Results 11 to 20 of about 47,637 (238)
Idiopathic pulmonary arterial hypertension [PDF]
Disease Models & Mechanisms, 2010 Despite improved understanding of the pathobiology of pulmonary arterial hypertension (PAH), it remains a severe and progressive disease, usually culminating in right heart failure, significant morbidity and early mortality. Over the last decade, some major advances have led to substantial improvements in the management of PAH.
Amy L, Firth +2 more
+6 more sources
Pulmonary Artery Aneurysm in Longstanding Idiopathic Pulmonary Arterial Hypertension. [PDF]
Dtsch Arztebl Int, 2023 Hinze CA, Park DH, Bollmann BA.
europepmc +3 more sources
Scleroderma pulmonary arterial hypertension: the same as idiopathic pulmonary arterial hypertension? [PDF]
Curr Opin Pulm Med, 2023 Purpose of review Pulmonary arterial hypertension (PAH) is a common complication of systemic sclerosis (SSc), which confers significant morbidity and mortality. The current therapies and treatment strategies for SSc-associated PAH (SSc-PAH) are informed by those used to treat patients with idiopathic PAH (IPAH).
Khan SL, Mathai SC.
europepmc +3 more sources
Hepatology, EarlyView., 2022 A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan +19 more
wiley +1 more source
Transcriptional profiling of lung cell populations in idiopathic pulmonary arterial hypertension
Pulmonary Circulation, 2020 Despite recent improvements in management of idiopathic pulmonary arterial hypertension, mortality remains high. Understanding the alterations in the transcriptome–phenotype of the key lung cells involved could provide insight into the drivers of ...
Didem Saygin +7 more
doaj +1 more source
Outcomes in Children With Idiopathic Pulmonary Arterial Hypertension [PDF]
Circulation, 2004 Background— Treatment for idiopathic pulmonary arterial hypertension in children includes calcium channel blockade (CCB) for acute responders with vasodilator testing and chronic epoprostenol for nonresponders. We sought to determine parameters associated with survival and treatment success.
Delphine, Yung +5 more
openaire +2 more sources
Plasma metabolomic profile in chronic thromboembolic pulmonary hypertension
Pulmonary Circulation, 2020 We aimed to characterize the plasma metabolome of chronic thromboembolic pulmonary hypertension patients using a high-throughput unbiased omics approach.
Gustavo A. Heresi +7 more
doaj +1 more source
Left main bronchus compression due to main pulmonary artery dilatation in pulmonary hypertension: two case reports [PDF]
, 2015 . Pulmonary arterial dilatation associated with pulmonary hypertension may result in significant compression of local structures. Left main coronary artery and left recurrent laryngeal nerve compression have been described.
Ariff, B +6 more
core +1 more source
Pulmonary Circulation, 2020 While the prognosis of idiopathic pulmonary arterial hypertension has improved significantly due to newer medications, lung transplantation remains a critical therapeutic option for severe pulmonary arterial hypertension.
Takayuki Kobayashi +8 more
doaj +1 more source
Pulmonary arterial hypertension in pregnancy—a systematic review of outcomes in the modern era
Pulmonary Circulation, 2021 Pregnancy is hazardous with pulmonary arterial hypertension, but maternal mortality may have fallen in recent years. We sought to systematically evaluate pulmonary arterial hypertension and pregnancy-related outcomes in the last decade.
Ting-Ting Low +6 more
doaj +1 more source