Results 11 to 20 of about 4,882 (214)

Effects of idebenone on cognitive function and serum biomarkers in patients with amnestic mild cognitive impairment [PDF]

European Journal of Medical Research
Objectives This retrospective study aimed to investigate the effects of idebenone on cognitive function and serum levels of superoxide dismutase (SOD) and high-sensitivity C-reactive protein (hs-CRP) in individuals with amnestic mild cognitive impairment
Huiting Wang, Xiaoling Wang, Weiwei Wang, Depeng Feng   +3 more
doaj   +2 more sources

Evaluation of Visual and Optical Coherence Tomography Outcomes in Patients with Leber’s Hereditary Optic Neuropathy Treated with Idebenone [PDF]

Life
The aim of this paper is to present our experience with the diagnosis and management of nine patients diagnosed with Leber’s hereditay optic neuropathy.
Raluca Eugenia Iorga, Andreea Dana Moraru, Răzvana Sorina Munteanu-Dănulescu, Delia Urdea, Ciprian Danielescu   +4 more
doaj   +2 more sources

Border between natural product and drug: Comparison of the related benzoquinones idebenone and coenzyme Q10

Redox Biology, 2015
Coenzyme Q10 is a ubiquitous component of cellular membranes and belongs to the class of benzoquinones that mainly differ with regards to the length and composition of their hydrophobic tail.
Jason A Smith, Nuri Güven
exaly   +3 more sources

Idebenone: Novel Strategies to Improve Its Systemic and Local Efficacy

Nanomaterials, 2018
The key role of antioxidants in treating and preventing many systemic and topical diseases is well recognized. One of the most potent antioxidants available for pharmaceutical and cosmetic use is Idebenone (IDE), a synthetic analogue of Coenzyme Q10 ...
Lucia Montenegro, Rita Turnaturi, Carmelo Puglia   +2 more
exaly   +3 more sources

Research Progress on Idebenone in Neurodegenerative Diseases. [PDF]

Aging Med (Milton)
The study not only summarizes the biological properties of Idebenone (IDE), including its role in improving mitochondrial function and antioxidative stress, but also explores its clinical research progress in various neurodegenerative diseases, providing a new perspective for the treatment of these disorders.
Zhang Y, Ren Y, Zhu X, Liu T, Han R, Fang Y, Zhao Z, Mao F, Wang Y, Li X, Li X.   +10 more
europepmc   +2 more sources

Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD

Biology, 2021
The coenzyme Q10 analogue idebenone is an FDA-approved antioxidant that can cross the blood–brain barrier (BBB). The effects of idebenone on the pathology of Alzheimer’s disease (AD) and the underlying molecular mechanisms have not been comprehensively ...
Hyun-ju Lee, Ha-Ram Jeong, Jin-Hee Park, Hyang-Sook Hoe   +3 more
doaj   +1 more source

Idebenone Regulates Aβ and LPS-Induced Neurogliosis and Cognitive Function Through Inhibition of NLRP3 Inflammasome/IL-1β Axis Activation

Frontiers in Immunology, 2022
Idebenone is an analogue of coenzyme Q10, an electron donor in the mitochondrial electron transport chain, and thus may function as an antioxidant to facilitate mitochondrial function.
Hyun-ju Lee, Jin-Hee Park, Hyang-Sook Hoe, Hyang-Sook Hoe   +3 more
doaj   +1 more source

Leber’s Hereditary Optic Neuropathy (LHON): Clinical Experience and Outcomes after Long-Term Idebenone Treatment

Life, 2023
Background: Leber’s hereditary optic neuropathy (LHON) is a rare disease. Large studies are difficult to conduct; therefore, case reports provide valuable data. Since 2015, patients have been treated with Idebenone.
George Baltă, Georgiana Cristache, Andreea Diana Barac, Nicoleta Anton, Ileana Ramona Barac   +4 more
doaj   +1 more source

Improving Sperm Oxidative Stress and Embryo Quality in Advanced Paternal Age Using Idebenone In Vitro—A Proof-of-Concept Study

Antioxidants, 2021
Advanced paternal age is associated with increased sperm reactive oxygen species (ROS) and decreased fertilization and pregnancy rates. Sperm washing during infertility treatment provides an opportunity to reduce high sperm ROS concentrations associated ...
Victoria Nikitaras, Deirdre Zander-Fox, Nicole O. McPherson   +2 more
doaj   +1 more source

Efficacy of idebenone in the Treatment of iRBD into Synucleinopathies (EITRS): rationale, design, and methodology of a randomized, double-blind, multi-center clinical study

Frontiers in Neurology, 2022
BackgroundAs the strongest prodromal marker of α-synuclein-specific neurodegeneration, idiopathic REM sleep behavior disorder (iRBD) is becoming a focus of interest in disease-modifying therapy. Idebenone has been widely portrayed as a potent antioxidant
Yuanyuan Li, Chunyi Wang, Ningdi Luo, Fangzheng Chen, Liche Zhou, Mengyue Niu, Wenyan Kang, Jun Liu, Jun Liu   +8 more
doaj   +1 more source