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Protein Microarray: An Ideal Platform for Systems Biology
2012Systems biology intends to understand the biological systems as a whole, it may hold the key for eventually cure of some of the most challenging complex diseases, such as cancer, diabetes, obesity, mental disorders and etc. The major driving forces of systems biology are high-throughput “-omics” technologies, i.e., genomics, transcriptomics, proteomics
Zong-Xiu Wang +4 more
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Analysis of the thermodynamic non-ideality of proteins by sedimentation equilibrium experiments
Biophysical Chemistry, 1999This paper presents a modified method to determine experimentally the second virial coefficient of protein solutions by sedimentation equilibrium experiments. The improvement is based on the possibility of fitting simultaneously up to seven radial concentration distribution curves of solutions with different loading concentrations.
J, Behlke, O, Ristau
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Searching for the Code of Ideal Protein-DNA-Recognition
1987A system is described which allows testing of specific protein-DNA-interactions. The system consists of two mutually compatible plasmids carrying different origins of replication and resistance markers. One plasmid carries a lac I gene in which the DNA-recognizing domain has been replaced by synthetic DNA saturated with restriction sites.
Norbert Lehming +3 more
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Skin: An Ideal Model System to Study Keratin Genes and Proteins
2004Publisher Summary Skin, by virtue of its location at the interface with the outside world, is one of the largest organs in the body that fulfills a number of important functions, undergoes constant renewal, and enjoys significant clinical relevance, as well as social importance. This chapter contains methods that are particularly useful for the basic
Kelsie M, Bernot +2 more
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Effects of thermodynamic non-ideality on protein interactions
2015This thesis involves the examination and description of the effects of thermodynamic non-ideality arising from the space-filling properties of solute species present in the system. Both developmental and applied aspects of nonideality are investigated.Expressions are derived in Chapter 1 for the effects of thermodynamic non-ideality arising from the ...
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Microcrystalline Proteins – An Ideal Benchmark for Methodology Development
2012NMR is one of the most powerful methods for imaging of biomolecules. This book is the ultimate NMR guide for researchers in the biomedical community and gives not only background and practical tips but also a forward looking view on the future of NMR in systems biology.
W. T. Franks +6 more
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