Results 71 to 80 of about 2,243,337 (343)
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Universal quantum computation with ideal Clifford gates and noisy ancillas (14 pages) [PDF]
, 2004 We consider a model of quantum computation in which the set of elementary operations is limited to Clifford unitaries, the creation of the state |0>, and qubit measurement in the computational basis.
S. Bravyi, A. Kitaev
semanticscholar +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Addressing the Relationship between Power, State and Society in Pre-Modern Iran [PDF]
دولتپژوهی, 2019 This article, using the method of historical sociology and the sociology of knowledge, attempts to address the power relations between society and government in Iran before the emergence of the Pahlavi state.
Mahdi Abbasi Shahkooh
doaj +1 more source
Molecular Oncology, EarlyView.C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald +18 more
wiley +1 more source
ISLAM, HAK DAN KESEHATAN REPRODUKSI
Komunika, 2015 Islam is often preceived as a religion that give lack attention to the rights of reproduction for women. Islam is considered as religion that views reproduction as women’s duty and never views women’s rights in relation to reproduction.
Waliko Waliko
doaj +1 more source
Compositio Mathematica, 2004 20 pages, to appear in Compositio ...
Craig Huneke, Ngo Viet Trung
openaire +4 more sources
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Twenty-eight new and significant departmental reptile records for Paraguay
Acta Zoológica LilloanaTwenty-eight new distribution records are reported for twenty-seven species of Paraguayan reptiles. Ten of these species are considered threatened at the national level (6 EN, 2 VU, 2 DD).
Paul Smith +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source