Results 41 to 50 of about 29,794,370 (246)

Targeting HSP90 sensitizes pancreas carcinoma to PD-1 blockade

OncoImmunology, 2022
Interferon gamma (IFNG/IFNγ)-induced adaptive immune resistance remains a challenge for tumor therapy. We observed that the chaperone heat shock protein 90 (HSP90) stabilizes the transcription factor signal transducer and activator of transcription 1 ...
Jiao Liu, Rui Kang, Guido Kroemer, Daolin Tang   +3 more
doaj   +1 more source

Recombinant human indoleamine 2,3-dioxygenase

, 2021
Indoleamine 2,3-dioxygenase (IDO) is a heme-containing dioxygenase that catalyses the first and rate-limiting step in the kynurenine (Kyn) pathway of L-tryptophan (L-Trp)catabolism.
Priambudi Kosim-Satyaputra (12307877)
core   +1 more source

Vitamin e-loaded membrane dialyzers reduce hemodialysis inflammaging

BMC Nephrology, 2019
Background Inflammaging is a persistent, low−grade, sterile, nonresolving inflammatory state, associated with the senescence of the immune system. Such condition downregulates both innate and adaptive immune responses during chronic disorders as type II ...
Vincenzo Sepe, Marilena Gregorini, Teresa Rampino, Pasquale Esposito, Rosanna Coppo, Francesco Galli, Carmelo Libetta   +6 more
doaj   +1 more source

IDO2 (indoleamine 2,3-dioxygenase 2) [PDF]

, 2010
Review on IDO2 (indoleamine 2,3-dioxygenase 2), with data on DNA, on the protein encoded, and where the gene is ...
Muller, AJ, MY Chang, Chang, MY, GC Prendergast, Metz, R, R Metz, AJ Muller, Prendergast, GC   +7 more
core   +1 more source

Evaluation of mode of indoleamine 2,3-dioxygenase 1 inhibition by 4,7-dichloroquinolines

European Journal of Medicinal Chemistry Reports, 2023
Herein, we report the development of synthetically simpler analogs of 4,7-dichloroquinoline (DCQ) as apo-indoleamine 2,3-dioxygenase 1(IDO1) protein targeting ligand to inhibit the activity of IDO1 enzyme.
Niku Moni Das, Biswa Mohan Prusty, Nirmalya Pradhan, Anjali Gupta, Miguel Carmena-Bargueño, Rama Karn, Horacio Pérez-Sánchez, Sachin Kumar, Debasis Manna   +8 more
doaj   +1 more source

Higher Circulating Kynurenine Levels Linked to Higher Risk of Sarcopenia in Older Adults: A Cohort Study and UK Biobank Analysis [PDF]

Endocrinology and Metabolism
Background While experimental studies show kynurenine, a tryptophan metabolite, drives muscle catabolism through pro-oxidative and inflammatory mechanisms, clinical evidence linking circulating kynurenine to sarcopenia in humans remains scarce.
June Yeon Kim, Yunju Jo, So Jeong Park, Ji Yeon Baek, Geonyoung Jang, Eunju Lee, Hyuk Sakong, Su Jung Kim, Sung-Jin Kim, Dongryeol Ryu, Hyun Ju Yoo, Beom-Jun Kim   +11 more
doaj   +1 more source

Advances in indoleamine 2,3-dioxygenase 1 medicinal chemistry

MedChemComm, 2017
Structure–function relationships of IDO1 and structure–activity relationships of inhibitors are discussed with an outlook on next generation IDO1 ligand.
Coletti, Alice, Greco, Francesco Antonio, Dolciami, Daniela, Camaioni, Emidio, Sardella, Roccaldo, Pallotta, Maria Teresa, Volpi, Claudia, Orabona, Ciriana, Grohmann, Ursula, Macchiarulo, Antonio   +9 more
openaire   +3 more sources

Review of 10 years of research on breast cancer patients: Focus on indoleamine 2,3-dioxygenase

, 2021
Therapeutic manipulation of the immune system in cancer has been an extensive area of research in the field of oncoimmunology. Immunosuppression regulates antitumour immune responses.
Farooq, Asim, Zulfiqar, Bilal, Loya, Asif, Asghar, Kashif   +3 more
core   +1 more source

Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors in clinical trials for cancer immunotherapy

Journal of Hematology & Oncology, 2021
Indoleamine 2,3-dioxygenase 1 (IDO1) is a heme enzyme that catalyzes the oxidation of L-tryptophan. Functionally, IDO1 has played a pivotal role in cancer immune escape via catalyzing the initial step of the kynurenine pathway, and overexpression of IDO1
Kai Tang, Ya-Hong Wu, Yihui Song, Bin Yu
doaj   +1 more source

Fused Heterocyclic Compounds as Potent Indoleamine-2,3-dioxygenase 1 Inhibitors [PDF]

ACS Medicinal Chemistry Letters, 2016
Uncontrolled metabolism of l-tryptophan (l-Trp) in the immune system has been recognized as a critical cellular process in immune tolerance. Indoleamine 2,3-dioxygenase 1 (IDO1) enzyme plays an important role in the metabolism of a local l-Trp through the kynurenine pathway in the immune systems. In this regard, IDO1 has emerged as a therapeutic target
Subhankar, Panda, Ashalata, Roy, Suman Jyoti, Deka, Vishal, Trivedi, Debasis, Manna   +4 more
openaire   +2 more sources