IDO1 (indoleamine 2,3-dioxygenase 1) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on IDO1 (indoleamine 2,3-dioxygenase 1), with data on DNA, on the protein encoded, and where the gene is implicated.
Chang, MY, Muller, AJ, Prendergast, GC
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Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase [PDF]
European Journal of Medicinal Chemistry, 2019 Tryptophan (Trp) catabolizing enzymes play an important and complex role in the development of cancer. Significant evidence implicates them in a range of inflammatory and immunosuppressive activities. Whereas inhibitors of indoleamine 2,3-dioxygenase-1 (IDO1) have been reported and analyzed in the clinic, fewer inhibitors have been described for ...
Maria Winters +10 more
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The first indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing carborane [PDF]
Dalton Trans., 2014 The first examples of indoleamine-2,3-dioxygenase-1 (IDO1) inhibitors containing a carborane cage are reported.
Austin, C. +9 more
core +6 more sources
Indoleamine 2,3-dioxygenase-expressing leukemic dendritic cells impair a leukemia-specific immune response by inducing potent T regulatory cells [PDF]
Haematologica, 2010 Background The immunoregulatory enzyme indoleamine 2,3-dioxygenase, which catalyzes the conversion of tryptophan into kynurenine, is expressed in a significant subset of patients with acute myeloid leukemia, resulting in the inhibition of T-cell ...
Antonio Curti +11 more
doaj +2 more sources
Structure-based optimization of type III indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors [PDF]
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 The haem enzyme indoleamine 2,3-dioxygenase 1 (IDO1) catalyses the rate-limiting step in the kynurenine pathway of tryptophan metabolism and plays an essential role in immunity, neuronal function, and ageing. Expression of IDO1 in cancer cells results in
Ute F. Röhrig +11 more
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Enhancement of radiation therapy by indoleamine 2,3 dioxygenase 1 inhibition through multimodal mechanisms [PDF]
BMC Cancer, 2023 Background Indoleamine 2,3-dioxygenase 1 (IDO1) is an enzyme that converts tryptophan to kynurenine. IDO1 expression is found not only in tumor cells but also in immune cells and is associated with tumor proliferation and immune responses.
Hiroaki Nozawa +9 more
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Indoleamine 2,3-dioxygenase 1 signaling orchestrates immune tolerance in Echinococcus multilocularis-infected mice [PDF]
Frontiers in Immunology, 2022 The cestode Echinococcus multilocularis larva infection causes lethal zoonotic alveolar echinococcosis (AE), a disease posing a great threat to the public health worldwide.
Ru Meng +7 more
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Immunoprognostic analysis of indoleamine 2,3-dioxygenase 1 in patients with cervical cancer. [PDF]
Medicine (Baltimore)The incidence of cervical cancer is increasing. Immunotherapies show better patient outcomes than monotherapies; however, the mainstay treatment for cervical cancer remains surgery and chemotherapy. Indoleamine 2,3-dioxygenase 1 (IDO1) acts on multiple tryptophan substrates, exhibiting antitumor, immunomodulatory, and antioxidant activities.
Xu C +5 more
europepmc +3 more sources
Positive allosteric modulation of indoleamine 2,3-dioxygenase 1 restrains neuroinflammation [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance Indoleamine 2,3-dioxygenase 1 (IDO1) is an immunoregulatory enzyme that transforms tryptophan into kynurenine, an endogenous agonist of the aryl hydrocarbon receptor (AhR) whose activation sustains IDO1 expression and activity over the long term in dendritic cells (DCs). Here we found that
Roberta Bianchi +2 more
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Indoleamine 2,3-dioxygenase 1 is essential for sustaining durable antibody responses. [PDF]
Immunity, 2021 Humoral immunity is essential for protection against pathogens, emphasized by the prevention of 2-3 million deaths worldwide annually by childhood immunizations. Long-term protective immunity is dependent on the continual production of neutralizing antibodies by the subset of long-lived plasma cells (LLPCs).
Lightman SM +8 more
europepmc +3 more sources