Results 231 to 240 of about 154,739 (326)

Deregulated enhancer‐promoter communication in cancer through altered nuclear architecture

International Journal of Cancer, Volume 158, Issue 2, Page 409-422, 15 January 2026.
Abstract Enhancers are critical regulators of gene expression. Structural variations in cancer genomes can lead to enhancer hijacking, where oncogenes are activated by mistargeted enhancer activity. Novel enhancer‐promoter interactions may also arise through chromosomal rearrangements that create extrachromosomal DNA elements.
Isabelle Seufert, Claire Vargas, Sina Jasmin Wille, Karsten Rippe   +3 more
wiley   +1 more source

Current Pharmacotherapeutic Strategies in Diffuse Gliomas: Focus on Glioblastoma, IDH-Wildtype, and Emerging Targeted Therapies for IDH-Mutant Tumors. [PDF]

Pharmaceuticals (Basel)
Dynarowicz K, Smolak B, Bartusik-Aebisher D, Guz W, Henrykowska G, Aebisher D.   +5 more
europepmc   +1 more source

Epigenetic reprogramming in multiple myeloma—Challenges and opportunities

International Journal of Cancer, Volume 158, Issue 2, Page 423-432, 15 January 2026.
Abstract In cancer, mutational processes act in concert with epigenetic reprogramming to endow malignant cells with hallmark properties that underpin tumorigenesis. Compared with the relatively rigid and slow processes of genetic evolution, the plastic nature of chromatin enables cells to adapt to a changing environment more rapidly.
Subhasree Kumar, Lev M. Kats, Emily Gruber   +2 more
wiley   +1 more source

Single-cell and spatial transcriptome sequencing analysis reveals characteristics of a unique subpopulation in high-grade IDH-mutant astrocytoma. [PDF]

Cell Oncol (Dordr)
Chen W, Zheng M, An JY, Huang GH, Liu JP, Yang L, Ren P, Wang TT, Hugnot JP, Lv SQ.   +9 more
europepmc   +1 more source

IDH Family Wildtype [PDF]

, 2020
openaire   +1 more source

New candidate gene mutations in astrocytoma with seizures. [PDF]

Sci Rep
Choochuen P, Khongcharoen N, Sangkhathat S, Kaewborisutsakul A, Tunthanathip T, Phabphal K.   +5 more
europepmc   +1 more source

Promoter Methylation-Expression Coupling of Gliogenesis Genes in IDH-Wildtype Glioblastoma: Longitudinal Analysis and Prognostic Value. [PDF]

Int J Mol Sci
Radu R, Tataranu LG, Dricu A, Alexandru O.   +3 more
europepmc   +1 more source

Issue Information

Brain Pathology, Volume 36, Issue 2, March 2026.
wiley   +1 more source

The TRiC/CCT Complex at the Crossroads of Metabolism and Hypoxia in GBM: Implications for IDH-Dependent Therapeutic Targeting. [PDF]

Int J Mol Sci
Alberti G, D'Amico G, Augello MA, Cappello F, Szychlinska MA, Caruso Bavisotto C, Scalia F.   +6 more
europepmc   +1 more source

Supplementary Data from Disabling Uncompetitive Inhibition of Oncogenic IDH Mutations Drives Acquired Resistance [PDF]

Junhua Lyu, Yuxuan Liu, Lihu Gong, Mingyi Chen, Yazan F. Madanat, Yuannyu Zhang, Feng Cai, Zhimin Gu, Hui Cao, Pranita Kaphle, Yoon Jung Kim, Fatma N. Kalkan, Helen Stephens, Kathryn E. Dickerson, Min Ni, Weina Chen, Prapti A. Patel, Alice S. Mims, Uma Borate, Amy Burd, Sheng F. Cai, C. Cameron Yin, M. James You, Stephen S. Chung, Robert H. Collins, Ralph J. DeBerardinis, Xin Liu, Jian Xu   +27 more
openalex   +1 more source