Results 51 to 60 of about 260,636 (325)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

CO2 Infrared Spectra on Silicate Dust Grain Analogs: Implications for JWST Observations

The Astrophysical Journal Letters
Carbon dioxide is one of the three most abundant species within the ice mantles around dust grains inside molecular clouds. Since a substantial number of interstellar grains are made of siliceous materials, we have studied the infrared profile of CO _2 ...
Tushar Suhasaria, Vanessa Leuschner, Cornelia Jäger, Caroline Gieser, Thomas Henning   +4 more
doaj   +1 more source

Single particle ICP-TOFMS on previously characterised EGRIP ice core samples: new approaches, limitations, and challenges [PDF]

The Cryosphere
Polar ice contains chemical impurities, which can be used as a proxy for the past climate, using state-of-the-art chemical methods. Despite its capability to access critical physicochemical parameters of insoluble particles, such as number concentration,
N. Stoll, N. Stoll, D. Clases, R. Gonzalez de Vega, M. Elinkmann, P. Larkman, P. Larkman, P. Bohleber, P. Bohleber, P. Bohleber   +9 more
doaj   +1 more source

Boron Nitride Nanomesh: A template for Nano-ice

, 2009
Using variable temperature scanning tunneling microscopy and dI/dz barrier height spectroscopy, the structure of water on h-BN/Rh(111) nanomesh has been investigated. Below its desorption temperature, two distinct phases of water self-assemble within the
Berner, Bunk, Corso, de Vries, Dil, Doering, Goedecker, Grimme, Henderson, Laskowski, Lippert, Mehlhorn, Michaelides, Mitsui, Ogasawara, Olsson, Perdew, Pivetta, Qi, Shimizu, Thiel, Widmer   +21 more
core   +2 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Modelling light scattering by absorbing smooth and slightly rough facetted particles [PDF]

, 2015
A method for approximating light scattering properties of strongly absorbing facetted particles which are large compared to the wavelength is presented.
Collier, C. T., Hesse, Evelyn, Kaye, Paul H., Nousiainen, Timo, Penttilä, Antti, Ulanowski, Joseph   +5 more
core   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Enhancing Icephobic Coatings: Exploring the Potential of Dopamine-Modified Epoxy Resin Inspired by Mussel Catechol Groups

Biomimetics
A nature-inspired approach was employed through the development of dopamine-modified epoxy coating for anti-icing applications. The strong affinity of dopamine’s catechol groups for hydrogen bonding with water molecules at the ice/coating interface was ...
Mohammad Sadegh Koochaki, Gelareh Momen, Serge Lavoie, Reza Jafari   +3 more
doaj   +1 more source

Characterization of individual ice residual particles by the single droplet freezing method: a case study in the Asian dust outflow region [PDF]

Atmospheric Chemistry and Physics, 2018
In order to better characterize ice nucleating (IN) aerosol particles in the atmosphere, we investigated the chemical composition, mixing state, and morphology of atmospheric aerosols that nucleate ice under conditions relevant for mixed-phase clouds.
A. Iwata, A. Matsuki
doaj   +1 more source

The Use of Ultrasound in Shaping the Properties of Ice Cream with Oleogel Based on Oil Extracted from Tomato Seeds

Applied Sciences, 2022
In this study, the possibility of using ultrasound technology as an alternative to traditional pasteurization and homogenization in ice cream production was presented. Three types of ice cream with different proportions of oleogel (5, 6, and 7%) prepared
Sybilla Nazarewicz, Katarzyna Kozłowicz, Zbigniew Kobus, Bożena Gładyszewska, Arkadiusz Matwijczuk, Lidia Ślusarczyk, Tomasz Skrzypek, Monika Sujka, Natalia Kozłowicz   +8 more
doaj   +1 more source