Results 91 to 100 of about 3,776 (207)

Middle Cranial Fossa (MCF) Approach without the use of Lumbar Drain for the Management of Spontaneous Cerebral Spinal Fluid (CSF) Leaks [PDF]

, 2016
Objective: To determine the efficacy and morbidity of repairing spontaneous cerebrospinal fluid (CSF) leaks with the middle cranial fossa (MCF) approach without the use of a lumbar drain (LD), as perioperative use of LD remains controversial.
Gantz, Bruce J., Hansen, Marlan R., Nelson, Rick F., Roche, Joseph P.   +3 more
core   +1 more source

Assessing Condition‐Specific Adverse Event Profiles of Modafinil for Labelled and Off‐Label Uses: A Systematic Review and Meta‐Analysis

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 1, January 2026.
ABSTRACT Modafinil is approved for excessive daytime sleepiness in narcolepsy, obstructive sleep apnoea (OSA), and shift work sleep disorder (SWSD), but its widespread off‐label use raises safety concerns. We evaluated the risk of adverse events (AEs) associated with both labelled and off‐label use of modafinil.
Jaehee Jung, Jaeyoon Youm, Jihyun Kang, Ah‐Young Kim, Jae Kyung Suh, Hye‐Young Kang   +5 more
wiley   +1 more source

Workplace Implications of Idiopathic Hypersomnia in the Setting of Occupational Sleep Medicine: A Case Report and Literature Review

Journal of Sleep Sciences, 2020
Background and Objective: Idiopathic hypersomnia (IH) manifests with excessive daytime sleepiness (EDS), cogni-tive and autonomic symptoms, debilitating sleep inertia, difficulty awakening, prolonged sleep duration, and non-restorative sleep.
Arezu Najafi, Khosro Sadeghniiat-Haghighi, Ania Rahimi-Golkhandan   +2 more
doaj  

Efficacy and Safety of Lower-Sodium Oxybate in an Open-Label Titration Period of a Phase 3 Clinical Study in Adults with Idiopathic Hypersomnia

Nature and Science of Sleep, 2022
Michael J Thorpy,1 Isabelle Arnulf,2 Nancy Foldvary-Schaefer,3 Anne Marie Morse,4 Karel Šonka,5 Patricia Chandler,6 Luke Hickey,7 Abby Chen,6 Jed Black,6,8 Amanda Sterkel,6 Dan Chen,9 Richard K Bogan,10 Yves Dauvilliers11,12 1Albert Einstein ...
Thorpy MJ, Arnulf I, Foldvary-Schaefer N, Morse AM, Šonka K, Chandler P, Hickey L, Chen A, Black J, Sterkel A, Chen D, Bogan RK, Dauvilliers Y   +12 more
doaj  

CSF prostaglandin D synthase is reduced in excessive daytime sleepiness [PDF]

, 2018
Lipocalin-type prostaglandin D synthase (L-PGDS) is a brain enzyme, which produces prostaglandin D2, a substance with endogenous somnogenic effects. Using a standardized protocol for immunonephelometric determination of cerebrospinal fluid (CSF) L-PGDS ...
Bassetti, Claudio, Baumann, Christian, Hersberger, Martin   +2 more
core  

Modafinil restores memory performance and neural activity impaired by sleep deprivation in mice. [PDF]

, 2007
The original aims of our study have been to investigate in sleep-deprived mice, the effects of modafinil administration on spatial working memory, in parallel with the evaluation of neural activity level, as compared to non-sleep-deprived animals.
Béracochéa, Daniel, Chauveau, Frédéric, Drouet, Isabelle, Jouanin, Jean-Claude, Lafon, Thierry, Liscia, Pierrette, Mons, Nicole, Philippin, Jean-Nicolas, Piérard, Christophe, Serra, André, van Beers, Pascal   +10 more
core   +3 more sources

Successful Treatment of Secondary Hypersomnia Due to Complex Post-Traumatic Stress Disorder with Eye Movement Desensitization and Reprocessing: A Case Report

Clocks & Sleep
Hypersomnia may be classified as primary or secondary, with secondary hypersomnia arising from a variety of underlying causes. Thus, according to ICSD3-TR classification, the diagnosis of idiopathic hypersomnia (IH) is established based on (1) excessive ...
Vlad Bucurescu, Laure Peter-Derex, Maria Livia Fantini, Benjamin Putois   +3 more
doaj   +1 more source

[18F]Fludeoxyglucose-Positron Emission Tomography Evidence for Cerebral Hypermetabolism in the Awake State in Narcolepsy and Idiopathic Hypersomnia

Frontiers in Neurology, 2017
BackgroundChanges in structural and functional central nervous system have been reported in narcolepsy, with large discrepancies between studies. No study has investigated yet spontaneous brain activity at wake in idiopathic hypersomnia (IH). We compared
Yves Dauvilliers, Yves Dauvilliers, Elisa Evangelista, Elisa Evangelista, Delphine de Verbizier, Lucie Barateau, Lucie Barateau, Philippe Peigneux   +7 more
doaj   +1 more source

A fixed-dose randomized controlled trial of olanzapine for psychosis in Parkinson disease [PDF]

, 2013
Background: Psychosis is a common and debilitating side effect of long-term dopaminergic treatment of Parkinson disease (PD). While clozapine is an effective treatment, the need for blood monitoring has limited its first-line use.
Black, Kevin J, Eicken, Meredith G.A, Hartlein, Johanna M, Nichols, Michelle J, Racette, Brad A   +4 more
core   +3 more sources

Refractory Obstructive Sleep Apnea in a Patient with Diffuse Idiopathic Skeletal Hyperostosis

Case Reports in Otolaryngology, 2016
Diffuse Idiopathic Skeletal Hyperostosis (DISH) can cause ossification of ligaments and may affect the spine. We report a case of obstructive sleep apnea in a patient with significant upper airway narrowing secondary to cervical DISH. This patient had an
Ara Darakjian, Ani B. Darakjian, Edward T. Chang, Macario Camacho   +3 more
doaj   +1 more source