Results 61 to 70 of about 47,637 (238)

Pulmonary Artery Pulse Wave Velocity in Idiopathic Pulmonary Arterial Hypertension

Canadian Journal of Cardiology, 2013
Idiopathic pulmonary artery (PA) hypertension (IPAH) is associated with severe PA remodelling. Although the resulting increase in pulse wave velocity (PWV) might be of major pathophysiological relevance, little is known about PA-PWV in IPAH. The aim of this study was to characterize PA-PWV and its predictors in patients with IPAH.We studied 26 ...
Kopeć, Grzegorz, Moertl, Deddo, Jankowski, Piotr, Tyrka, Anna, Sobień, Bartosz, Podolec, Piotr   +5 more
openaire   +3 more sources

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

High geographic prevalence of pulmonary artery hypertension: associations with ethnicity, drug use, and altitude

Pulmonary Circulation, 2020
While estimates of pulmonary arterial hypertension incidence and prevalence commonly range from 1–3/million and 15–25/million, respectively, clinical experience at our institution suggested much higher rates.
Jason Dubroff, Lana Melendres, Yan Lin, Daniel Raley Beene, Loren Ketai   +4 more
doaj   +1 more source

Oestrogen receptor alpha in pulmonary hypertension [PDF]

, 2015
Aims Pulmonary arterial hypertension (PAH) occurs more frequently in women with mutations in bone morphogenetic protein receptor type 2 (BMPR2) and dysfunctional BMPR2 signalling underpinning heritable PAH.
Audrey F. Wright, Austin, Benza, Chambliss, Dempsie, Dempsie, Eddahibi, Huang, Humbert, Jala, Kawut, Keegan, Kirsty Mair, Lahm, Lindberg, Long, Long, Lynn Loughlin, Ma, Machado, MacLean, Mair, Margaret Nilsen, Margaret R. Maclean, Marie-Ann Ewart, Marino, Massaro, Massaro, Matori, Matsumoto, Mcgoon, Mendelsohn, Meyer, Meyer, Morani, Nadadur, Nilsson, Pattarozzi, Pedram, Pedram, Rajkumar, Roberts, Rubanyi, Ryu, Shapiro, Takahashi, Umar, Ventetuolo, White, White, White, Wu, Yang, Yvonne Dempsie   +53 more
core   +4 more sources

Respiratory Organ‐on‐a‐Chip for Disease Modeling: From Architecture to Functional Integration

Advanced Healthcare Materials, EarlyView.
Respiratory organ‐on‐a‐chip (ROC) models capture key mechanical and cellular cues of the human respiratory system, enabling quantitative dissection of disease mechanisms. This review links ROC architectures to disease modeling, functional integration, and commercialization, and proposes a decision framework that aligns model complexity with mechanistic
Jinzhuo Hu, Yongjie Tang, Sidi Liu, Tao Xu, Qian Liu   +4 more
wiley   +1 more source

A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism

Pulmonary Circulation, 2022
The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1‐pulmonary arterial hypertension (PAH) was examined.
Margaret R. MacLean, Divya Pandya, Emilia M. Swietlik, Nina Denver, Kirsty Mair, Nicholas W. Morrell, Stefan Gräf, National Cohort Study for Idiopathic and Heritable Pulmonary Arterial Hypertension Consortium   +7 more
doaj   +1 more source

Pulmonary artery dissection in long standing idiopathic pulmonary arterial hypertension: A case report

Radiology Case Reports, 2022
Pulmonary arterial dissection (PAD) is a rare and often lethal complication of chronic pulmonary arterial hypertension (PAH), which may occurs in patients with idiopathic pulmonary arterial hypertension (IPAH) and potentially in those with connective ...
Luis Regalado, BS, MSc, Carol Vitellas, BA, Lindsay Wright, MD, Asvin Ganapathi, MD, Bryan A. Whitson, MD, PhD, Chiemezie Chianotu Amadi, MD, MA   +5 more
doaj   +1 more source

Pulmonary Arteriopathy and Idiopathic Pulmonary Arterial Hypertension in Six Dogs [PDF]

Veterinary Pathology, 2006
Pulmonary arteriopathy (PA) is the pathologic hallmark in human medicine of diffuse constrictive (medial and intimal remodeling) or multifocal complex (plexiform and dilatative lesions) arterial lesions, or both, that lead to irreversible obliteration of the arterial lumen.
Zabka, T., Campbell, F. E., Wilson, D.
openaire   +4 more sources

DOT1L Drives Endothelial‐to‐Mesenchymal Transition and Fibrotic Vascular Remodeling via H3K79 Methylation

Advanced Science, EarlyView.
DOT1L as a central epigenetic regulator of EndoMT and pulmonary fibrosis. Acting as an early epigenetic switch, it translates TGFβ–SMAD signaling into H3K79me2‐mediated chromatin remodeling, selectively activates fibrosis‐related genes, and primes ECs for rapid mesenchymal transition.
Yaofeng Wang, Xing Peng, Jingjing Chen, Yun Zhang, Tinghong Zhang, Jingyuan Zhang, Jiaying Fan, Hui Zheng, Qiaoyuan Liu, Zhimin Song, Zhan‐Peng Huang, Shu Meng   +11 more
wiley   +1 more source

Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation

Respiratory Research, 2009
Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by structural alterations of microscopically small pulmonary arterioles.
Sakao Seiichiro, Tatsumi Koichiro, Voelkel Norbert F   +2 more
doaj   +1 more source