Results 111 to 120 of about 571,282 (185)

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, Volume 20, Issue 10, Page 2510-2532, October 2026.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

IDH Mutation in the Progression of IDH-mutant Astrocytoma

My project investigated the role of isocitrate dehydrogenase (IDH) mutations in the progression of IDH-mutant astrocytoma, the most common brain malignancies in patients under age 55.
Cho, Lily
core  

The Price of Precision: A Critical Review of Molecular Diagnostics in Glioma, From Guidelines to Global Disparities

Annals of Clinical and Translational Neurology, Volume 13, Issue 10, Page 1968-1977, October 2026.
ABSTRACT Gliomas have undergone a profound redefinition over the past decade, transitioning from morphology‐based entities to biologically coherent diseases defined by molecular alterations. The 2021 WHO Classification of Tumors of the Central Nervous System and its 2022 update formalize this shift, establishing integrated diagnosis as the global ...
Maria Guarnaccia, Sebastiano Cavallaro
wiley   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, Volume 13, Issue 55, 5 October 2026.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Factors Associated With Perceived Cognitive Dysfunction in Patients With Primary Brain Tumors: The Utility of the Neuro‐QoL Cognition Function Scale

Cancer Medicine, Volume 15, Issue 10, October 2026.
ABSTRACT Background Primary brain tumor (PBT) patients commonly experience cognitive dysfunction. This study aims to describe the prevalence and factors associated with perceived cognitive function (PCF) in PBT patients enrolled in a natural history study (NCT02851706: Principal Investigator T. S. Armstrong).
Morgan Johnson, Kimberly Reinhart, Vivian A. Guedes, Michelle L. Wright, Elizabeth Vera, Alvina Acquaye‐Mallory, Hope Miller, Anna Choi, Tricia Kunst, Jennifer Reyes, Jing Wu, Marta Penas‐Prado, Byram Ozer, Eric Burton, Mark R. Gilbert, Terri S. Armstrong, Tito Mendoza   +16 more
wiley   +1 more source

Clinicopathologic Characteristics and Prognosis of Oligodendroglioma with IDH Mutation and 1p/19q Codeletion [PDF]

Objective To analyze the clinicopathological characteristics and prognosis of oligodendroglioma with IDH mutation and 1p/19q codeletion. Methods We collected the data of 54 oligodendroglioma patients with IDH mutation and 1p/19q codeletion.The patients ...
WANG Fang, DU Ziming, WU Xiaoyan, WANG Sujie, DENG Ling   +4 more
core   +1 more source

Deepening the Understanding of Platelet‐Derived RNA as Biomarker for Glioblastoma Through GSEA, TDEA, and Elastic Net Regularization Analysis

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Glioblastoma (GBM) is the most aggressive form of primary brain cancer. Blood platelets have emerged as biomarkers where their RNA expression pattern indicates a tumor's presence. Our study aimed to characterize these patterns to identify biological processes associated with GBM and to evaluate their potential as a non‐invasive ...
Anna Giczewska, Krzysztof Pastuszak, Leon van Hout, Edward Post, Jip Ramaker, Ken Zwaan, Anna Supernat, Bart A. Westerman   +7 more
wiley   +1 more source

Comprehensive characterization and database construction of immune repertoire in the largest Chinese glioma cohort

iScience
Summary: Immune receptor repertoire is valuable for developing immunotherapeutic interventions, but remains poorly understood across glioma subtypes including IDH wild type, IDH mutation without 1p/19q codeletion (IDHmut-noncodel) and IDH mutation with ...
Lu Wang, Zhiyuan Xu, Wei Zhang, Lin Li, Xiao Liu, Jing Zhang   +5 more
doaj   +1 more source

Precision Nutrition as the Concept of Dietary and Nutritional Interventions for Patients With Malignancies: A Narrative Literature Review and Perspectives

Cancer Reports, Volume 9, Issue 10, October 2026.
ABSTRACT Background Dietary and nutritional interventions have gained popularity among patients with cancer undergoing treatment due to the high cost of medical treatment and increased health awareness. Diet, nutrition, psychological stress, and adverse events during treatment have a significant impact on the quality of life of patients with cancer ...
Ken Yamaguchi, Koji Yamanoi, Jumpei Ogura, Ayami Koike, Maki Umemiya, Nozomi Higashiyama, Kazuhiro Kou, Yoshihide Inayama, Rin Mizuno, Taito Miyamoto, Mana Taki, Ryusuka Murakami, Junzo Hamanishi, Mandai Masaki   +13 more
wiley   +1 more source

Improved Method for Obtaining Patient‐Derived Glioblastoma Organoid and Primary Cells: A Generic and Simplified Approach for Intracranial Tumor With Minimized Input

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
An improved and simplified method enables the generation of primary tumor cells and tumoroids from the same tissue sample with minimal input, applicable universally to both intracranial and spinal tumors. Comparative analysis of drug screening results with patient follow‐up data allows for the assessment of individual drug sensitivity.
Siyuan Wang, Zhonggang Shi, Chihao Zhu, Dawei Dai, Xi Yang, Zhiyi Zhou, Qianying Qiu, Wenhua Sun, Yifeng Miao, Yongming Qiu   +9 more
wiley   +1 more source