Results 1 to 10 of about 4,882 (214)

Idebenone: When an antioxidant is not an antioxidant

Redox Biology, 2021
Idebenone is a well described drug that was initially developed against dementia. The current literature widely portrays this molecule as a potent antioxidant and CoQ10 analogue.
Nuri Güven, Pranathi Ravishankar, Rajaraman Eri   +2 more
exaly   +6 more sources

Idebenone: Clinical Potential Beyond Neurological Diseases [PDF]

Drug Design, Development and Therapy
Bin Yi,1– 4,* Jun Zeng,1– 4,* Jiashuo Li,1– 4,* Kunfeng Liu,1– 4 Xiaocheng Zhu,4,5 Xiang Chen,4,5 Yang Gao1– 4 1Department of Thoracic Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, People’s Republic of ...
Yi B, Zeng J, Li J, Liu K, Zhu X, Chen X, Gao Y   +6 more
doaj   +4 more sources

Idebenone Mitigates Traumatic-Brain-Injury-Triggered Gene Expression Changes to Ephrin-A and Dopamine Signaling Pathways While Increasing Microglial Genes [PDF]

Cells
Traumatic brain injury (TBI) leads to persistent pro-inflammatory microglial activation implicated in neurodegeneration. Idebenone, a coenzyme Q10 analogue that interacts with both mitochondria and the tyrosine kinase adaptor SHC1, inhibits aspects of ...
Hyehyun Hwang, Chinmoy Sarkar, Boris Piskoun, Naibo Zhang, Apurva Borcar, Courtney L. Robertson, Marta M. Lipinski, Nagendra Yadava, Molly J. Goodfellow, Brian M. Polster   +9 more
doaj   +2 more sources

Idebenone Alleviates Neuroinflammation and Modulates Microglial Polarization in LPS-Stimulated BV2 Cells and MPTP-Induced Parkinson’s Disease Mice

Frontiers in Cellular Neuroscience, 2019
Background: Idebenone is an antioxidant and a coenzyme Q10 analog that has been used to treat neurodegeneration disease. Some studies show idebenone exerts anti-inflammatory effects.
Zhihua Liu, Na Wu
exaly   +3 more sources

Comparative Antioxidant Protection of Cochlear Hair Cells from Ototoxins [PDF]

Molecules
Many forms of damage to cochlear sensory cells involve reactive oxygen species (ROS). We previously screened 81 antioxidants in vitro for the ability to reduce cochlear hair cell (HC) damage by the ototoxic aminoglycoside gentamicin. Only 13 antioxidants
Allen F. Ryan, Kwang Pak, Eun Jung Lee, Arwa Kurabi   +3 more
doaj   +2 more sources

Idebenone increases mitochondrial complex I activity in fibroblasts from LHON patients while producing contradictory effects on respiration [PDF]

BMC Research Notes, 2011
Background Leber's hereditary optic neuropathy (LHON) is caused by mutations in the complex I subunits of the respiratory chain. Although patients have been treated with idebenone since 1992, the efficacy of the drug is still a matter of debate.
Angebault Claire, Gueguen Naïg, Desquiret-Dumas Valérie, Chevrollier Arnaud, Guillet Virginie, Verny Christophe, Cassereau Julien, Ferre Marc, Milea Dan, Amati-Bonneau Patrizia, Bonneau Dominique, Procaccio Vincent, Reynier Pascal, Loiseau Dominique   +13 more
doaj   +7 more sources

Idebenone vs. rAAV2-ND4 gene therapy in the treatment of Leber’s hereditary optic neuropathy: An indirect comparison meta-analysis [PDF]

Indian Journal of Ophthalmology
To compare the outcomes between idebenone oral therapy and rAAV2-ND4 intravitreal injection in the treatment of Leber’s hereditary optic neuropathy. A systematic literature review was performed of publications from 1990 to 2023 in PubMed, Ovid MEDLINE ...
Amr K Hassan, Hashem Abu Serhan
doaj   +2 more sources

IT TAKES TWO TO TANGO: potential novel therapies for autosomal dominant optic atrophy [PDF]

Frontiers in Ophthalmology
Autosomal dominant optic atrophy (ADOA) is among the most prevalent inherited optic neuropathies with hallmark symptoms of bilateral, painless, progressive, and typically permanent vision loss over time.
Ritu Sampige, Lyra E.A. Seaborn, Molly Pluenneke, Annika Jyothi, Sophie Saland, Chisom M. Chinedu-Obi, Caroline Keehn, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee, Andrew G. Lee   +14 more
doaj   +2 more sources

Cytoprotective Effect of Idebenone through Modulation of the Intrinsic Mitochondrial Pathway of Apoptosis in Human Retinal Pigment Epithelial Cells Exposed to Oxidative Stress Induced by Hydrogen Peroxide

Biomedicines, 2022
Idebenone is a ubiquinone short-chain synthetic analog with antioxidant properties, which is believed to restore mitochondrial ATP synthesis. As such, idebenone is investigated in numerous clinical trials for diseases of mitochondrial aetiology and it is
Maria Elisabetta Clementi, Giada Bianchetti, Anna Brancato   +2 more
exaly   +3 more sources

Idebenone alleviates doxorubicin-induced cardiotoxicity by stabilizing FSP1 to inhibit ferroptosis

Acta Pharmaceutica Sinica B
Doxorubicin (DOX)-mediated cardiotoxicity can exacerbate mortality in oncology patients, but related pharmacotherapeutic measures are relatively limited. Ferroptosis was recently identified as a major mechanism of DOX-induced cardiotoxicity. Idebenone, a
Hongliang Qiu, Sihui Huang, Yuting Liu, Libo Liu, Fengming Guo, Yingying Guo, Dan Li, Xianfeng Cen, Yajie Chen, Meng Zhang, Yan Che, Man Xu, Qizhu Tang   +12 more
exaly   +3 more sources