Results 31 to 40 of about 2,114 (125)

Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs, Caitlin E. Martin, Bernard Fuemmeler, Shanshan Chen   +3 more
wiley   +1 more source

Risk of Hypertension and Mortality Among People With Narcolepsy or Idiopathic Hypersomnia: A Retrospective Cohort Analysis of the Danish National Patient Registry

Journal of Sleep Research, EarlyView.
This retrospective cohort study using data from the Danish National Patient Registry shows that individuals with narcolepsy or idiopathic hypersomnia have greater prevalence and risk of incident hypertension compared with matched controls, highlighting the elevated cardiovascular risk associated with these conditions.
Poul Jørgen Jennum, Michael Ibsen, Sam Mettam, Sarah C. Markt, Douglas S. Fuller, Jessica K. Alexander, Rikke Ibsen, Jakob Kjellberg, Caroleen Drachenberg   +8 more
wiley   +1 more source

Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life

Journal of Sleep Research, EarlyView.
Network Analysis in Central Disorders of Hypersomnolence: Insight Into Relationships Between Symptoms, Mental Health, and Quality of Life. ABSTRACT In the central disorders of hypersomnolence (CDH) narcolepsy types 1 and 2 (NT1, NT2) and idiopathic hypersomnia (IH), mental health problems are highly prevalent, and quality of life is decreased.
Denise Bijlenga, Tessa F. Blanken, Josephine J. de Boer, Rolf Fronczek, Gert Jan Lammers   +4 more
wiley   +1 more source

Impaired Alertness Correlates With Chronic Anxiety: A Prospective Tertiary University Centre Cohort

Journal of Sleep Research, EarlyView.
ABSTRACT The Maintenance of Wakefulness Test (MWT) is a widely used objective measure of daytime alertness, especially in patients with sleep disorders at increased risk of accidents. Anxiety and depression are common in this population and may influence subjective sleepiness and objective alertness.
Anice Borjon, Lucie Bobin, François Ricordeau, Lucas Marces, Hugo Fornelli, Thierry Petitjean, Amandine Viccica, Elena Charbonnier, Emeric Stauffer, Barbara Charbotel, Jacques Taillard, Renaud Tamisier, Laure Peter‐Derex, Pierre Tankéré   +13 more
wiley   +1 more source

Long-Term Treatment of Narcolepsy and Idiopathic Hypersomnia with Low-Sodium Oxybate

Nature and Science of Sleep, 2023
Logan D Schneider,1 Anne Marie Morse,2 Michael J Strunc,3 Joyce K Lee-Iannotti,4 Richard K Bogan5 1Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA; 2Janet Weis Children’s Hospital, Geisinger ...
Schneider LD, Morse AM, Strunc MJ, Lee-Iannotti JK, Bogan RK   +4 more
doaj  

The melanopsin-mediated pupil response is reduced in idiopathic hypersomnia with long sleep time

Scientific Reports, 2022
Idiopathic hypersomnia (IH), characterized by an excessive day-time sleepiness, a prolonged total sleep time on 24 h and/or a reduced sleep latency, affects 1 in 2000 individuals from the general population.
Héloïse Rach, Ulker Kilic-Huck, Eve Reynaud, Laurence Hugueny, Emilie Peiffer, Virginie Roy de Belleplaine, Fanny Fuchs, Patrice Bourgin, Pierre A. Geoffroy   +8 more
doaj   +1 more source

Targeting Orexin 2 Receptors in Idiopathic Hypersomnia and Narcolepsy: A Randomised Phase 1b Proof‐Of‐Concept Study of Alixorexton

Journal of Sleep Research, EarlyView.
Orexin 2 receptor agonists have demonstrated that targeting the orexin system may address symptoms of central disorders of hypersomnolence. Results of this phase 1 study support the phase 2 clinical evaluation of oral alixorexton in patients with IH, NT2 and NT1.
Ronald R. Grunstein, Brendon J. Yee, Julia L. Chapman, Jian Eu Tai, Sheila Sivam, Craig Hopkinson, Daniel G. Smith, Alexandra Lovett, Shifang Liu, Sergey Yagoda, Bhaskar Rege   +10 more
wiley   +1 more source

Oral Health–Related Quality of Life and Depressive Symptoms in Oral Mucosal Diseases: A Cross‐Sectional Observational Pilot Study

Oral Diseases, EarlyView.
ABSTRACT Objectives To evaluate the association between oral mucosal diseases, oral health‐related quality of life (OHRQoL), and depressive symptoms, and to explore differences across categories. Materials and Methods In this cross‐sectional observational pilot study, consecutive outpatients with oral mucosal disease were enrolled at the Dental Clinic ...
Domenico Cutecchia, Tommaso Marvulli, Vittorio Dibello, Alberta Lucchese, Massimo Petruzzi, Domenico De Falco   +5 more
wiley   +1 more source

Compromised Dynamic Cerebral Autoregulation in Patients With Central Disorders of Hypersomnolence

Frontiers in Neurology, 2021
Objective: We aimed to investigate the dynamic cerebral autoregulation (dCA) in patients with central disorders of hypersomnolence during wakefulness.Methods: Thirty-six patients with central disorders of hypersomnolence were divided into three groups ...
Fang Deng, Yanan Zhang, Ran Zhang, Qi Tang, Zhenni Guo, Yudan Lv, Zan Wang, Yi Yang   +7 more
doaj   +1 more source

Slow Wave Activity During Nocturnal Sleep in Hypersomnolence Disorder

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Slow waves during non‐rapid eye movement (NREM) sleep are associated with the restorative aspects of sleep. Previous research has suggested reduced normalized slow wave activity (SWA), particularly in the first cycle of NREM sleep, as a feature of hypersomnolence disorder (HD); however, the scarcity of existing research highlights the need for
Jesse D. Cook, Brady A. Riedner, Meredith E. Rumble, Michael R. Goldstein, Ana Maria Vascan, Kieulinh M. Tran, David T. Plante   +6 more
wiley   +1 more source