Results 41 to 50 of about 154,739 (326)

Genetic Differentiation Among Three Species of \u3ci\u3eParadosa\u3c/i\u3e (Arachnida: Lycosidae) [PDF]

, 2017
Allozymic variation in nine protein producing loci was examined in three species of Pardosa using starch gel electrophoresis. Allozyme frequencies showed a high degree of geographic uniformity among conspecific populations. Estimated heterozygosities for
Elliott, N. C, Engemann, J. G, Johnson, W. E, Wolff, R. J   +3 more
core   +2 more sources

PERK‐Mediated Cholesterol Excretion from IDH Mutant Glioma Determines Anti‐Tumoral Polarization of Microglia

Advancement of science, 2023
Isocitrate dehydrogenase (IDH) mutation, a known pathologic classifier, initiates metabolic reprogramming in glioma cells and has been linked to the reaction status of glioma‐associated microglia/macrophages (GAMs).
Tao Wang, Yunxia Zhou, Yunping Fan, H. Duan, Xiao-yu Guo, Jinlong Chang, Youheng Jiang, Chang-Xue Li, Z. Fu, Yunfei Gao, Xiaoran Guo, K. Sidlauskas, Zhenqiang He, Clive Da Costa, Xia Sheng, Dinglan Wu, Jinqiu Yuan, Huiliang Li, Yulong He, Y. Mou, Ningning Li   +20 more
semanticscholar   +1 more source

Weak Bialgebras of Fractions [PDF]

, 2012
We construct the algebra of fractions of a Weak Bialgebra relative to a suitable denominator set of group-like elements that is `almost central', a condition we introduce in the present article which is sufficient in order to guarantee existence of the ...
Bennoun, Steve, Pfeiffer, Hendryk
core   +1 more source

Fully Automated Hybrid Approach to Predict the IDH Mutation Status of Gliomas via Deep Learning and Radiomics.

Neuro-Oncology, 2020
BACKGROUND Glioma prognosis depends on the isocitrate dehydrogenase (IDH) mutation status. We aimed to predict the IDH status of gliomas from preoperative MR images using a fully automated hybrid approach with convolutional neural networks (CNNs) and ...
Y. Choi, S. Bae, Jong-Hee Chang, S. Kang, S. H. Kim, Jinna Kim, T. Rim, S. Choi, R. Jain, Seung-Koo Lee   +9 more
semanticscholar   +1 more source

Efficacy and safety of FDA-approved IDH inhibitors in the treatment of IDH mutated acute myeloid leukemia: a systematic review and meta-analysis

Clinical Epigenetics, 2023
Objective To systematically evaluate the efficacy and safety of FDA-approved isocitrate dehydrogenase (IDH) inhibitors in the treatment of IDH-mutated acute myeloid leukemia (AML).
Xiu-Yan Chen, H. Xing, Xiaolu Xie, Li-Duo Kou, Jun Li, Yaling Li   +5 more
semanticscholar   +1 more source

NADP(+)-isocitrate dehydrogenase from the cyanobacterium Anabaena sp. strain PCC 7120: purification and characterization of the enzyme and cloning, sequencing, and disruption of the icd gene [PDF]

, 1994
NADP(+)-isocitrate dehydrogenase (NADP(+)-IDH) from the dinitrogen-fixing filamentous cyanobacterium Anabaena sp. strain PCC 7120 was purified to homogeneity.
Florencio Bellido, Francisco Javier, Muro Pastor, María Isabel   +1 more
core   +2 more sources

Mutant IDH Inhibitors Induce Lineage Differentiation in IDH-mutant Oligodendroglioma [PDF]

, 2021
SummaryRecent data showed promising signs of objective tumor responses in subsets of patients with low grade glioma treated with inhibitors of mutant IDH (IDHi) (1). However, the molecular and cellular underpinnings of such responses are not known. Here, we profiled 6,039 transcriptomes by single-cell or single-nucleus RNA-sequencing isolated from ...
Avishay Spitzer, Simon Gritsch, Hannah R. Weisman, L. Nicolas Gonzalez Castro, Masashi Nomura, Nicholas Druck, Rony Chanoch-Myers, Christine K. Lee, Hiroaki Nagashima, Julie J. Miller, Isabel Arrillaga-Romany, David N. Louis, Hiroaki Wakimoto, Will Pisano, Patrick Y. Wen, Keith L. Ligon, Daniel P. Cahill, Mario L. Suvà, Itay Tirosh   +18 more
openaire   +1 more source

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Science, 2017
Single-cell RNA sequencing identifies a common origin for specific types of human glioma brain tumors. Effects of the tumor microenvironment Glioma brain tumors that carry mutant copies of the IDH gene can be subdivided into two major classes.
Andrew S. Venteicher, Andrew S. Venteicher, I. Tirosh, Christine Hebert, Christine Hebert, Keren Yizhak, Keren Yizhak, C. Neftel, C. Neftel, M. Filbin, M. Filbin, Volker Hovestadt, Volker Hovestadt, Leah E. Escalante, Leah E. Escalante, McKenzie L. Shaw, McKenzie L. Shaw, Christopher Rodman, Shawn M. Gillespie, Danielle Dionne, Christina C. Luo, Hiranmayi Ravichandran, Ravindra Mylvaganam, Christopher W. Mount, M. Onozato, B. Nahed, H. Wakimoto, W. Curry, A. Iafrate, Miguel Rivera, Miguel Rivera, M. Frosch, Todd R. Golub, Todd R. Golub, Todd R. Golub, P. Brastianos, G. Getz, G. Getz, Anoop P. Patel, Michelle Monje, D. Cahill, O. Rozenblatt-Rosen, D. Louis, Bradley E. Bernstein, Bradley E. Bernstein, A. Regev, A. Regev, A. Regev, Mario L. Suvà, Mario L. Suvà   +49 more
semanticscholar   +1 more source

IDH Mutations in Chondrosarcoma: Case Closed or Not?

Cancers, 2023
Simple Summary Chondrosarcomas are cartilage tumours that often harbour a mutation in one of the isocitrate dehydrogenase (IDH) genes. IDH mutations are important drivers at the beginning of cartilage tumour development, but their role in later stages ...
S. Venneker, J. Bovée
semanticscholar   +1 more source

Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma

Neuro-Oncology Advances, 2022
Background Treatment options for unresectable new and recurrent glioblastoma remain limited. Laser ablation has demonstrated safety as a surgical approach to treating primary brain tumors.
J. D. de Groot, A. Kim, S. Prabhu, Ganesh Rao, A. Laxton, P. Fecci, B. O'Brien, A. Sloan, Veronica S Chiang, S. Tatter, A. Mohammadi, D. Placantonakis, R. Strowd, Cl Chen, C. Hadjipanayis, M. Khasraw, D. Sun, D. Piccioni, K. Sinicrope, J. Campian, Sylvia C. Kurz, Brian J. Williams, Kris A Smith, Zulma Tovar-Spinoza, E. Leuthardt   +24 more
semanticscholar   +1 more source