Results 101 to 110 of about 588,382 (370)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Antarctic ice sheet response to sudden and sustained ice-shelf collapse (ABUMIP)

Journal of Glaciology, 2020
Antarctica's ice shelves modulate the grounded ice flow, and weakening of ice shelves due to climate forcing will decrease their ‘buttressing’ effect, causing a response in the grounded ice.
Sainan Sun, Frank Pattyn, Erika G. Simon, Torsten Albrecht, Stephen Cornford, Reinhard Calov, Christophe Dumas, Fabien Gillet-Chaulet, Heiko Goelzer, Nicholas R. Golledge, Ralf Greve, Matthew J. Hoffman, Angelika Humbert, Elise Kazmierczak, Thomas Kleiner, Gunter R. Leguy, William H. Lipscomb, Daniel Martin, Mathieu Morlighem, Sophie Nowicki, David Pollard, Stephen Price, Aurélien Quiquet, Hélène Seroussi, Tanja Schlemm, Johannes Sutter, Roderik S. W. van de Wal, Ricarda Winkelmann, Tong Zhang   +28 more
doaj   +1 more source

Quantifying Antarctic‐Wide Ice‐Shelf Surface Melt Volume Using Microwave and Firn Model Data: 1980 to 2021

Geophysical Research Letters, 2023
Antarctic ice‐shelf stability is threatened by surface melt, which has been implicated in several ice‐shelf collapse events over recent decades. Here, we first analyze cumulative days of wet snow/ice status (“melt days”) for melt seasons from 1980 to ...
Alison F. Banwell, Nander Wever, Devon Dunmire, Ghislain Picard   +3 more
doaj   +1 more source

Blocking a wave: Frequency band gaps in ice shelves with periodic crevasses [PDF]

, 2011
We assess how the propagation of high-frequency elastic-flexural waves through an ice shelf is modified by the presence of spatially periodic crevasses.
Ashcroft, Chou, Douglas R. MacAyeal, Jason M. Amundson, Julian Freed-Brown, Landau, Sheng, Van der Veen, Van der Veen, Wendy W. Zhang   +9 more
core   +2 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Representation of sharp rifts and faults mechanics in modeling ice shelf flow dynamics: Application to Brunt/Stancomb-Wills Ice Shelf, Antarctica [PDF]

, 2014
Ice shelves play a major role in buttressing ice sheet flow into the ocean, hence the importance of accurate numerical modeling of their stress regime. Commonly used ice flow models assume a continuous medium and are therefore complicated by the presence
Borstad, C. P., Khazendar, A., Larour, E., Morlighem, M., Rignot, E., Seroussi, H.   +5 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Vulnerable Antarctic ice shelves

Nature Climate Change, 2016
Standfirst: The decay of floating ice shelves around Antarctica speeds up ice flow from the continent and enhances sea-level rise. Now meltwater attributed to warm winds has been discovered on an East Antarctic ice shelf, suggesting greater vulnerability than previously thought.
openaire   +3 more sources

Basal channels on ice shelves [PDF]

Journal of Geophysical Research: Earth Surface, 2013
Recent surveys of floating ice shelves associated with Pine Island Glacier (Antarctica) and Petermann Glacier (Greenland) indicate that there are channels incised upward into their bottoms that may serve as the conduits of meltwater outflow from the sub‐ice‐shelf cavity.
openaire   +1 more source

Marine Ice Cliff Instability Mitigated by Slow Removal of Ice Shelves

Geophysical Research Letters, 2019
The accelerated calving of ice shelves buttressing the Antarctic Ice Sheet may form unstable ice cliffs. The marine ice cliff instability hypothesis posits that cliffs taller than a critical height (~90 m) will undergo structural collapse, initiating ...
F. Clerc, B. Minchew, M. Behn
semanticscholar   +1 more source