingstone, T Cowton, T Millgate, TA Brennand, TP Stanton, TR Davies, TRH Davies, V Helm   +53 more
core   +1 more source

Ensemble of ice shelf basal melt rates and ocean properties for tipped-over continental shelves

, 2021
Verena Haid, Ralph Timmermann, Pierre Mathiot, Nicolas C. Jourdain, Hartmut Hellmer   +4 more
openalex   +1 more source

Characterizing epithelial‐mesenchymal transition‐linked heterogeneity in breast cancer circulating tumor cells at a single‐cell level

Molecular Oncology, EarlyView.
In over 50% of non‐metastatic breast cancer patients, circulating tumor cells (CTCs) along the whole epithelial‐mesenchymal transition spectrum are detected. Total CTC number and individual phenotypes relate to aggressive disease characteristics, including lymph node involvement and higher tumor proliferation. At the single‐cell level, mesenchymal CTCs
Justyna Topa, Julia Richert, Tomasz Stokowy, Alicja Staśczak, Mariusz Szajewski, Maciej Ciesielski, Petra M. Grešner, Bartłomiej Tomasik, Łukasz Arcimowicz, Agnieszka Stankiewicz, Grażyna Suchodolska, Elżbieta Senkus, Wiesław Kruszewski, Anna J. Żaczek, Aleksandra Markiewicz   +14 more
wiley   +1 more source

The long-term and interannual variability of summer fresh water storage over the eastern Siberian shelf: Implication for climatic change [PDF]

, 2008
A time series of summer fresh water content anomalies (FWCA) over the Laptev and East Siberian sea shelves was constructed from historical hydrographic records for the period from 1920 to 2005.
Aagaard, Aagaard, Bitz, Climatic Atlas of the Arctic Seas 2004: Part I. Database Barents, Kara, Laptev, and White Seas–Oceanography and Marine Biology, Comiso, Comiso, Conkright, Dmitrenko, Guay, Harms, Häkkinen, Igor A. Dmitrenko, Johnson, L. Bruno Tremblay, Laxon, Makshtas, Münchow, Peterson, Peterson, Polyakov, Polyakov, Polyakov, Rigor, Rudels, Sergey A. Kirillov, Serreze, Shpaikher, Simstich, Steele, Steiner, Stroeve, Swift, Walsh, Yang   +33 more
core   +1 more source

Factors driving Supraglacial Lake variability on ice shelves in Dronning Maud Land, East Antarctica

, 2023
Anirudha Mahagaonkar, Geir Moholdt, Thomas V. Schuler   +2 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source