Results 1 to 10 of about 29,794,370 (246)

Indoleamine 2,3-Dioxygenase 1: A Promising Therapeutic Target in Malignant Tumor [PDF]

Frontiers in Immunology, 2021
Tumorigenesis is a complex multifactorial and multistep process in which tumors can utilize a diverse repertoire of immunosuppressive mechanisms to evade host immune attacks.
Xiaotian Song, Xiaotian Song, Qianqian Si, Qianqian Si, Rui Qi, Rui Qi, Weidan Liu, Miao Li, Miao Li, Mengyue Guo, Mengyue Guo, Lin Wei, Lin Wei, Zhiyan Yao, Zhiyan Yao   +14 more
doaj   +5 more sources

Indoleamine-2,3-Dioxygenase 1 Deficiency Suppresses Seizures in Epilepsy [PDF]

Frontiers in Cellular Neuroscience, 2021
Background: Indoleamine-2,3-dioxygenase 1 (IDO1) is the initial and rate-limiting enzyme in the metabolism of tryptophan (TRP) to kynurenine (KYN).
Ning Deng, Jiao Hu, Yu Hong, Yu Hong, Yuewen Ding, Yuewen Ding, Yifan Xiong, Zhiyong Wu, Zhiyong Wu, Wei Xie, Wei Xie   +10 more
doaj   +3 more sources

Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface [PDF]

International Journal of Tryptophan Research, 2020
Immunohistochemical localization of indoleamine 2,3-dioxygenase-1 and indoleamine 2,3-dioxygenase-2, the first and rate-limiting enzyme in tryptophan metabolism along the kynurenine pathway, has been studied in order to better understand the physiological significance of these enzymes at the maternal-fetal interface of human pregnancy with a ...
Yoshiki Kudo, Iemasa Koh, Jun Sugimoto   +2 more
exaly   +3 more sources

Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human monocytes [PDF]

iScience, 2023
Summary: Human extravillous trophoblast (EVT) invades the maternal endometrium and reconstructs uterine spiral arteries cooperatively with maternal immune cells. Although EVT has allogeneic paternal antigens, the maternal immune system does not reject it.
Takuma Suzuki, Takashi Iizuka, Kyosuke Kagami, Takeo Matsumoto, Rena Yamazaki, Takiko Daikoku, Akihito Horie, Masanori Ono, Akira Hattori, Hiroshi Fujiwara   +9 more
doaj   +2 more sources

Indoleamine 2,3-dioxygenase 1 regulates cell permissivity to astrovirus infection. [PDF]

Mucosal Immunol, 2023
Astroviruses cause a spectrum of diseases spanning asymptomatic infections to severe diarrhea, but little is understood about their pathogenesis. We previously determined that small intestinal goblet cells were the main cell type infected by murine astrovirus-1.
Cortez V, Livingston B, Sharp B, Hargest V, Papizan JB, Pedicino N, Lanning S, Jordan SV, Gulman J, Vogel P, DuBois RM, Crawford JC, Boyd DF, Pruett-Miller SM, Thomas PG, Schultz-Cherry S.   +15 more
europepmc   +5 more sources

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase. [PDF]

Int J Tryptophan Res, 2022
Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first and rate-limiting step of the Kyn pathway.
Yoshioka S, Ikeda T, Fukuchi S, Kawai Y, Ohta K, Murakami H, Ogo N, Muraoka D, Takikawa O, Asai A.   +9 more
europepmc   +3 more sources

The role of indoleamine 2,3-dioxygenase 1 in early-onset post-stroke depression [PDF]

Frontiers in Immunology, 2023
BackgroundThe immune-inflammatory response has been widely considered to be involved in the pathogenesis of post-stroke depression (PSD), but there is ambiguity about the mechanism underlying such association.MethodsAccording to Diagnostic and ...
Hengshu Chen, Xia Huang, Chang Zeng, Dongren Sun, Fan Liu, Jingyuan Zhang, Qiao Liao, Shihang Luo, Weiye Xu, Yeqing Xiao, Danfeng Zeng, Mingyu Song, Mingyu Song, Fafa Tian   +13 more
doaj   +2 more sources

Indoleamine 2,3-Dioxygenase 1 (IDO1) in Kidney Transplantation: A Guardian against Rejection. [PDF]

J Clin Med, 2023
Kidney transplantation is a crucial treatment for end-stage kidney disease, with immunosuppressive drugs helping to reduce acute rejection rates. However, kidney graft longevity remains a concern. This study explores the role of indoleamine 2,3-dioxygenase 1 (IDO1) in kidney transplant immunology.
Wiśnicki K, Donizy P, Hałoń A, Wawrzonkowski P, Janczak D, Krajewska M, Banasik M.   +6 more
europepmc   +3 more sources

Galectin-1 induces a tumor-associated macrophage phenotype and upregulates indoleamine 2,3-dioxygenase-1 [PDF]

iScience, 2023
Summary: Galectins are a group of carbohydrate-binding proteins with a presumed immunomodulatory role and an elusive function on antigen-presenting cells.
Asha M. Rudjord-Levann, Zilu Ye, Lise Hafkenscheid, Sabrina Horn, Renske Wiegertjes, Mathias A.I. Nielsen, Ming Song, Caroline B.K. Mathiesen, Jesse Stoop, Sean Stowell, Per Thor Straten, Hakon Leffler, Sergey Y. Vakhrushev, Sally Dabelsteen, Jesper V. Olsen, Hans H. Wandall   +15 more
doaj   +2 more sources

Indoleamine 2,3 dioxygenase 1 immobilization on magnetic nanoparticles for screening inhibitors from coffee [PDF]

Food Chemistry: X, 2023
In this study, a ligand fishing method was developed to screen potential indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors from coffee extracts by immobilization of IDO1 enzyme on amino-modified magnetic nanoparticles combined with UHPLC-Q-TOF-MS/MS ...
Zhuoting Liu, Yunfang Ping, Lumei Zhang, Jingran Zhang, Ann Van Schepdael, Xu Wang   +5 more
doaj   +2 more sources