Results 51 to 60 of about 445,645 (282)

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Influence of Ice Growth Mode on the Ice Thickness and Shape Prediction of Two-Dimensional Airfoil

Aerospace
Computational results of aircraft icing and predictions of ice shape are not only determined by the solutions of air-supercooled droplet two-phase flow and icing thermodynamic models of surface water film, but are also influenced by the growth mode of ...
Xiaobin Shen, Jingyu Zhao, Zekun Ye, Huanfa Wang, Guiping Lin   +4 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Monitoring Sea Ice Thickness Using GNSS-Interferometric Reflectometry

IEEE Geoscience and Remote Sensing Letters, 2022
Abstract This letter presents the analysis of frozen sea surface properties using low-cost and low-complexity terrestrial global navigation satellite system (GNSS) receivers. Monitoring sea ice thickness and the mean sea level (MSL) of the frozen sea are performed using the interference frequency obtained by the GNSS interference pattern (IP) technique.
Ankit Regmi, Marko E. Leinonen, Aarno Parssinen, Markus Berg   +3 more
openaire   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Arctic sea ice variation in the Northwest Passage in 1979–2017 and its response to surface thermodynamics factors

Advances in Climate Change Research, 2021
Sea ice conditions in the Canadian Arctic Archipelago (CAA) play a key role in the navigation of the Northwest Passage (NWP). Limited by observed sea ice thickness data, the research of temporal and spatial variation of sea ice in the NWP is insufficient.
Xin-Yi Shen, Yu Zhang, Chang-Sheng Chen, Song Hu, Dan-Ya Xu, Wei-Zeng Shao, Liang Chang, Gui-Ping Feng   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Spatiotemporal Analysis and Modeling of Sea Ice Growth Rate in Nella Fjord, Antarctica: Based on Observations During the 36th Chinese National Antarctic Research Expedition in 2020

Frontiers in Environmental Science, 2022
Obtaining field sea ice data is crucial for the validation and improvement of satellite data and numerical models. During the 36th Chinese National Antarctic Research Expedition, seven field observations covering the whole area were conducted in Nella ...
Xiaoyu Sun, Yawen He, Tingting Lv, Chunhua Li, Yi Gao, Fu Zhao, Zhenshan Xue   +6 more
doaj   +1 more source

On the errors involved in ice-thickness estimates II: errors in digital elevation models of ice thickness [PDF]

Journal of Glaciology, 2016
ABSTRACTThis paper is the second (Paper II) in a set of studies concerning the errors involved in the estimate of ice thickness and ice volume. Here we present a detailed analysis of the errors involved in the generation of ice-thickness DEMs constructed, most often, from GPR data, complemented by boundary data and sometimes, additional synthetic data ...
Lapazaran, J. J., Otero, J., Martín-Español, A., Navarro, F. J.   +3 more
openaire   +4 more sources