Results 151 to 160 of about 182,666 (399)

Specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT2BR) demonstrates antifibrotic effects in murine models and ex vivo models of scleroderma skin

open access: yesArthritis &Rheumatology, Accepted Article.
Objectives Systemic sclerosis (SSc) is a connective tissue disease with fibrotic remodeling of the skin and various internal organs. SSc is associated with the highest case‐specific mortality of all rheumatic autoimmune diseases with limited antifibrotic treatment options.
Thuong Trinh‐Minh   +12 more
wiley   +1 more source

‘Teach me how to look after myself’: What people with bronchiectasis want from education in a pulmonary rehabilitation setting

open access: yesThe Clinical Respiratory Journal, Volume 17, Issue 1, Page 59-69, January 2023., 2023
In the education component of pulmonary rehabilitation, people with bronchiectasis seek to obtain greater clarity on the underlying cause of their condition and its prognosis. Further knowledge about self‐management strategies, treatment for extra‐pulmonary symptoms and the role of exercise outside of pulmonary rehabilitation as part of management were
Annemarie L. Lee   +12 more
wiley   +1 more source

Consensus document for the diagnosis and treatment of idiopathic pulmonary fibrosis

open access: yesRevista Portuguesa de Pneumologia (English Edition), 2016
Idiopathic pulmonary fibrosis is a rare interstitial lung disease included in the Idiopathic Interstitial Pneumonias group. Although several potential risk factors have been described, it is a progressive fibrosing disease of unknown cause affecting ...
C. Robalo Cordeiro   +12 more
doaj  

Joint Models for Time-to-Event Data and Longitudinal Biomarkers of High Dimension [PDF]

open access: yesarXiv, 2016
Joint models for longitudinal biomarkers and time-to-event data are widely used in longitudinal studies. Many joint modeling approaches have been proposed to deal with different types of longitudinal biomarkers and survival outcomes. However, most existing joint modeling methods cannot deal with a large number of longitudinal biomarkers simultaneously,
arxiv  

Diffuse pulmonary hemosiderosis after exposure to pesticides - A case report [PDF]

open access: yes, 1998
This report describes the clinical, radiological, microscopical and ligandohistochemical findings in a 17-year-old woman who suffered from an acute onset of pulmonary hemosiderosis after inhalation of pesticides used for the cultivation of strawberries ...
Altiner, Mithat   +5 more
core   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

open access: yesBMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan   +12 more
wiley   +1 more source

99mTc-MIBI Lung Scintigraphy in the Assessment of Pulmonary Involvement in Interstitial Lung Disease and Its Comparison With Pulmonary Function Tests and High-Resolution Computed Tomography: A Preliminary Study [PDF]

open access: yes, 2015
The differentiation of active inflammatory processes from an inactive form of the disease is of great value in the management of interstitial lung disease (ILD).
Assadi, M.   +6 more
core   +2 more sources

The therapy of idiopathic pulmonary fibrosis: what is next?

open access: yesEuropean Respiratory Review, 2019
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrosing interstitial lung disease, characterised by progressive scarring of the lung and associated with a high burden of disease and early death.
V. Somogyi   +5 more
semanticscholar   +1 more source

Prevalence of Cystic Fibrosis Carrier Status in Chronic Rhinosinusitis Without Nasal Polyp

open access: yes
International Forum of Allergy &Rhinology, EarlyView.
Do‐Yeon Cho   +4 more
wiley   +1 more source

Lamellarin D Acts as an Inhibitor of Type I Collagen Production

open access: yesChemMedChem, EarlyView.
COL1A2 gene, encoding type I collagen, is a key target for pulmonary fibrosis. We established a screening system to identify small molecules that inhibit COL1A2 gene expression. Using this system, we screen a library of compounds and identify lamellarin D as a potent inhibitor of COL1A2 expression, suggesting lamellarin D is a promising new lung ...
Daisuke Okuno   +19 more
wiley   +1 more source

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