Results 121 to 130 of about 571,282 (185)

METTL3 Increases Temozolomide Resistance in MGMT‐Negative Glioblastoma by Enhancing CBX5 mRNA Stability in an m6A‐IGF2BP2‐Dependent Manner

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
METTL3‐dependent m6A modification and IGF2BP2‐associated CBX5 mRNA stabilization help maintain CBX5 expression in MGMT‐negative glioblastoma. During temozolomide (TMZ) treatment, CBX5 contributes to ATM–RAD51‐associated signaling, limits persistent DNA damage and apoptosis, and thereby supports cell survival and TMZ resistance.
Hui Deng, Ruoyu Chen, Daohong Qu, Cifu Qu, Jia Shi   +4 more
wiley   +1 more source

Integrating Multimodal MRI Habitat and Transformer‐Based Pathomics to Predict High‐Risk Molecular Subtypes and Explore Biological Mechanisms in Adult Diffuse Gliomas

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
Based on the 2021 WHO CNS5 guidelines, this study introduces an integrated high‐risk molecular classification for gliomas and constructs a predictive model by combining multimodal MRI habitat imaging, Transformer‐based WSI pathomics, and clinical information.
Wenju Niu, Xin Duan, Xuan Li, Zehui Li, Qian Liang, Xiangli Yang, Yan Tan, Xiaochun Wang, Guoqiang Yang, Hui Zhang   +9 more
wiley   +1 more source

7 Tesla magnetic resonance spectroscopic imaging predicting IDH status and glioma grading

Cancer Imaging
Introduction With the application of high-resolution 3D 7 Tesla Magnetic Resonance Spectroscopy Imaging (MRSI) in high-grade gliomas, we previously identified intratumoral metabolic heterogeneities.
Cornelius Cadrien, Sukrit Sharma, Philipp Lazen, Roxane Licandro, Julia Furtner, Alexandra Lipka, Eva Niess, Lukas Hingerl, Stanislav Motyka, Stephan Gruber, Bernhard Strasser, Barbara Kiesel, Mario Mischkulnig, Matthias Preusser, Thomas Roetzer-Pejrimovsky, Adelheid Wöhrer, Michael Weber, Christian Dorfer, Siegfried Trattnig, Karl Rössler, Wolfgang Bogner, Georg Widhalm, Gilbert Hangel   +22 more
doaj   +1 more source

Mitochondrial Metabolic Reprogramming in Glioma: Mechanisms of Tumorigenesis and Implications for Clinical Therapy

CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.
In gliomas, mitochondria integrate glucose, lipid, protein, and nucleotide metabolism to support proliferation, invasion, treatment resistance, and adaptation, with D‐2‐hydroxyglutarate‐driven remodeling in IDH‐mutant tumors and diverse metabolic states in IDH wild‐type glioblastomas.
Liangqi Jiang, Mingrui Li, Zhen Li, Qing Liu, Yang Li   +4 more
wiley   +1 more source

Systemic Treatments for Recurrent or Metastatic Sinonasal Carcinomas: A Retrospective Multicenter Study

Head &Neck, Volume 48, Issue 10, Page 2810-2820, October 2026.
ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange, Mathilde Morisseau, Justin Michel, Thibaut Reverdy, Sylvain Morinière, Amaury Daste, Maxime Humbert, Caroline Viala, Pauline Corbaux, Tiffany Darbas, François‐Régis Ferrand, Valentin Favier, Camille Evrard, Diane Evrard, Delphine Farneti, Sarah Betrian‐Lagarde, Victor Sarradin   +16 more
wiley   +1 more source

IDH mutation is paradoxically associated with higher 18F-FDOPA PET uptake in diffuse grade II and grade III gliomas

, 2017
International audiencePurpose: The World Health Organization Classification of Tumors of the Central Nervous System has recently been updated by the integration of diagnostic and prognostic molecular parameters, giving pivotal attention to IDH mutation ...
Sala, Q., Ph. Metellus, E. Bialecki, D. Figarella-Branger, A. Verger, Q. Sala, O. Chinot, E. Guedj, Chinot, O., Taieb, D., Metellus, Ph., Figarella-Branger, D., D. Taieb, Bialecki, E., Guedj, Eric, Verger, A., C. Colin, Colin, C.   +17 more
core   +1 more source

The Microbiome in Glioblastoma: Mechanisms, Tumor–Immune Interactions, and Translational Perspectives

MicrobiologyOpen, Volume 15, Issue 5, October 2026.
Proposed microbiome‐related pathways and translational landscape in glioblastoma. Gut dysbiosis may alter microbial metabolites, inflammatory mediators, barrier integrity, immune signaling, and vagal communication, thereby influencing the GBM neuroimmune microenvironment.
Tareq Nayef AlRamadneh, Renuka Jyothi‐S, Priya Priyadarshini‐Nayak, Anima Nanda, Shaker Al‐Hasnaawei, Akanksha Bhatt, Ashish Singh‐Chauhan, Siya Singla, Manoj Kumar Mishra   +8 more
wiley   +1 more source

A State‐Resolved Single‐Cell and Spatial Atlas Reveals IDH‐Associated Differences in Malignant and Immune Architecture in Diffuse Glioma

MedComm, Volume 7, Issue 10, October 2026.
Single‐cell and spatial transcriptomic profiling of 69 adult‐type diffuse gliomas revealed seven recurrent malignant cell states. GBMs were enriched for astrocyte‐like progenitor, hypoxic, and proliferative states, with higher T‐ and myeloid‐cell infiltration but transcriptional immune suppression.
Ashraf Zaman, Emily Holton, Madhavi Pandya, Genevieve Shillington, Cecile Escher, Kavitha Krishna Sudhakar, Agota Tuzesi, Ashish Mehta, Eric Lam, Rachael Zekanovic, Michael Sughrue, Charlie Teo, Jacky Yeung, Walter Muskovic, Joseph E. Powell   +14 more
wiley   +1 more source

TP53 Mutation Heterogeneity Refines Prognostic Stratification in IDH‐Wildtype Glioma

MedComm, Volume 7, Issue 10, October 2026.
This study reveals that TP53 mutations in IDH‐wildtype gliomas are prognostically heterogeneous. A variant allele frequency (VAF) ≥10% identifies a high‑risk subgroup, and mutations located in the β‑strand region of the DNA‑binding domain confer the poorest outcomes.
Kuilin Liao, Zhi Ye, Songtao Qi, Chang Xu, Yudi Huang, Zhiyong Li, Guozhong Yi, Yuou Qin, Qiuming Pan, Guiling Liu, Chao Chen, Zhuoyang Chen, Hongrui Li, Junxi Wang, Xi'an Zhang, Guanglong Huang, Shanqiang Qu   +16 more
wiley   +1 more source

Feasibility of Spin‐ and Gradient‐Echo Dynamic Susceptibility Contrast MRI for Microvascular Characterization at 7 Tesla

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Spin‐ and‐gradient‐echo DSC MRI at 7 T allows for characterization of the microvasculature at an improved resolution and a reduced gadolinium‐based contrast agent dosage while maintaining increased vascular contrast. Ratios between normal‐appearing gray matter and white matter for relative cerebral blood volume and vessel size estimates were similar ...
Karen N. van der Werff, Daniëlle van Dorth, Krishnapriya Venugopal, Esther A. H. Warnert, Dirk H. J. Poot, Frans M. Vos, Marion Smits, Stefan Klein, C. Chad Quarles, Juan A. Hernandez‐Tamames, Johan A. F. Koekkoek, Jeroen de Bresser, Matthias J. P. van Osch   +12 more
wiley   +1 more source