Results 51 to 60 of about 3,776 (207)

Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns. [PDF]

, 2014
Narcolepsy is a chronic sleep disorder, likely with an autoimmune component. During 2009 and 2010, a link between A(H1N1)pdm09 Pandemrix vaccination and onset of narcolepsy was suggested in Scandinavia.
A. Cederlund, A. Huutoniemi, Adamantidis, Ahnaou, Aran, B. Agerberth, B. Horvath, Beuckmann, Bittencourt, C. Adori, Chastrette, Conzelmann, Cvetkovic-Lopes, D. Kostyalik, Dauvilliers, David, de Lecea, Diniz Behn, Frisullo, G. Bagdy, Gao, Geis, Gonzalez-Albo, Hallmayer, Han, Hara, Hublin, I. Julkunen, Israeli, Kantor, Kitka, Konadhode, Koo, Kornum, L. Kalmar, Li, Longstreth, M. Partinen, Maulon-Feraille, Mignot, NAHON, Overeem, P. Bergman, Panskepp, Partinen, Peyron, Peyron, Qiu, Rao, Rovere, S. Vas, Sakurai, Saper, Saper, Sasaki, Scammell, T. Hokfelt, T. Sarkanen, Tamamaki, Thannickal, Tsunematsu, van den Pol, Verret, Viale, Watson, Y. Kai-Larsen, Zhang   +66 more
core   +1 more source

Profiling the sleep architecture of ageing adults using a seven‐state continuous‐time Markov model

Journal of Sleep Research, Volume 34, Issue 2, April 2025.
Summary Sleep is a complex biological process regulated by networks of neurons and environmental factors. As one falls asleep, neurotransmitters from sleep–wake regulating neurones work in synergy to control the switching of different sleep states throughout the night. As sleep disorders or underlying neuropathology can manifest as irregular switching,
Jonathon Jacobs, Caitlin E. Martin, Bernard Fuemmeler, Shanshan Chen   +3 more
wiley   +1 more source

Compromised Dynamic Cerebral Autoregulation in Patients With Central Disorders of Hypersomnolence

Frontiers in Neurology, 2021
Objective: We aimed to investigate the dynamic cerebral autoregulation (dCA) in patients with central disorders of hypersomnolence during wakefulness.Methods: Thirty-six patients with central disorders of hypersomnolence were divided into three groups ...
Fang Deng, Yanan Zhang, Ran Zhang, Qi Tang, Zhenni Guo, Yudan Lv, Zan Wang, Yi Yang   +7 more
doaj   +1 more source

Obstructive sleep apnea and ocular disorders. [PDF]

, 2010
PURPOSE OF REVIEW: Obstructive sleep apnea is a diagnosis that ophthalmologists can screen for when a patient presents with certain risk factors. Recent literature provides strong data for associations between sleep apnea and ocular disorders.
Grover, Deepak P.
core   +2 more sources

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, EarlyView.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source

Investigation of the “Not Better Explained” Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review

Journal of Sleep Research, EarlyView.
The “Not Better Explained” (NBE) criterion plays a key role in preventing diagnostic misclassification by structuring causal reasoning in sleep medicine. This systematic content analysis compares the use, wording, and excluded conditions of NBE criteria across the ICSD‐3‐TR and DSM‐5‐TR for ten major sleep disorders.
Jean‐Arthur Micoulaud‐Franchi, Vincent P. Martin, Julien Coelho, Régis Lopez, Pierre‐Alexis Geoffroy, Laure Peter‐Derex, Isabelle Lambert, Charles M. Morin, Clélia Quiles, Christophe Gauld   +9 more
wiley   +1 more source

Narcolepsy [PDF]

, 2007
BACKGROUND: Narcolepsy is a chronic neurological syndrome with prevalence between 0.018% and 0.040% without important ethnic differences. Narcolepsy is characterized by excessive daytime sleepiness and cataplexy. The pathophysiology of the illness is not
Bittencourt, Lia Rita Azeredo, Coelho, Fernando Morgadinho Santos, Elias, Rosilene Motta, Pradella-Hallinan, Márcia Lurdes de Cássia, Tufik, Sergio   +4 more
core   +3 more sources

Supply and Demand in the Mathematics of Rare Disease Drug Development: Why Choosing the Right Model Is Crucial

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Clinical trials for rare diseases face a fundamental mathematical challenge that conventional randomized controlled trial (RCT) designs cannot overcome. With approximately 95% of the estimated 10,000–16,000 rare diseases lacking approved therapies, and drug development programs failing at rates exceeding 75% in non‐oncology indications, the ...
Marshall L. Summar, Janet Woodcock
wiley   +1 more source

Modafinil dependence: A case with attention-deficit/hyperactivity disorder [PDF]

, 2018
Modafinil is generally known as a drug with low addiction potential. There are few case reports in the literature demonstrating that Modafinil, stated being capable of diminishing symptoms of attention deficit/hyperactivity disorder (ADHD), causes ...
Alaçam, Hüseyin, Başay, Ömer, Kar, G., Mart, M., Tümkaya, Selim   +4 more
core   +1 more source

Idiopathic hypersomnia and Kleine–Levin syndrome

Revue Neurologique, 2023
Idiopathic hypersomnia (IH) and Kleine-Levin syndrome (KLS) are rare disorders of central hypersomnolence of unknown cause, affecting young people. However, increased sleep time and excessive daytime sleepiness (EDS) occur daily for years in IH, whereas they occur as relapsing/remitting episodes associated with cognitive and behavioural disturbances in
Arnulf, I., Dodet, Pauline, Leu-Semenescu, Smaranda, Maranci, J.B.   +3 more
openaire   +3 more sources