Results 191 to 200 of about 18,680 (231)

LRP6 aggravates proliferation, invasion, and immunosuppression in diffuse large B-cell lymphoma: a novel prognostic marker and therapy target. [PDF]

Ann Hematol
Li L, Yang J, Liu H, Yue L, Cao T, Zeng P.   +5 more
europepmc   +1 more source

20(S/R)-Ginsenoside Rh1 Alleviates AOM/DSS-Induced Colorectal Cancer: Gut-Microbiota Modulation and Tryptophan-Metabolism-Mediated AhR/PXR Activation and IDO1. [PDF]

Int J Mol Sci
Lu L, Min J, Gao Y, Yang G, Zhao Z, Kang Y, Zhao Y, Zhao L, Li S.   +8 more
europepmc   +1 more source

An adverse tumor-protective effect of IDO1 inhibition

Cell Reports Medicine, 2023
By restoring tryptophan, indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors aim to reactivate anti-tumor T cells. However, a phase III trial assessing their clinical benefit failed, prompting us to revisit the role of IDO1 in tumor cells under T cell attack.
Daniel Peeper
exaly   +5 more sources

IDO1 inhibitors block septic cytokine storm by suppressing the IDO1-AHR-CYP1A1 axis

Biomedicine and Pharmacotherapy
Indoleamine-2,3-dioxygenase 1 (IDO1) is the rate-limiting enzyme in tryptophan (Trp) catabolism along kynurenine (Kyn) pathway. Increased IDO1 activity has been noticed in patients with sepsis, while IDO1's involvement in sepsis, especially in the initial cytokine storm phase is not yet completely understood. Using the GEO database and clinical samples
Qing Yang, Zhen Ning Tony He, Zhiyao Li   +2 more
exaly   +3 more sources

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Effects of Ido1 on mouse decidualization

Molecular Biology, 2015
Indoleamine 2,3-dioxygenase 1 (Ido1) is a rate-limiting enzyme which converts the essential amino acid tryptophan to kynurenine. The aim of this study was to investigate the expression and regulation of Ido1 in mouse uterus during decidualization. The results showed that Ido1 mRNA expression gradually increased from day 1 to 4 of pregnancy and reached ...
D-D, Li, Y-H, Yin, J-Y, Wu, Z-Q, Yang, H, Cao, Q-L, Zhang, B, Guo, Z-P, Yue   +7 more
openaire   +2 more sources

Discovery of novel IDO1 inhibitors targeting the protein’s apo form through scaffold hopping from holo-IDO1 inhibitor

Bioorganic and Medicinal Chemistry Letters, 2021
Immunomodulating enzyme IDO1 plays an important role in tumor immune resistance. Inhibiting IDO1 by small molecules with new mechanism of action is a potential strategy in IDO1 inhibitor development. Based on our urea derived compound originally binding with holo-IDO1, through scaffold hopping, a series of diisobutylaminophenyl hydroxyamidine compounds
Yungen Xu, Yi Zou, Qihua Zhu
exaly   +3 more sources

A patent review of IDO1 inhibitors for cancer

Expert Opinion on Therapeutic Patents, 2018
Indoleamine 2,3-dioxygenase 1 (IDO1) is overexpressed by cancer cells and the antigen presenting dendritic cells in the tumor microenvironment (TME). Activation of IDO1 depletes tryptophan and produces kynurenine, which induces T cell anergy and suppresses tumor control by the immune system.
Jae Eun Cheong, Lijun Sun
exaly   +3 more sources