Results 71 to 80 of about 117,111 (323)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

CD27 and ICOS as Targets of PD-1/PD-L1 Signaling to Regulate Resident Memory CD8⁺ T-Cell-Mediated Pulmonary Protection and Pathology. [PDF]

Adv Sci (Weinh)
Here it is revealed that the costimulatory receptors CD27 and ICOS are essential for the long‐term maintenance of PD‐1high CD8+ TRM cells following influenza infection. PD‐L1 blockade enhances the proliferation and activation of these cells through Nur77 activation downstream of the CD27/ICOS signaling axis, thereby boosting host immunity against ...
Chen Y, Wang Z, Song L, Chen Q, Zhang H, Pan T, Pan J, Zhao S, Shang T, Xu H, Lv X, Li J, Kang F, Nie Y, Zhao F, Shi L, Wang Z.   +16 more
europepmc   +2 more sources

The role of contracting strategies in social value implementation [PDF]

, 2015
There has been an increasing demand for social value (SV) implementation to assume a cardinal position in the infrastructure delivery efforts of infrastructure client organisations (ICOs).
Awuzie BO, Awuzie BO, Balouga J, Bankole O. Awuzie, Carmichael DG, Denscombe M, Dickinson M, Dorée A, DPER (Department of Public Expenditure and Reform), Eisenhardt KM, Emmitt S, Esteves AM, Esteves AM, Hartley J, Hill M, IUK (Infrastructure UK), McDermott P, Miles MB, Mulgan G, Peter McDermott, Public Services (Social Value) Act 2012, Rowlinson S, Russell S, Schramm C, Snieska V, Tawiah PA, Taylor-Powell E, Walker D, Warner M, Watermeyer RB, Watermeyer RB, Wells J, Wood C, Yin RK   +33 more
core   +3 more sources

Molecular Imaging of Chimeric Antigen Receptor T Cells by ICOS-ImmunoPET

Clinical Cancer Research, 2020
Purpose: Immunomonitoring of chimeric antigen receptor (CAR) T cells relies primarily on their quantification in the peripheral blood, which inadequately quantifies their biodistribution and activation status in the tissues. Noninvasive molecular imaging
F. Simonetta, Israt S. Alam, J. Lohmeyer, B. Sahaf, Zinaida Good, Weiyu Chen, Zunyu Xiao, Toshihito Hirai, L. Scheller, Pujan Engels, O. Vermesh, Elise R. Robinson, Tom Haywood, Ataya Sathirachinda, J. Baker, Meena B. Malipatlolla, Liora M. Schultz, J. Spiegel, Jason T. Lee, D. Miklos, C. Mackall, S. Gambhir, R. Negrin   +22 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A novel combination of chemotherapy and immunotherapy controls tumor growth in mice with a human immune system

OncoImmunology, 2019
Mice reconstituted with a human immune system and bearing human tumors represent a promising model for developing novel cancer immunotherapies. Here, we used mass cytometry and multi-parametric flow cytometry to characterize human leukocytes infiltrating
Aude Burlion, Rodrigo N. Ramos, Pukar KC, Kélhia Sendeyo, Aurélien Corneau, Christine Ménétrier-Caux, Eliane Piaggio, Daniel Olive, Christophe Caux, Gilles Marodon   +9 more
doaj   +1 more source

T cell receptor signaling defines the fate and pathway of ICOS internalization

Biochemistry and Biophysics Reports, 2020
The role of the inducible costimulatory of T cells (ICOS) has been shown to be important for many different T cell outcomes and is indispensable for follicular helper T cell (TFH) responses.
Joseph C. Lownik, Daniel H. Conrad, Rebecca K. Martin   +2 more
doaj   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Note on the compatibility of ICOS, NEON, and TERN sampling designs, different camera setups for effective plant area index estimation with digital hemispherical photography

Metsanduslikud Uurimused
Environmental monitoring networks such as the Integrated Carbon Observation System (ICOS) in Europe, the National Ecological Observatory Network (NEON) in the U.S., or the Terrestrial Ecosystem Research Network (TERN) in Australia deploy different ...
Kaha Mihkel, Lang Mait, Zhang Shaohui, Pisek Jan   +3 more
doaj   +1 more source

Inducible costimulator expression regulates the magnitude of Th2-mediated airway inflammation by regulating the number of Th2 cells. [PDF]

PLoS ONE, 2009
Inducible Costimulator (ICOS) is an important regulator of Th2 lymphocyte function and a potential immunotherapeutic target for allergy and asthma. A SNP in the ICOS 5' promoter in humans is associated with increased atopy and serum IgE in a founder ...
Bryan S Clay, Rebecca A Shilling, Hozefa S Bandukwala, Tamson V Moore, Judy L Cannon, Andrew A Welcher, Joel V Weinstock, Anne I Sperling   +7 more
doaj   +1 more source