Results 41 to 50 of about 2,114 (125)

Hipersomnia idiopática: desconocida y polimórfica

Revista Médica Clínica Las Condes, 2021
Resumen: La hipersomnia idiopática (HI) es una patología frecuentemente crónica, incapacitante, polimórfica, de etiología y prevalencia desconocida. No existen marcadores biológicos ni test diagnósticos específicos, alcanzando el diagnóstico definitivo ...
Mónica González
doaj   +1 more source

Postmortem Evidence of CRH Neuron Reduction in Narcolepsy Without Cataplexy With Borderline Hypocretin‐1 Levels

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Narcolepsy is classified as type 1 (NT1) or type 2 (NT2) mainly according to hypocretin deficiency rather than cataplexy. While CRH neuron loss in the PVN has been described in NT1, it remains unclear whether similar changes occur in narcolepsy without cataplexy.
Ling Shan, Suzan Linssen, Rolf Fronczek, Lucie Barateau, Christelle Peyron, Yves Dauvilliers   +5 more
wiley   +1 more source

Differences in Sleep Spindle Characteristics Between Children With Narcolepsy and Those With Other Causes of Subjective Sleepiness

Journal of Sleep Research, Volume 35, Issue 5, October 2026.
ABSTRACT Central disorders of hypersomnolence are characterised by excessive daytime sleepiness. There has been growing interest in analysing sleep micro‐architecture, to further understand how sleep is affected by these conditions. We investigated if sleep spindle activity differed between children with narcolepsy, idiopathic hypersomnolence (IH) and ...
Marisha Shetty, Nushrika Kadam Kishore, Georgina Plunkett, Lauren C. Nisbet, Margot J. Davey, Gillian M. Nixon, Lisa M. Walter, Rosemary S. C. Horne   +7 more
wiley   +1 more source

Autopsy Confirmed Normal Pressure Hydrocephalus (NPH) Presenting With Corticobasal Syndrome

Clinical Case Reports, Volume 14, Issue 9, September 2026.
Brain MRI showing DESH, dorsal sulcal crowding, ventriculomegaly, and mild periventricular FLAIR white matter hyperintensities suggestive of trans ependymal edema. ABSTRACT Diagnostic large‐volume CSF drainage should be considered in patients with progressive cognitive/behavioral and motor symptoms localizing to frontal lobes in the presence of MRI ...
Manizhe Eslami Amirabadi, Shubir Dutt, Clair Yballa, Zachary A. Miller, Bruce L. Miller, Renaud La Joie, Salvatore Spina   +6 more
wiley   +1 more source

Early detection of Niemann-pick disease type C with cataplexy and orexin levels: continuous observation with and without Miglustat

Orphanet Journal of Rare Diseases, 2020
Study objectives Niemann-Pick type C (NPC) is an autosomal recessive and congenital neurological disorder characterized by the accumulation of cholesterol and glycosphingolipids.
A. Imanishi, T. Kawazoe, Y. Hamada, T. Kumagai, K. Tsutsui, N. Sakai, K. Eto, A. Noguchi, T. Shimizu, T. Takahashi, G. Han, K. Mishima, T. Kanbayashi, H. Kondo   +13 more
doaj   +1 more source

Relationships between pre‐, post‐, and inter‐ictal psychiatric symptoms in patients with epilepsy

Psychiatry and Clinical Neurosciences Reports, Volume 5, Issue 3, September 2026.
Abstract Aim Although pre‐ and post‐ictal psychiatric symptoms (PS) in patients with epilepsy are well known, the prevalences and pathophysiologies remain unclear. We investigated the prevalences and durations of pre‐ and post‐ictal PS, related factors, and associations between pre‐ and post‐ictal PS. Methods In the Neuropsychiatry Department of Kurume
Shingo Yasumoto, Hiromichi Motooka, Yuji Ito, Masaya Mashimoto, Kenta Murotani, Ryota Ogata, Motohiro Ozone   +6 more
wiley   +1 more source

Kleine-Levin syndrome and idiopathic hypersomnia: Spectrum disorders

Indian Journal of Psychological Medicine, 2011
Kleine-Levin syndrome (KLS) and idiopathic hypersomnia (IH) are primary sleep disorders of unknown etiologies, which often run a chronic course. The common core symptoms of these syndromes are hypersomnolence and sleep drunkenness, with periodic ...
Ravi Gupta, Vivekananda Lahan, Malini Srivastava   +2 more
doaj   +1 more source

Salivary biomarkers in sleep‐related disorders

Sleep Research, Volume 3, Issue 3, Page 272-285, September 2026.
Abstract The exploration of salivary biomarkers has emerged as a promising avenue in the diagnosis and management of sleep‐related disorders, such as obstructive sleep apnea (OSA), insomnia, and sleep deprivation. Saliva is a noninvasive biofluid that contains a wealth of biological markers, reflecting both local and systemic physiological changes ...
Chuan Xiang Li, Yi Wang, Ying Ni Lin, Jun Qi Lin, Ya Ru Yan, Xian wen Sun, Liu Zhang, Shi Qi Li, Ning Li, Qing Yun Li   +9 more
wiley   +1 more source

Cerebrospinal fluid orexin testing in Australians with narcolepsy type 1

Internal Medicine Journal, Volume 56, Issue 9, Page 1641-1643, September 2026.
Abstract A clinical diagnosis of narcolepsy type 1 can be challenging, particularly in relation to cataplexy. Despite its specificity, cerebrospinal fluid (CSF) orexin testing is under‐utilised in Australasia. We describe the use of CSF orexin testing in 15 clinically indicated patients from two sleep centres, highlighting its utility in the ...
Mario Fernando, Gianluca Cotta, Samantha Kung, Grace Garden, Jian Eu Tai, Elie Matar, Brendon Yee, Claire Ellender, Sheila Sivam   +8 more
wiley   +1 more source

iSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland

Journal of Sleep Research, Volume 35, Issue 4, August 2026.
Study overview and clustering results in the iSPHYNCS cohort. Participant demographics are summarized in a baseline table. Questionnaire data and metadata were processed through an unsupervised clustering pipeline. A Sankey plot illustrates individual assignment across clusters by diagnostic group.
Rafael Morand, Livia Fregolente, Julia van der Meer, Elena S. Wenz, Annina Helmy, Lorenzo Brigato, Jan D. Warncke, Kseniia Zub, Ramin Khatami, Zhongxing Zhang, Sigrid von Manitius, Silvia Miano, Jens Acker, Mathias Strub, Ulf Kallweit, Gert Jan Lammers, Athina Tzovara, Claudio L. A. Bassetti, Stavroula Mougiakakou, Markus H. Schmidt   +19 more
wiley   +1 more source