Results 61 to 70 of about 2,437 (180)

Slow Wave Activity During Nocturnal Sleep in Hypersomnolence Disorder

Journal of Sleep Research, EarlyView.
ABSTRACT Slow waves during non‐rapid eye movement (NREM) sleep are associated with the restorative aspects of sleep. Previous research has suggested reduced normalized slow wave activity (SWA), particularly in the first cycle of NREM sleep, as a feature of hypersomnolence disorder (HD); however, the scarcity of existing research highlights the need for
Jesse D. Cook, Brady A. Riedner, Meredith E. Rumble, Michael R. Goldstein, Ana Maria Vascan, Kieulinh M. Tran, David T. Plante   +6 more
wiley   +1 more source

Lyme borreliosis presenting as hypersomnia [PDF]

, 2010
Hypersomnia is known to be associated with symptoms, such as excessive daytime sleepiness, headache, and decreases in vigilance. We report for the first time a patient who initially presented with symptoms for idiopathic hypersomnia but after a thorough ...
Dalal, M A, Wehrle, R, Beitinger, P A, Wetter, T C   +3 more
core   +1 more source

Diagnostic Value of Psychomotor Vigilance Task for Severe Sleep Inertia in Idiopathic Hypersomnia Versus Other Sleep Disorders Without Sleep Inertia

Journal of Sleep Research, EarlyView.
Diagnostic Value of PVT for Severe Sleep Inertia in Idiopathic Hypersomnia. ABSTRACT Sleep inertia impairs performance upon awakening and may be assessed using the psychomotor vigilance task (PVT). This study aimed to determine optimal PVT lapse cut‐offs at awakening to objectively measure sleep inertia by comparing patients with idiopathic hypersomnia
Elisa Evangelista, Alexandre Derré, Lucie Barateau, Anna Laura Rassu, Sofiene Chenini, Isabelle Jaussent, Yves Dauvilliers   +6 more
wiley   +1 more source

Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat

Orphanet Journal of Rare Diseases, 2020
Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi, T. Kawazoe, Y. Hamada, T. Kumagai, K. Tsutsui, N. Sakai, K. Eto, A. Noguchi, T. Shimizu, T. Takahashi, G. Han, K. Mishima, T. Kanbayashi, H. Kondo   +13 more
doaj   +1 more source

Eyelid Closure Behavior of Patients with Idiopathic and Nonorganic Hypersomnia, Narcolepsy-Cataplexy, and Healthy Controls in the Maintenance of Wakefulness Test [PDF]

, 2023
PURPOSE Differential diagnosis of central disorders of hypersomnolence remains challenging, particularly between idiopathic (IH) and nonorganic hypersomnia (NOH). We hypothesized that eyelid closure behavior in the maintenance of wakefulness test (MWT)
Schreier, David R, Mathis, Johannes, Hertig-Godeschalk, Anneke, Schmitt, Wolfgang, David R Schreier, Wolfgang J Schmitt, Uli S Herrmann, Knobel, Samuel E J, Santschi, Annelies, Johannes Mathis, Herrmann, Uli S, Jelena Skorucak, Anneke Hertig-Godeschalk, Samuel EJ Knobel, Skorucak, Jelena, Annelies Santschi   +15 more
core   +1 more source

Machine Learning for Diagnosis and Differentiation of Central Disorders of Hypersomnolence: A Systematic Review

European Journal of Neurology, Volume 33, Issue 6, June 2026.
This graphical abstract presents the review process (including 41 studies). It highlights the use of machine learning techniques in adults with CDH, such as unsupervised learning for phenotype discovery and supervised learning for diagnosis classification. The figure summarizes the strengths and limitations of each approach, along with key clinical and
Annina Helmy, Livia G. Fregolente, Marc von Gernler, Rafael Morand, Julia van der Meer, Markus Schmidt, Stavroula Mougiakakou, Athina Tzovara, Claudio L. A. Bassetti   +8 more
wiley   +1 more source

Supply and Demand in the Mathematics of Rare Disease Drug Development: Why Choosing the Right Model Is Crucial

Clinical and Translational Science, Volume 19, Issue 5, May 2026.
ABSTRACT Clinical trials for rare diseases face a fundamental mathematical challenge that conventional randomized controlled trial (RCT) designs cannot overcome. With approximately 95% of the estimated 10,000–16,000 rare diseases lacking approved therapies, and drug development programs failing at rates exceeding 75% in non‐oncology indications, the ...
Marshall L. Summar, Janet Woodcock
wiley   +1 more source

Prevalence of Insomnia, Nightmares and Obstructive Sleep Apnea Among Medical Students: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 4, April 2026.
ABSTRACT Background and Aims This study investigates the prevalence of insomnia, nightmares, and obstructive sleep apnea among medical students and their correlation with several variables. Methods We gathered data from six medical colleges across Syrian universities, focusing on second to sixth‐year human medicine students. The questionnaire, based on
Mohamad Ala Rashi, Khaled Alkhateeb, Hamza Altabbaa, Ali Hsamo, Yahia Almouie, Mohamad Omar Harbeh, Maysoun Kudsi, Data collaborators, Sally jabbour, Ghadeer Eskandar Jawish, Sedra Sahly, Maya Ghanem, Nour Zrba   +12 more
wiley   +1 more source

Narcolepsy vs. idiopathic hypersomnia: differentiating groups using cluster analysis [PDF]

, 2018
This thesis aims to address several issues encountered in the differential diagnosis of narcolepsy. According to the ICSD 3, narcolepsy is divided into two subtypes, narcolepsy type 1 and type 2. Narcolepsy type 1 has been shown to be caused by a loss of
Sitka, Emanuel
core  

Car Crashes and Central Disorders of Hypersomnolence: A French Study. [PDF]

PLoS ONE, 2015
Drowsiness compromises driving ability by reducing alertness and attentiveness, and delayed reaction times. Sleep-related car crashes account for a considerable proportion of accident at the wheel.
Fabio Pizza, Isabelle Jaussent, Regis Lopez, Carole Pesenti, Giuseppe Plazzi, Xavier Drouot, Smaranda Leu-Semenescu, Severine Beziat, Isabelle Arnulf, Yves Dauvilliers   +9 more
doaj   +1 more source