Results 81 to 90 of about 1,820,264 (313)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

What is an attractive body? Using an interactive 3D program to create the ideal body for you and your partner

, 2012
What is the ideal body size and shape that we want for ourselves and our partners? What are the important physical features in this ideal? And do both genders agree on what is an attractive body?
Martin J. Tovée, Tovée Martin J., Cornelissen, Piers, Piers L Cornelissen, Piers L. Cornelissen, Kara L. Crossley, Crossley Kara L., Martin J Tové, Crossley, Kara, Tovée, Martin, Cornelissen Piers L., Kara L Crossley, Martin J Tovée   +12 more
core   +1 more source

Questioning the Herderian ideal 1

, 2020
This chapter outlines Herder’s philosophy on language and the nation. It attempts to explain how even though the Herderian claim has been a monolingual one, curiously, at the same time, Herder has also been lauded as a trailblazer for promoting ...
Pritipuspa Mishra, Ying-Ying Tan, Tan, Ying Ying, Mishra, Pritipuspa   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Method of Analyzing Complexity by Effects and Rapid Acquisition of the Most Ideal Solution Based on TRIZ [PDF]

, 2009
Organised by: Cranfield UniversityPresently, designers could only use definitions in the complexity theory to analyze the complex problems in the system. In the article, a new method is put forward which is the method of analyzing complexity by effects
Zhang, D. R., Zhang, P., Tan, R. H., Liu, F.   +3 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

El PA denuncia falta de sensibilidad municipal para con los minusválidos

, 1991
El PA denuncia falta de sensibilidad por parte del gobierno municipal de Almería con las personas con diversidad funcional. En apoyo con varias asociaciones, proponen un plan de acción para la eliminación de barreras urbanísticas y arquitectónicas, y ...
Ideal
core  

Differences in male and female athletes and their perceptions of an ideal coach with respect to locus of control, competitiveness, goal-orientation and win-orientation [PDF]

, 2003
Plan BThe current study examined differences between male and female athletes and their perceptions of an ideal coach. The study focused on internal vs.
Johnson, Joshua Spencer
core  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source