Results 31 to 40 of about 117,111 (323)

Greenhouse gas observation network design for Africa

Tellus: Series B, Chemical and Physical Meteorology, 2020
An optimal network design was carried out to prioritise the installation or refurbishment of greenhouse gas (GHG) monitoring stations around Africa. The network was optimised to reduce the uncertainty in emissions across three of the most important GHGs:
Alecia Nickless, Robert J. Scholes, Alex Vermeulen, Johannes Beck, Ana López-Ballesteros, Jonas Ardö, Ute Karstens, Matthew Rigby, Ville Kasurinen, Karolina Pantazatou, Veronika Jorch, Werner Kutsch   +11 more
doaj   +1 more source

ICOSL Stimulation by ICOS-Fc Accelerates Cutaneous Wound Healing In Vivo

International Journal of Molecular Sciences, 2022
Background: ICOS and its ligand ICOSL are immune receptors whose interaction triggers bidirectional signals that modulate the immune response and tissue repair.
I. Stoppa, C. L. Gigliotti, N. Clemente, Deepika Pantham, C. Dianzani, Chiara Monge, C. Puricelli, R. Rolla, S. Sutti, F. Renó, R. Boldorini, E. Boggio, U. Dianzani   +12 more
semanticscholar   +1 more source

Vaccination with a shared oncogenic tumor-self antigen elicits a population of CD8+ T cells with a regulatory phenotype

Human Vaccines & Immunotherapeutics, 2022
Cancer immunotherapy is a powerful tool for inducing antigen-specific antitumor cytotoxic T lymphocytes (CTLs). Next-generation strategies may include vaccination against overexpressed oncogenic tumor-self antigens.
C. Riccay Elizondo, Jennifer D. Bright, Robert K. Bright   +2 more
doaj   +1 more source

Validation of the Harvard Lyman-α in situ water vapor instrument: Implications for the mechanisms that control stratospheric water vapor [PDF]

, 2009
Building on previously published details of the laboratory calibrations of the Harvard Lyman-α photofragment fluorescence hygrometer (HWV) on the NASA ER-2 and WB-57 aircraft, we describe here the validation process for HWV, which includes laboratory ...
Anderson, J. G., Hanisco, T. F., Hintsa, E. J., Moyer, E. J., Pittman, J. V., Sargent, M. R., Sayres, D. S., Smith, J. B., Spackman, J. R., St. Clair, J. M., Weinstock, E. M.   +10 more
core   +1 more source

Expression of TIM3/VISTA checkpoints and the CD68 macrophage-associated marker correlates with anti-PD1/PDL1 resistance: implications of immunogram heterogeneity. [PDF]

, 2020
Although immunotherapies have achieved remarkable salutary effects among subgroups of advanced cancers, most patients do not respond. We comprehensively evaluated biomarkers associated with the "cancer-immunity cycle" in the pan-cancer setting in order ...
Dressman, Devin, Eskander, Ramez, Glenn, Sean T, Goodman, Aaron, Ikeda, Sadakatsu, Kato, Shumei, Kumaki, Yuichi, Kurzrock, Razelle, Lee, Suzanna, Lenzo, Felicia L, Morrison, Carl, Nikanjam, Mina, Okamura, Ryosuke, Papanicolau-Sengos, Antonios   +13 more
core   +1 more source

IFNAR1-Signalling Obstructs ICOS-mediated Humoral Immunity during Non-lethal Blood-Stage Plasmodium Infection [PDF]

, 2016
Funding: This work was funded by a Career Development Fellowship (1028634) and a project grant (GRNT1028641) awarded to AHa by the Australian National Health & Medical Research Council (NHMRC).
A Haque, A Haque, A Haque, A Le Bon, A Pratama, A Pratama, A Sabchareon, AJ McAdam, Andreas Hutloff, Ashraful Haque, BC Rocha, Bryce S. Thomas, C Aucan, C Li, C Shin, C Voisine, CC Kim, CG Matar, Christian R. Engwerda, CL Edwards, D Baumjohann, D Liu, D Perez-Mazliah, D Yu, DJ Wikenheiser, DK Raj, DS Karunarathne, DS Khoury, EA Ball, EG Findlay, ES Coro, Fabian de Labastida Rivera, Fernando Souza-Fonseca-Guimaraes, FH Amante, FH Amante, Fiona H. Amante, G Jego, G Suss, G Trinchieri, Geoffrey R. Hill, H Akiba, H Cucak, H Ueno, H Veiga-Fernandes, H Xu, HC van der Heyde, Ismail Sebina, J Banchereau, J Langhorne, J Li, JA Harker, JA Harker, JC Hall, JL Grun, JP Ray, JP Weber, JW Leavenworth, K Warnatz, Kylie R. James, L Beattie, LB Ivashkiv, Lily G. Fogg, Lynette Beattie, Marcela Montes de Oca, Marcela Montes de Oca, Maria M. Mota, Mark J. Smyth, Megan S. F. Soon, MJ Boyle, MT White, N Obeng-Adjei, NS Butler, O Dienz, Paul J. Hertzog, PF Yong, RA Seder, RA Zander, S Cohen, S Crotty, S Nakayamada, S Pichyangkul, S Portugal, S Sharma, Shannon E. Best, T von der Weid, V Ryg-Cornejo, YS Choi, YS Choi, YS Choi, Z Su   +89 more
core   +5 more sources

Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma

Annals of the Rheumatic Diseases, 2020
Objectives To explore the relevance of T-follicular-helper (Tfh) and pathogenic peripheral-helper T-cells (Tph) in promoting ectopic lymphoid structures (ELS) and B-cell mucosa-associated lymphoid tissue (MALT) lymphomas (MALT-L) in Sjögren’s syndrome ...
E. Pontarini, W. Murray-Brown, C. Croia, D. Lucchesi, James Conway, F. Rivellese, L. Fossati-Jimack, E. Astorri, E. Prediletto, E. Corsiero, Francesca Romana Delvecchio, R. Coleby, Eva Gelbhardt, Aurora Bono, C. Baldini, I. Puxeddu, P. Ruscitti, R. Giacomelli, F. Barone, B. Fisher, S. Bowman, S. Colafrancesco, R. Priori, N. Sutcliffe, S. Challacombe, G. Carlesso, A. Tappuni, C. Pitzalis, M. Bombardieri   +28 more
semanticscholar   +1 more source

ICOS controls Foxp3+ regulatory T-cell expansion, maintenance, and IL-10 production during helminth infection [PDF]

, 2012
Foxp3(+) regulatory T (Treg) cells are key immune regulators during helminth infections, and identifying the mechanisms governing their induction is of principal importance for the design of treatments for helminth infections, allergies and autoimmunity.
Cervera, Ana, Gray, David, MacDonald, Andrew, Maizels, Rick, Redpath, Stephen A, Taylor, Matthew, van der Werf, Nienke   +6 more
core   +1 more source

Trial Watch: Immunostimulatory monoclonal antibodies for oncological indications

OncoImmunology, 2017
The goal of cancer immunotherapy is to establish new or boost pre-existing anticancer immune responses that eradicate malignant cells while generating immunological memory to prevent disease relapse.
Mariona Cabo, Rienk Offringa, Laurence Zitvogel, Guido Kroemer, Aura Muntasell, Lorenzo Galluzzi   +5 more
doaj   +1 more source

Increased Levels of ICOS and ICOSL Are Associated to Pulmonary Arterial Hypertension in Patients Affected by Connective Tissue Diseases

Diagnostics, 2022
Background: Pulmonary hypertension (PH) is a life-threatening complication of connective tissue diseases (CTD); in this study, we aimed at investigating the potential role of inducible co-stimulator (ICOS) and its ligand (ICOS-L) as biomarkers of PH in ...
Mattia Bellan, Francesco Murano, Federico Ceruti, Cristina Piccinino, Stelvio Tonello, Rosalba Minisini, Ailia Giubertoni, Daniele Sola, Roberta Pedrazzoli, Veronica Maglione, Giulia Francesca Manfredi, Antonio Acquaviva, Roberto Piffero, Giuseppe Patti, Mario Pirisi, Pier Paolo Sainaghi   +15 more
doaj   +1 more source