Results 241 to 250 of about 117,210 (347)

Predicting acute decompensated heart failure using circadian markers from heart rate time series

ESC Heart Failure, Volume 12, Issue 6, Page 4095-4107, December 2025.
Circadian metrics—amplitude, mesor, and acrophase—derived from a wrist‐worn heart rate monitor can predict acute decompensated heart failure (ADHF) up to 21 days before onset. In 65 post‐ADHF patients, an LSTM model achieved 74% sensitivity, and 73% specificity trained on 21‐day sequences. These findings support circadian rhythm analysis as a promising
Valerie A. A. van Es, Mayke M. C. J. van Leunen, Ignace L. J. de Lathauwer, Cindy C. A. G. Verstappen, René A. Tio, Ruud F. Spee, Lu Yuan, Monica Betta, Giacomo Handjaras, Hareld M. C. Kemps   +9 more
wiley   +1 more source

Four decades of heart–lung transplantation: Milestones and outcomes in advanced cardiorespiratory failure

ESC Heart Failure, Volume 12, Issue 6, Page 3899-3909, December 2025.
Abstract Aims Heart–lung transplantation (HLTx) remains a life‐saving intervention for patients with end‐stage cardiopulmonary failure. We retrospectively analysed long‐term HLTx outcomes at our centre to assess survival trends and evaluate the impact of evolving immunosuppressive, surgical and perioperative strategies.
L. Lily Rosenthal, Anna Maria Mühlbauer, Carola Grinninger, Nikolaus A. Haas, Heinrich Netz, Robert Dalla Pozza, Jürgen Hörer, Sebastian Michel, R. Schramm, D. Graetz, Christian Hagl   +10 more
wiley   +1 more source

Standard pulmonary function tests and respiratory oscillometry patterns in hypersensitivity pneumonitis and idiopathic pulmonary fibrosis. [PDF]

BMJ Open Respir Res
Wu JKY, Xu JJ, Numakura T, Ryan CM, McInnis MC, Binnie M, Shapera S, Fisher JH, Hantos Z, Chow CW.   +9 more
europepmc   +1 more source

Circulating oxylipins predict mortality in heart failure with preserved ejection fraction

ESC Heart Failure, Volume 12, Issue 6, Page 4255-4265, December 2025.
A targeted LC–MS lipidomics approach identified arterial 15‐keto PGF2a as associated with 5‐year mortality in 90 patients with HFpEF. Abstract Aims Heart failure with preserved ejection fraction (HFpEF) poses significant diagnostic, prognostic and therapeutic challenges, with high morbidity and mortality rates.
Vaishnavi Aradhyula, Sareeta Manandhar, Alborz Sherafati, Alex Kloster, Anas Fares, Prabhatchandra Dube, Pamela S. Brewster, George V. Moukarbel, Krishna Rao Maddipati, Steven T. Haller, David J. Kennedy, Rajesh Gupta, Samer J. Khouri   +12 more
wiley   +1 more source

How Adherence Shapes Persistence in Idiopathic Pulmonary Fibrosis Treatment: A Call for Real-World Insight. [PDF]

Ann Am Thorac Soc
Borrás-Blasco J, Valcuende-Rosique A, Cornejo-Uixeda S.   +2 more
europepmc   +1 more source

Role of NPPB for recovery post ventricular assist device in paediatric dilated cardiomyopathy: Single‐cell multiomics

ESC Heart Failure, Volume 12, Issue 6, Page 4463-4474, December 2025.
This study investigated factors associated with left ventricular recovery after LVAD implantation in paediatric dilated cardiomyopathy. Patients were classified into recovery and non‐recovery groups. Single‐nucleus sequencing revealed higher NPPB expression and altered apoptosis‐related pathways in the recovery group.
Yosuke Kugo, Takuji Kawamura, Akima Harada, Yuji Tominaga, Kenji Miki, Hidekazu Ishida, Takayoshi Ueno, Shigeru Miyagawa   +7 more
wiley   +1 more source

Cytokine Expression Profiling in Idiopathic Pulmonary Fibrosis: Insights From Integrative Proteomic Analysis. [PDF]

Can Respir J
Shen C, Wang W, Li G, Wei D, Yang X, Jiang C, Sheng Y, Chen Y, Xu J, Ye S, Chen J.   +10 more
europepmc   +1 more source

Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice

Exploration, Volume 5, Issue 6, December 2025.
1. Caffeic acid (CA) is a novel senomorphic. 2. Annexin A5 is the direct protein target of CA in senescent cells. 3. The covalent binding of CA to Annexin A5 protein triggers its degradation, PKCθ deactivation, and the inhibition of the NF‐κB inflammatory pathway. 4. CA effectively alleviates inflammation and lung fibrosis in mouse model.
Yinhua Zhu, Ying Zhang, Qianyu Zhang, Ping Song, Junzhe Zhang, Ang Ma, Chen Wang, Peng Gao, Tong Yang, Lirun Zhou, Qiaoli Shi, Yin Kwan Wong, Yongting Luo, Huan Tang, Jigang Wang   +14 more
wiley   +1 more source

Evaluation of large language model-generated medical information on idiopathic pulmonary fibrosis. [PDF]

Front Artif Intell
Cherrez-Ojeda I, Frye BC, Hoheisel A, Cortes-Telles A, Robles-Velasco K, Mateos-Toledo HN, Figueiredo RG, Ryerson CJ, Rodas-Valero G, Calderón JC.   +9 more
europepmc   +1 more source

The Human Respiratory Virome in Health and Disease: Interactions, Dysbiosis, and Methodological Challenges

Advanced Genetics, Volume 6, Issue 4, December 2025.
This article examines how the respiratory virome contributes to health and disease, highlighting its interactions with the host and bacteriome. Key disease associations and present knowledge gaps are outlined. The review discusses challenges in sample collection and preprocessing, and presents future research directions for understanding virome ...
Xiaoxuan Yao, Xiaohui Zou, Bin Cao
wiley   +1 more source