Results 151 to 160 of about 41,008 (260)

IDH inhibition in gliomas

Nature Reviews Neurology
Gliomas are the most common malignant primary brain tumours in adults and cannot usually be cured with standard cancer treatments. Gliomas show intratumoural and intertumoural heterogeneity at the histological and molecular levels, and they frequently contain mutations in the isocitrate dehydrogenase 1 (IDH1) or IDH2 gene. IDH-mutant adult-type diffuse
Rudà, Roberta, Horbinski, Craig, van den Bent, Martin, Preusser, Matthias, Soffietti, Riccardo   +4 more
openaire   +1 more source

Larval diet breadth and wingspan mediate landscape–richness relationship in butterfly communities

Functional Ecology, Volume 40, Issue 3, Page 624-635, March 2026.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Landscape structure and species traits both shape butterfly assemblages, but their joint effects, and how landscapes restructure trait space independently of richness, remain less understood.
Dušanka Vujanović, Maja Knežević, Aleksandra Đorđević, Andrijana Andrić, Milica Ranković Perišić, Marina Janković Milosavljević, Sanja Veselić, Gianalberto Losapio, Maarten de Groot, Ante Vujić, Snežana Radenković   +10 more
wiley   +1 more source

Acceleration of Lactate Uptake and Utilization Contributes to Neuroprotective Action of FGF21 Involved in Naturally Aging Mice

Aging Cell, Volume 25, Issue 3, March 2026.
The left panel shows cerebral lactate homeostasis in young mice. The middle panel displays accelerated ANLS rates due to FGF21 secretion in aging mice. The right panel demonstrates that lactate uptake and usage inhibition contribute to lactate extracellular accumulation, followed by HCA1‐mediated learning and memory decline in mice.
Keru Ji, Hongde Wei, Ruguang Wang, Yutong Wu, Chen Li, Hongchang Gao, Liangcai Zhao   +6 more
wiley   +1 more source

Comparison of the normalized cerebral blood volume (CBV) between different models and evaluation of the efficacy of gadolinium leakage in evaluating preoperative adult-type gliomas. [PDF]

Quant Imaging Med Surg
Wang C, Zhang L, Song Y, Pan Z, Li G, Yuan X, Liu F.   +6 more
europepmc   +1 more source

IDH Gene Family [PDF]

, 2020
openaire   +1 more source

Supplementary Data: list of figures and tables from (R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

Kathryn Gunn, Matti Myllykoski, John Z. Cao, Manna Ahmed, Bofu Huang, Betty Rouaisnel, Bill H. Diplas, Michael M. Levitt, Ryan Looper, John G. Doench, Keith L. Ligon, Harley I. Kornblum, Samuel K. McBrayer, Hai Yan, Cihangir Duy, Lucy A. Godley, Peppi Koivunen, Julie-Aurore Losman   +17 more
openalex   +1 more source

IMG-109. Diagnostic accuracy of 2-hydroxyglutarate magnetic resonance spectroscopy for IDH mutation detection in gliomas: validation in a routine clinical setting [PDF]

André Sagerer, Judith Domanja, Amir Zolal, Mirko Peitzsch, Jennifer Linn, Ilker Y. Eyüpoglu, Annett Werner, Tareq A. Juratli   +7 more
openalex   +1 more source

Suppl. Figure 2 from Identification of CRKII, CFL1, CNTN1, NME2, and TKT as Novel and Frequent T-Cell Targets in Human IDH-Mutant Glioma

, 2023
Steffen Dettling, Slava Stamova, Rolf Warta, Martina Schnölzer, Carmen Rapp, Anchana Rathinasamy, David Reuß, Kolja Pocha, Saskia Roesch, Christine Jungk, Uwe Warnken, Volker Eckstein, Niels Grabe, Christoph Schramm, Markus A. Weigand, Andreas von Deimling, Andreas Unterberg, Philipp Beckhove, Christel Herold‐Mende   +18 more
openalex   +1 more source

CEO‐Board Social Ties and Corporate Tax Avoidance

Accounting &Finance, Volume 66, Issue 1, Page 259-285, March 2026.
ABSTRACT This study examines CEO‐board social ties that engage in corporate tax avoidance. We find that an increasing proportion of CEO‐board social ties in a firm is associated with higher levels of tax avoidance. Our results withstand several endogeneity tests, including propensity score matching, entropy balancing and a difference‐in‐differences ...
Chen Chen, Mukesh Garg, Dean Hanlon, Eka Nugraha Tan   +3 more
wiley   +1 more source

Vebreltinib for Previously Treated Astrocytoma, <i>IDH</i>-Mutant, Grade 4, and Glioblastoma, <i>IDH</i> Wild-Type with <i>PTPRZ1-MET</i> Fusion Gene: A Multicenter, Phase III Randomized, Open-Label Trial. [PDF]

Cancer Commun (Lond)
Bao Z, Xue Y, Liu Y, Li S, Wang L, Qu Y, Mou Y, Yu R, Wu J, Yao Y, Shu K, Hu G, Cai L, Li W, Qiu X, Li Y, Zhang L, Qi S, Ji Y, Ma C, Ma W, Li G, Tao R, Sun C, Chen L, Lv SQ, Liang P, Pan H, Peter WYM, Danny CTM, Mao Q, Wei X, Jiang T.   +32 more
europepmc   +1 more source