Results 91 to 100 of about 5,701,500 (381)

From genetic data to kinship clarity: employing machine learning for detecting incestuous relations

Frontiers in Genetics
Introduction:The aim of the study was to develop a predictive model based on STR profiles of mothers and children for the detection of incestuous conception.Methods:Based on allele frequency data from the USA and Saudi Arabia, STR profiles were generated
Dejan Šorgić, Aleksandra Stefanović, Mladen Popović, Dušan Keckarević   +3 more
doaj   +1 more source

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Sampling Local Fungal Diversity in an Undergraduate Laboratory using DNA Barcoding [PDF]

, 2014
Traditional methods for fungal species identification require diagnostic morphological characters and are often limited by the availability of fresh fruiting bodies and local identification resources.
Anderson, B. W., Bigott, A. F., Boone, M. J., Brick, S. M., delSol, J. F., Harrington, A. H., Hotchkiss, R. A., Huddleston, R. A., Kasper, E. H., McGrady, J. J., McKinnie, M. L., Ottenlips, M. V., Skinner, N. E., Spatz, K. C., Steinberg, A. J., van den Broek, F., Willyard, A. M., Wilson, C. N., Wofford, A. M   +18 more
core   +3 more sources

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Simultaneous lineage tracing and cell-type identification using CRISPR/Cas9-induced genetic scars

Nature Biotechnology, 2018
A key goal of developmental biology is to understand how a single cell is transformed into a full-grown organism comprising many different cell types.
B. Spanjaard, Bo Hu, N. Mitić, Pedro Olivares-Chauvet, Sharan Janjuha, N. Ninov, J. Junker   +6 more
semanticscholar   +1 more source

Systems approaches and algorithms for discovery of combinatorial therapies

, 2009
Effective therapy of complex diseases requires control of highly non-linear complex networks that remain incompletely characterized. In particular, drug intervention can be seen as control of signaling in cellular networks.
Agoston V, Balamurugan D, Calzolari D, Carlson JM, Greco WR, Johannesson GH, Nelander S, Segota E, Spall JC, Wadman M, Weinberg RA, Yang K   +11 more
core   +1 more source

Biomarker-Drug and Liquid Biopsy Co-development for Disease Staging and Targeted Therapy: Cornerstones for Alzheimer's Precision Medicine and Pharmacology. [PDF]

, 2019
Systems biology studies have demonstrated that different (epi)genetic and pathophysiological alterations may be mapped onto a single tumor's clinical phenotype thereby revealing commonalities shared by cancers with divergent phenotypes.
Goetzl, Edward J, Hampel, Harald, Kapogiannis, Dimitrios, Lista, Simone, Vergallo, Andrea   +4 more
core   +2 more sources

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source

Identification of a Unique TGF-β Dependent Molecular and Functional Signature in Microglia

Nature Neuroscience, 2013
Microglia are myeloid cells of the CNS that participate both in normal CNS function and in disease. We investigated the molecular signature of microglia and identified 239 genes and 8 microRNAs that were uniquely or highly expressed in microglia versus ...
O. Butovsky, Mark P. Jedrychowski, C. Moore, R. Cialic, Amanda J Lanser, Galina Gabriely, Thomas Koeglsperger, Ben Dake, Pauline M. Wu, Camille E. Doykan, Zain Fanek, Liping Liu, Zhuoxun Chen, J. Rothstein, R. Ransohoff, S. Gygi, J. Antel, H. Weiner   +17 more
semanticscholar   +1 more source

University Scholar Series: Brandon White [PDF]

, 2011
Use and Applications of HeLa Cells in Science and Biotechnology On October 26, 2011, Dr. Brandon White spoke in the University Scholar Series hosted by Provost Gerry Selter at the Dr. Martin Luther King, Jr. Library.
White, Brandon
core   +1 more source