Results 101 to 110 of about 7,459,988 (350)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Bistable forespore engulfment in Bacillus subtilis by a zipper mechanism in absence of the cell wall

, 2014
To survive starvation, the bacterium Bacillus subtilis forms durable spores. The initial step of sporulation is asymmetric cell division, leading to a large mother-cell and a small forespore compartment.
Endres, Robert G., López-Garrido, Javier, Ojkic, Nikola, Pogliano, Kit   +3 more
core   +4 more sources

Exigências em treonina para frangos de corte de 22 a 42 dias de idade Threonine requirements of 22 to 42-day-old broilers

Revista Brasileira de Zootecnia, 2012
Um experimento foi realizado com o objetivo de estabelecer critérios de avaliação das exigências de treonina digestível para frangos de corte de 22 a 42 dias de idade utilizando-se diferentes modelos de regressão (quadrático, exponencial e de retas ...
Karina Ferreira Duarte, Otto Mack Junqueira, Rosemeire da Silva Filardi, Jefferson Costa de Siqueira, Edivaldo Antônio Garcia, Antonio Carlos de Laurentiz   +5 more
doaj   +1 more source

Cryo-electron tomography: an ideal method to study membrane-associated proteins [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2017
Cryo-electron tomography (cryo-ET) is a three-dimensional imaging technique that makes it possible to analyse the structure of complex and dynamic biological assemblies in their native conditions. The latest technological and image processing developments demonstrate that it is possible to obtain structural information at nanometre resolution.
Michelle A. Dunstone, Alex de Marco, Alex de Marco   +2 more
openaire   +3 more sources

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Relação lisina digestível: proteína bruta em dietas para frangos de corte no período de 1 a 21 dias de idade. Desempenho e metabolismo Digestible lysine: crude protein ratios on initial broiler diets - performance and metabolism

Revista Brasileira de Zootecnia, 2008
Objetivou-se neste experimento testar diferentes relações lisina digestível:proteína bruta (PB) em dietas para frangos de corte na fase inicial de criação. Utilizou-se um lote misto de 1.800 aves da linhagem Cobb, com um dia de idade.
Kênia Ferreira Rodrigues, Paulo Borges Rodrigues, Rilke Tadeu Fonseca de Freitas, Antonio Gilberto Bertechini, Luiz Fernando Teixeira Albino, Édison José Fassani   +5 more
doaj   +1 more source

Methionine plus cystine requirement, based on ideal protein concept, in diets for Nile tilapia fingerlings

, 2008
Three hundred and ninety six reverted Nile tilapia (Oreochromis niloticus), from Thailand strain, averaging initial weight of 0.86 ± 0.02 g were used to evaluate the effect of feeding methionine plus cystine:lysine levels, based on the ideal protein ...
M. Bomfim, E. A. T. Lanna, J. Donzele, A. S. Ferreira, F. B. Ribeiro, Sylvia Sanae Takishita   +5 more
semanticscholar   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

On Weight Matrix and Free Energy Models for Sequence Motif Detection

, 2010
The problem of motif detection can be formulated as the construction of a discriminant function to separate sequences of a specific pattern from background. In computational biology, motif detection is used to predict DNA binding sites of a transcription
Bailey T.L., Qing Zhou
core   +1 more source

Lysine Requirement Based on Ideal Protein Concept, for Growing Barrows from Two Genetic Groups

, 2001
A trial was carried out to determine the lysine requirements for barrows during growing phase from two genetic pig groups according to the ideal protein concept.
Luiz Fernando Gasparotto, I. Moreira, A. Furlan, E. Martins, Maurício Marcos Júnior   +4 more
semanticscholar   +1 more source