Results 31 to 40 of about 87,892 (246)

NMR characterizations of the ice binding surface of an antifreeze protein. [PDF]

PLoS ONE, 2010
Antifreeze protein (AFP) has a unique function of reducing solution freezing temperature to protect organisms from ice damage. However, its functional mechanism is not well understood.
Jiang Hong, Yunfei Hu, Congmin Li, Zongchao Jia, Bin Xia, Changwen Jin   +5 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The Fate of Frozen Carbonated Water at Europa-like Conditions

The Planetary Science Journal
We present the results of experiments probing the retention of CO _2 in crystalline water ice, frozen sodium chloride (NaCl) brines, and flash-frozen carbonated water using diffuse reflectance infrared spectroscopy. Characteristic absorptions alluding to
Swaroop Chandra, William T. P. Denman, Michael E. Brown   +2 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

CO2 Infrared Spectra on Silicate Dust Grain Analogs: Implications for JWST Observations

The Astrophysical Journal Letters
Carbon dioxide is one of the three most abundant species within the ice mantles around dust grains inside molecular clouds. Since a substantial number of interstellar grains are made of siliceous materials, we have studied the infrared profile of CO _2 ...
Tushar Suhasaria, Vanessa Leuschner, Cornelia Jäger, Caroline Gieser, Thomas Henning   +4 more
doaj   +1 more source

Single particle ICP-TOFMS on previously characterised EGRIP ice core samples: new approaches, limitations, and challenges [PDF]

The Cryosphere
Polar ice contains chemical impurities, which can be used as a proxy for the past climate, using state-of-the-art chemical methods. Despite its capability to access critical physicochemical parameters of insoluble particles, such as number concentration,
N. Stoll, N. Stoll, D. Clases, R. Gonzalez de Vega, M. Elinkmann, P. Larkman, P. Larkman, P. Bohleber, P. Bohleber, P. Bohleber   +9 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Neutron spectroscopy of high-density amorphous ice [PDF]

Physica B: Condensed Matter, 1999
Abstract Vibrational spectra of high-density amorphous ice (hda-ice) for H 2 O and D 2 O samples were measured by inelastic neutron scattering. The measured spectra of hda-ice are closer to those for high-pressure phase ice-VI, but not for low-density ice-Ih.
A.I Kolesnikov, J.C Li, N.C Ahmad, C.-K Loong, J Nipko, D Yocum, S.F Parker   +6 more
openaire   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Enhancing Icephobic Coatings: Exploring the Potential of Dopamine-Modified Epoxy Resin Inspired by Mussel Catechol Groups

Biomimetics
A nature-inspired approach was employed through the development of dopamine-modified epoxy coating for anti-icing applications. The strong affinity of dopamine’s catechol groups for hydrogen bonding with water molecules at the ice/coating interface was ...
Mohammad Sadegh Koochaki, Gelareh Momen, Serge Lavoie, Reza Jafari   +3 more
doaj   +1 more source