Results 31 to 40 of about 29,794,370 (246)

Targeting Indoleamine 2,3-Dioxygenase 1: Fighting Cancers via Dormancy Regulation

Frontiers in Immunology, 2021
The connection between indoleamine 2,3-dioxygenase 1 (IDO1) and tumour dormancy – a quiescent state of tumour cells which has been consistently linked to metastasis and cancer recurrence – is rarely discussed despite the pivotal role of IDO1 in cancer ...
Chao Yang, Chan-Tat Ng, Chan-Tat Ng, Dan Li, Lei Zhang, Lei Zhang   +5 more
doaj   +1 more source

sj-docx-1-try-10.1177_11786469221138456 – Supplemental material for Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase

, 2022
Supplemental material, sj-docx-1-try-10.1177_11786469221138456 for Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase by Saeko Yoshioka, Tomonori Ikeda, Sogo Fukuchi, Yurika Kawai,
Osamu Takikawa (230148), Daisuke Muraoka (611837), Katsumi Ohta (14198608), Akira Asai (446940), Naohisa Ogo (446936), Saeko Yoshioka (14198596), Sogo Fukuchi (14198602), Tomonori Ikeda (14198599), Yurika Kawai (14198605), Hisashi Murakami (565962)   +9 more
core   +1 more source

Dexamethasone Induces the Expression and Function of Tryptophan-2-3-Dioxygenase in SK-MEL-28 Melanoma Cells

Pharmaceuticals, 2021
Tryptophan-2,3-dioxygenase (TDO) is one of the key tryptophan-catabolizing enzymes with immunoregulatory properties in cancer. Contrary to expectation, clinical trials showed that inhibitors of the ubiquitously expressed enzyme, indoleamine-2,3 ...
Marta Cecchi, Sara Paccosi, Angela Silvano, Ali Hussein Eid, Astrid Parenti   +4 more
doaj   +1 more source

Oligopeptide-mediated gene transfer into mouse corneal endothelial cells: Expression, design optimization, uptake mechanism and nuclear localization [PDF]

, 2009
Copyright © The Author 2009. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses?by-nc/2.0/uk/) which permits ...
Seow, WY, George, AJT, Yang, Y-Y
core   +1 more source

Tryptophan-degrading enzymes in tumoral immune resistance

Frontiers in Immunology, 2016
Tryptophan is required for T lymphocyte effector functions. Its degradation is one of the mechanisms selected by tumors to resist immune destruction.
Nicolas van Baren, Nicolas van Baren, Nicolas van Baren, Benoit J Van den Eynde, Benoit J Van den Eynde, Benoit J Van den Eynde   +5 more
doaj   +1 more source

Azole-Based Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitors

Journal of Medicinal Chemistry, 2021
The heme enzyme indoleamine 2,3-dioxygenase 1 (IDO1) plays an essential role in immunity, neuronal function, and aging through catalysis of the rate-limiting step in the kynurenine pathway of tryptophan metabolism. Many IDO1 inhibitors with different chemotypes have been developed, mainly targeted for use in anti-cancer immunotherapy. Lead optimization
Röhrig, Ute F, Majjigapu, Somi Reddy, Reynaud, Aline, Pojer, Florence, Dilek, Nahzli, Reichenbach, Patrick, Ascencao, Kelly, Irving, Melita, Coukos, George, Vogel, Pierre, Michielin, Olivier, Zoete, Vincent   +11 more
openaire   +6 more sources

Inhibitory effects of a selective prostaglandin E2 receptor antagonist RQ-15986 on inflammation-related colon tumorigenesis in APC-mutant rats.

PLoS ONE, 2021
Prostaglandin E2 receptor EP4 is involved in inflammation and related tumorigenesis in the colorectum. This study aimed to investigate the chemopreventive ability of RQ-15986, a selective EP4 antagonist, in colitis-related colorectal tumorigenesis.
Yohei Shirakami, Takayuki Nakanishi, Noritaka Ozawa, Takayasu Ideta, Takahiro Kochi, Masaya Kubota, Hiroyasu Sakai, Takashi Ibuka, Takuji Tanaka, Masahito Shimizu   +9 more
doaj   +1 more source

The role of placental tryptophan catabolism

Frontiers in Immunology, 2014
This review discusses the mechanisms and consequences of degradation of tryptophan (Trp) in the placenta, focussing mainly on the role of indoleamine 2,3-dioxygenase-1 (IDO1), one of three enzymes catalyzing the first step of the kynurenine pathway of ...
Peter eSedlmayr, Astrid eBlaschitz, Roland eStocker   +2 more
doaj   +1 more source

Systemic tryptophan homeostasis

Frontiers in Molecular Biosciences, 2022
Tryptophan is an essential amino acid, which is not only a building block for protein synthesis, but also a precursor for the biosynthesis of co-enzymes and neuromodulators, such as NAD/NADP(H), kynurenic acid, melatonin and serotonin.
Simon Klaessens, Simon Klaessens, Vincent Stroobant, Vincent Stroobant, Etienne De Plaen, Etienne De Plaen, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde, Benoit J. Van den Eynde   +9 more
doaj   +1 more source

N‑Benzyl/Aryl Substituted Tryptanthrin as Dual Inhibitors of Indoleamine 2,3-Dioxygenase and Tryptophan 2,3-Dioxygenase

, 2019
Indoleamine 2,3-dioxygenase 1 (IDO1), which catalyzes the initial and rate-limiting step of the kynurenine pathway of tryptophan catabolism, has emerged as a key target in cancer immunotherapy because of its role in enabling cancers to evade the immune ...
Shengnan Zhang (1340988), Xishuai Li (1884145), Nan Hu (4067), Shuangshuang Yang (1884151), Qing Yang (67856), Xin Fang (134979), Dan Yang (65758), Leilei Guo (6734231), Zhanling Guo (7460843), Jin Chao He (7460846), Chunxiang Kuang (1783678)   +10 more
core   +2 more sources