Results 31 to 40 of about 154,739 (326)
Mutant IDH in Gliomas: Role in Cancer and Treatment Options
Cancers, 2023 Simple Summary Isocitrate dehydrogenase (IDH) is the most mutated metabolic gene in human cancer. Mutations in this gene have been identified in a high percentage of gliomas, in acute myeloid leukemia (AML) and in many other malignancies.
G. Solomou +3 more
semanticscholar +1 more source
Cancer Discovery, 2023 Oncogenic mutations in isocitrate dehydrogenase (IDH)-1 and -2 occur in a wide range of cancers, including acute myeloid leukemia (AML) and glioma. Mutant IDH enzymes convert 2-oxoglutarate (2OG) to (R)-2-hydroxyglutarate ((R)-2HG)), an oncometabolite ...
K. Gunn +17 more
semanticscholar +1 more source
Cancers, 2023 Simple Summary To differentiate IDH-mutant grade 4 astrocytomas from IDH-wild-type glioblastomas, two MRI sequences (post-contrast T1 and T2-FLAIR) were acquired from 57 patients. The images were resliced, resampled, and realigned.
Seyyed Ali Hosseini +10 more
semanticscholar +1 more source
About the classification of the holonomy algebras of Lorentzian manifolds [PDF]
, 2013 The classification of the holonomy algebras of Lorentzian manifolds can be reduced to the classification of irreducible subalgebras $\mathfrak{h}\subset\mathfrak{so}(n)$ that are spanned by the images of linear maps from $\mathbb{R}^n$ to $\mathfrak{h ...
Galaev, Anton S.
core +1 more source
Stalled oligodendrocyte differentiation in IDH-mutant gliomas
Genome Medicine, 2023 Background Roughly 50% of adult gliomas harbor isocitrate dehydrogenase ( IDH ) mutations. According to the 2021 WHO classification guideline, these gliomas are diagnosed as astrocytomas, harboring no 1p19q co-deletion, or oligodendrogliomas, harboring ...
Yanfei Wei +17 more
semanticscholar +1 more source
Pictures, Content, and Normativity: The Semantic of Graphic Rules
Phenomenology and Mind, 2020 In our daily lives, we can find that different kinds of representational media are employed in normative ways, to express different kinds of rules. Sometimes, this is overlooked by the primacy of discursive representations in our normative practices ...
Mariela Aguilera
doaj +1 more source
Molecular and Genetic Determinants of Glioma Cell Invasion. [PDF]
, 2017 A diffusely invasive nature is a major obstacle in treating a malignant brain tumor, "diffuse glioma", which prevents neurooncologists from surgically removing the tumor cells even in combination with chemotherapy and radiation.
Kato, Yoichiro +4 more
core +2 more sources
Música Oral del Sur, 2023 Este texto busca problematizar los mecanismos involucrados en la producción de rótulos clasificatorios orientados a describir la música, y su relevancia como etiquetas sociológicas que también organizan la experiencia de la vida social en diversas ...
Rocío María Rodríguez
doaj +1 more source
Sujetos racializados en La(s) Habana(s) de Pedro Juan Gutiérrez y Ahmel Echevarría
Revista de Estudos Literários da UEMS - REVELL, 2021 En este trabajo, proponemos como ejercicio crítico la lectura relacional de El Rey de La Habana (1990), de Pedro Juan Gutiérrez y Caballo con arzones (pústulas)(2017), de Ahmel Echevarría - dos textos que, con veinte años de distancia escritural ...
Julieta Karol Kabalin Campos +1 more
doaj
Protein kinase B (PKB/AKT) protects IDH-mutated glioma from ferroptosis via Nrf2.
Clinical Cancer Research, 2023 PURPOSE Mutations of the isocitrate dehydrogenase (IDH) gene are common genetic mutations in human malignancies. Increasing evidence indicates that IDH mutations play critical roles in malignant transformation and progression.
Yang Liu +13 more
semanticscholar +1 more source