Results 11 to 20 of about 29,066 (192)

Proteogenomic Profiling of Idiopathic Pulmonary Arterial Hypertension Identifies Sex-Differential Proteins and Candidate Therapeutic Targets. [PDF]

Adv Sci (Weinh)
An integrated proteogenomic analysis of 44,137 predominantly European‐ancestry UK Biobank participants aged 40–69 years identifies 12 robust proteins associated with idiopathic pulmonary arterial hypertension. These proteins define a high‐mortality molecular endotype, support early detection and mortality prediction, reveal sex‐differential proteomic ...
Lin X, Zhang Y, Pu Y, Liu D, Lei T, Ma K, He Q, Dou Z, Liu Y, Liu D, He Y, Wang Y, Zheng X, Ma Y, Zhou J, Zhai W, Su B, Chen L, Li S.   +18 more
europepmc   +2 more sources

Idiopathic pulmonary arterial hypertension [PDF]

Disease Models & Mechanisms, 2010
Despite improved understanding of the pathobiology of pulmonary arterial hypertension (PAH), it remains a severe and progressive disease, usually culminating in right heart failure, significant morbidity and early mortality. Over the last decade, some major advances have led to substantial improvements in the management of PAH.
Amy L, Firth, Jess, Mandel, Jason X-J, Yuan   +2 more
  +6 more sources

Pulmonary Artery Aneurysm in Longstanding Idiopathic Pulmonary Arterial Hypertension. [PDF]

Dtsch Arztebl Int, 2023
Hinze CA, Park DH, Bollmann BA.
europepmc   +3 more sources

Outcomes in Children With Idiopathic Pulmonary Arterial Hypertension [PDF]

Circulation, 2004
Background— Treatment for idiopathic pulmonary arterial hypertension in children includes calcium channel blockade (CCB) for acute responders with vasodilator testing and chronic epoprostenol for nonresponders. We sought to determine parameters associated with survival and treatment success.
Delphine, Yung, Allison C, Widlitz, Erika Berman, Rosenzweig, Diane, Kerstein, Greg, Maislin, Robyn J, Barst   +5 more
openaire   +2 more sources

Scleroderma pulmonary arterial hypertension: the same as idiopathic pulmonary arterial hypertension? [PDF]

Curr Opin Pulm Med, 2023
Purpose of review Pulmonary arterial hypertension (PAH) is a common complication of systemic sclerosis (SSc), which confers significant morbidity and mortality. The current therapies and treatment strategies for SSc-associated PAH (SSc-PAH) are informed by those used to treat patients with idiopathic PAH (IPAH).
Khan SL, Mathai SC.
europepmc   +3 more sources

Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension

Pulmonary Circulation, 2020
We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach.
Gustavo A. Heresi, Jacob T. Mey, John R. Bartholomew, Ihab S. Haddadin, Adriano R. Tonelli, Raed A. Dweik, John P. Kirwan, Satish C. Kalhan   +7 more
doaj   +1 more source

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Severe thrombocytopenia in patients with idiopathic pulmonary arterial hypertension provided several strategies for lung transplantation

Pulmonary Circulation, 2020
While the prognosis of idiopathic pulmonary arterial hypertension has improved significantly due to newer medications, lung transplantation remains a critical therapeutic option for severe pulmonary arterial hypertension.
Takayuki Kobayashi, Ayako Shigeta, Jiro Terada, Nobuhiro Tanabe, Toshihiko Sugiura, Seiichiro Sakao, Kohei Taniguchi, Takahiro Oto, Koichiro Tatsumi   +8 more
doaj   +1 more source

Pulmonary arterial hypertension in pregnancy—a systematic review of outcomes in the modern era

Pulmonary Circulation, 2021
Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade.
Ting-Ting Low, Nita Guron, Robin Ducas, Kenichiro Yamamura, Pradeepkumar Charla, John Granton, Candice K Silversides   +6 more
doaj   +1 more source

Pulmonary venous remodeling in COPD‐pulmonary hypertension and idiopathic pulmonary arterial hypertension [PDF]

Pulmonary Circulation, 2017
Pulmonary vascular arterial remodeling is an integral and well‐understood component of pulmonary hypertension (PH). In contrast, morphological alterations of pulmonary veins in PH are scarcely described. Explanted lungs (n = 101) from transplant recipients with advanced chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary arterial ...
Andersen, Kasper Hasseriis, Andersen, Claus Bøgelund, Gustafsson, Finn, Carlsen, Jørn   +3 more
openaire   +3 more sources