Results 81 to 90 of about 154,739 (326)

Temozolomide and radiotherapy versus radiotherapy alone in patients with glioblastoma, IDH-wildtype: post-hoc analysis of the EORTC randomized phase 3 CATNON trial.

Clinical Cancer Research, 2022
PURPOSE In a post-hoc analysis of the CATNON trial (NCT00626990), we explored whether adding temozolomide to radiotherapy improves outcome in patients with IDH1/2wt anaplastic astrocytomas with molecular features of glioblastoma (redesignated as ...
C. M. S. Tesileanu, M. Sanson, W. Wick, A. Brandes, P. Clement, S. Erridge, M. Vogelbaum, A. Nowak, J. Baurain, W. Mason, H. Wheeler, O. Chinot, Sanjeev Gill, M. Griffin, L. Rogers, W. Taal, R. Rudà, M. Weller, C. Mcbain, M. V. van Linde, K. Aldape, R. Jenkins, J. Kros, P. Wesseling, A. von Deimling, Y. Hoogstrate, I. D. de Heer, P. Atmodimedjo, H. Dubbink, R. Brouwer, W. V. van Ijcken, Kin‐Jip Cheung, V. Golfinopoulos, B. Baumert, T. Gorlia, P. French, M. J. van den Bent   +36 more
semanticscholar   +1 more source

Association of CDKN2A/B Homozygous Deletion and Extent of Resection With Survival of Patients With WHO CNS5 Grade 4 Astrocytoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives WHO grade 4 astrocytomas are associated with poor prognosis, and their prognostic factors remain controversial. This study aimed to identify the prognostic factors and develop a management algorithm for these patients. Methods This study retrospectively included 151 CNS5 adult grade 4 astrocytomas from two medical centers.
Jiawei Cai, Guanglin Zhu, Qiu He, Chen Luo, Lingyun Zhuo, Xingfu Wang, Yiming Chen, Xiaoyong Chen, Wendong You, Jiaheng Xu, Yuanxiang Lin, Dezhi Kang, Shuai Wu, Zanyi Wu   +13 more
wiley   +1 more source

Impact of CDKN2A/B Homozygous Deletion on the Prognosis and Biology of IDH-Mutant Glioma

Biomedicines, 2022
Although hotspot mutations in isocitrate dehydrogenase (IDH) genes are associated with favorable clinical outcomes in glioma, CDKN2A/B homozygous deletion has been identified as an independent predicator of poor prognosis.
L. Huang
semanticscholar   +1 more source

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Atribución intencional en esquizofrenia de tipo desorganizada: una perspectiva davidsoniana

Tópicos, 2017
Actualmente se debate si el enfoque davidsoniano de la atribución intencional puede extenderse a casos de sujetos delirantes que sufren diversos trastornos psiquiátricos.
María Emilia Vilatta
doaj   +1 more source

Early onset acute lymphocytic interstitial pneumonitis (ALIP) in COVID-19 pathophysiology: preliminary lung autopsy findings

Sri Lanka Journal of Medicine, 2021
Sri Lanka is one of few countries which has performed post mortem examinations in deaths due to SARS CoV-2 virus (COVID-19) infection. At the office of the Judicial Medical Officer of National Institute of Infectious Diseases (NIID)/Infectious Disease ...
S. D. C. Perera
doaj   +1 more source

PDIA3 Inhibition Facilitates Sensitivity of IKE‐Induced Ferroptosis via STAT3/LCN2 Axis to Improve Glioblastoma Therapy

Advanced Science, EarlyView.
In this manuscript, protein disulfide isomerase A3 (PDIA3) is identified as a key factor mediating the susceptibility of ferroptosis in GBM. Inhibition of PDIA3 enhances IKE or cystine starvation‐induced ferroptosis in GBM cells by resulting in the accumulation of lipid peroxidation and a reduction in GSH level.
Jie Zhang, Wei Wang, Xin Liu, Peifen Lu, Xinjing Liu, Qiucheng Nie, Siyuan Xin, Hong Li, Donglin Yu, Xinyue Zhang, Kailong Li, Xiaomin Han, Shuping Zhang, Wei Chong, Lili Sun, Wei Li, Tao Xin, Jin Jiao, Qiang Ma, Yiju Wei   +19 more
wiley   +1 more source

Por una historia profesional y cívicamente responsable: los primeros años de la Nueva Escuela Histórica

Práticas da História, 2023
La Nueva Escuela Histórica nucleó a un grupo de historiadores argentinos, desde la segunda década de siglo XX, que, de la mano de un amplio despliegue institucional e importantes proyectos de difusión, buscaban definir con precisión los márgenes de la ...
María Carla Galfione
doaj   +1 more source

Predicting prognosis and IDH mutation status for patients with lower-grade gliomas using whole slide images

Scientific Reports, 2021
We developed end-to-end deep learning models using whole slide images of adults diagnosed with diffusely infiltrating, World Health Organization (WHO) grade 2 gliomas to predict prognosis and the mutation status of a somatic biomarker, isocitrate ...
Shuai Jiang, G. Zanazzi, S. Hassanpour
semanticscholar   +1 more source

Chloroplast Stress Signals Orchestrate Epidermis‐Specific Remodeling of Mitochondria and ER Under High Light

Advanced Science, EarlyView.
High light exposure triggers an epidermis‐specific remodeling of mitochondria and ER in Arabidopsis, driven by chloroplast‐derived signals. Live‐cell imaging shows that HL rapidly suppresses mitochondrial motility, followed by fusion‐driven elongation and ER cisternal expansion.
Evan R. Angelos, Hee‐Seung Choi, Jingzhe Guo, Andrea A. Zanini, Tessa M. Burch‐Smith, Emily Snyder, Matthew Part, Wilhelmina van de Ven, Manhoi Hur, Gerd Ulrich Balcke, Alain Tissier, Quanqing Zhang, Katayoon Dehesh   +12 more
wiley   +1 more source